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  • Edoxaban, a direct oral factor Xa inhibitor, ameliorates coagulation, microvascular thrombus formation, and acute liver injury in a lipopolysaccharide-induced coagulopathy model in rats
    著者
    Morishima, Yoshiyuki., Shibutani, Tomoko., Noguchi, Kengo., Ito, Yusuke., Honda, Yuko.
    雑誌名
    J Thromb Thrombolysis
    52
    ページ
    9-17
    2021
    DOI
    10.1007/s11239-021-02381-y
    PMID
    33534029
    Online published
    2021 Feb 03
  • Discovery of a Novel Class of ERRα Agonists
    著者
    Shinozuka, Tsuyoshi., Ito, Shuichiro., Kimura, Takako., Izumi, Masanori., Wakabayashi, Kenji.
    雑誌名
    ACS Med Chem Lett
    12
    ページ
    817-821
    2021
    DOI
    10.1021/acsmedchemlett.1c00100
    PMID
    34055231
    Online published
    2021 Apr 21
  • Syntheses and antimicrobial activities of ogipeptin derivatives
    著者
    Takiguchi, Shingo., Homma, Hidehito., Fujisawa, Tetsunori., Hirota-Takahata, Yuki., Ono, Yasunori., Kizuka, Masaaki., Ishii, Yuki., Yoshimura, Satomichi., Nishi, Takahide.
    雑誌名
    Bioorg Med Chem Lett
    42
    ページ
    128093
    2021
    DOI
    10.1016/j.bmcl.2021.128093
    PMID
    33964447
    Online published
    2021 May 06
  • CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib
    著者
    Kagiyama, Yuki., Fujita, Shuhei., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Nakagawa, Makoto., Honma, Daisuke., Adachi, Nobuaki., Araki, Kazushi., Kato, Ayako., Inaki, Koichiro., Ono, Yoshimasa., Fukuhara, Suguru., Kobayashi, Yukio., Tobinai, Kensei., Kitabayashi, Issay.
    雑誌名
    Cancer Sci
    112
    ページ
    2314-2324
    2021
    DOI
    10.1111/cas.14905
    PMID
    33792119
    Online published
    2021 May 01
  • Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate
    著者
    Iida, Kenji., Ahmed, Amr H Abdelhamid., Nagatsuma, Akiko Kawano., Shibutani, Tomoko., Yasuda, Satoru., Kitamura, Michiko., Hattori, Chiharu., Abe, Manabu., Hasegawa, Jun., Iguchi, Takuma., Karibe, Tsuyoshi., Nakada, Takashi., Inaki, Koichiro., Kamei, Reiko., Abe, Yuki., Nomura, Taisei., Andersen, Jessica L., Santagata, Sandro., Hemming, Matthew L., George, Suzanne., Doi, Toshihiko., Ochiai, Atsushi., Demetri, George D., Agatsuma, Toshinori.
    雑誌名
    Cancer Discov
    11
    ページ
    1508-1523
    2021
    DOI
    10.1158/2159-8290.CD-20-1434
    PMID
    33579785
    Online published
    2021 Feb 12
  • Cryo-EM Structure of K +-Bound hERG Channel Complexed with the Blocker Astemizole
    著者
    Asai, Tatsuki., Adachi, Naruhiko., Moriya, Toshio., Oki, Hideyuki., Maru, Takamitsu., Kawasaki, Masato., Suzuki, Kano., Chen, Sisi., Ishii, Ryohei., Yonemori, Kazuko., Igaki, Shigeru., Yasuda, Satoshi., Ogasawara Satoshi., Senda. Toshiya., Murata, Takeshi.
    雑誌名
    Structure
    29
    ページ
    203-212
    2021
    DOI
    10.1016/j.str.2020.12.007
    PMID
    33450182
    Online published
    2021 Jan 14
  • Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions
    著者
    Suzuki, Kyosuke., Kawakami, Kohsaku., Fukiage, Masafumi., Oikawa, Michinori., Nishida, Yohei., Matsuda, Maki., Fujita, Takuya.
    雑誌名
    Pharmaceutics
    13
    ページ
    220
    2021
    DOI
    10.3390/pharmaceutics13020220
    PMID
    33562770
    Online published
    2021 Feb 05
  • Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
    著者
    Karlsson, Håkan K. R., Kasahara, Akiko., Ikeda, Mika., Chibalin, Alexander V., Harada, Jun., Rydén, Mikael., Krook, Anna., Kato, Mitsunori., Kubota, Kazuishi., Zierath, Juleen R.
    雑誌名
    Metabolism
    118
    ページ
    154726
    2021
    DOI
    10.1016/j.metabol.2021.154726
    PMID
    33581131
    Online published
    2021 Feb 11
  • Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease
    著者
    Katayama, Katsushi., Ishii, Ken., Terashima, Hideki., Tsuda, Eisuke., Suzuki, Makoto., Yotsumoto, Keiichi., Hiramoto, Kumiko., Yasumatsu, Isao., Torihata, Munefumi., Ishiyama, Takashi., Muto, Tsuyoshi., Katagiri, Takahiro.
    雑誌名
    ACS Med Chem Lett
    12
    ページ
    121-128
    2021
    DOI
    10.1021/acsmedchemlett.0c00572
    PMID
    Online published
    2020 Dec 28
  • Conformational plasticity of cyclic Ras-inhibitor peptides defines cell permeabilization activity
    著者
    Takeuchi, Koh., Misaki, Imai., Tokunaga, Yuji., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki ., Shimada, Ichio.
    雑誌名
    Angew Chem Int Ed Engl
    60
    ページ
    6567-6572
    2021
    DOI
    10.1002/anie.202016647
    PMID
    33427372
    Online published
    2021 Jan 11
  • Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation
    著者
    Nishimura, Masanori., Yamashita, Atsushi., Matsuura, Yunosuke., Okutsu, Junichi., Fukahori, Aiko., Hirata, Tsuyoshi., Nishizawa, Tomohiro., Ishii, Hirohito., Maekawa, Kazunari., Nakamura, Eriko., Kitamura, Kazuo., Nakamura, Kunihide., Asada, Yujiro.
    雑誌名
    J Atheroscler Thromb
    Online ahead of print
    ページ
    Online ahead of print
    2020
    DOI
    10.5551/jat.58248
    PMID
    33298635
    Online published
    2020 Dec 10
  • Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
    著者
    Guo, Chun-Jun., Chang, Fang-Yuan., Wyche, Thomas P., Backus, Keriann M., Acker, Timothy M., Funabashi, Masanori., Taketani, Mao., Donia, Mohamed S., Nayfach, Stephen., Pollard, Katherine S., Craik, Charles S., Cravatt, Benjamin F., Clardy, Jon., Voigt, Christopher A., Fischbach, Michael A.
    雑誌名
    Cell
    168
    ページ
    517-526
    2017
    DOI
    10.1016/j.cell.2016.12.021
    PMID
    28111075
    Online published
    2017 Jan 19
  • A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
    著者
    Nemet, Ina., Saha, Prasenjit Prasad., Gupta, Nilaksh., Zhu, Weifei., Romano, Kymberleigh A., Skye, Sarah M., Cajka, Tomas., Mohan, Maradumane L., Li, Lin., Wu, Yuping., Funabashi, Masanori., Ramer-Tait, Amanda E., Prasad, Sathyamangla Venkata Naga., Fiehn, Oliver., Rey, Federico E., Tang, W H Wilson., Fischbach, Michael A., DiDonato, Joseph A., Hazen, Stanley L.
    雑誌名
    Cell
    180
    ページ
    862-877
    2020
    DOI
    10.1016/j.cell.2020.02.016
    PMID
    32142679
    Online published
  • A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines
    著者
    Ogura, Yuji., Parsons, William H., Kamat, Siddhesh S., Cravatt, Benjamin F.
    雑誌名
    Nat Chem Biol
    12
    ページ
    669-671
    2016
    DOI
    10.1038/nchembio.2127
    PMID
    27399000
    Online published
    2016 Jul 11
  • Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV
    著者
    Reppas, Christos., Vrettos, Napoleon-Nikolaos., Dressman, Jennifer., Andreas, Cord J., Miyaji, Yoshihiro., Brown, Jonathan., Etherson, Kelly., Hanley, Sarah., Karkossa, Frank., Karlsson, Eva., Klein, Sandra., Maier, Gerd-Michael., McAllister, Mark., Mistry, Nena., Rosenblatt, Karin., Schäfer, Kerstin Julia., Smith, Kieran Lewis., Tomaszewska, Irena., Williams, James., Winge, Fredrik., Vertzoni Maria.
    雑誌名
    Eur J Pharm Biopharm "
    156
    ページ
    40-49
    2020
    DOI
    10.1016/j.ejpb.2020.08.025
    PMID
    32882421
    Online published
    2020 Aug 31
  • Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models
    著者
    Sasaki, Masato., Delawary, Mina., Sakurai, Hidetaka., Kobayashi, Hideki., Nakao, Naoki., Tsuru, Hiromi., Fukushima, Yumiko., Honzumi, Shoko., Moriyama, Sachiko., Wada, Naoya., Kaneko, Toshio., Yamada, Keisuke., Terasaka, Naoki., Kubota, Kazuishi.
    雑誌名
    Arteriosclerosis, Thrombosis, and Vascular Biology
    41
    ページ
    360-376
    2021
    DOI
    10.1161/ATVBAHA.120.314516
    PMID
    33086872
    Online published
    2020 Oct 22
  • Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
    著者
    Mizukoshi, Yumiko., Takeuchi, Koh., Tokunaga, Yuji., Matsuo, Hitomi., Imai, Misaki., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki., Shimada, Ichio.
    雑誌名
    Sci. Adv.
    6
    ページ
    eabd0480
    2020
    DOI
    10.1126/sciadv.abd0480
    PMID
    32998885
    Online published
    2020 Sep 30
  • Plasma Lipid Profiling of Three Types of Drug-Induced Liver Injury in Japanese Patients: A Preliminary Study
    著者
    Saito, Kosuke ., Kagawa, Tatehiro., Tsuji, Keiji., Kumagai, Yuji., Sato, Ken., Sakisaka, Shotaro., Sakamoto, Naoya., Aiso, Mitsuhiko., Hirose, Shunji., Mori, Nami., Tanaka, Rieko., Uraoka, Toshio., Takata, Kazuhide., Ogawa, Koji., Mori, Kazuhiko., Sato, Motonobu., Nishiya, Takayoshi., Takamatsu, Kazuhiko., Arakawa, Noriaki., Izumi, Takashi., Ohno, Yasuo., Saito, Yoshiro., Takikawa, Hajime.
    雑誌名
    Metabolites
    10
    ページ
    E355
    2020
    DOI
    10.3390/metabo10090355
    PMID
    32878279
    Online published
    2020 Aug 31
  • Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines
    著者
    Katayama, Katsushi., Ishii, Ken., Tsuda, Eisuke., Yotsumoto, Keiichi., Hiramoto, Kumiko., Suzuki, Makoto., Yasumatsu, Isao., Igarashi, Wataru., Torihata, Munefumi., Ishiyama, Takashi., Katagiri, Takahiro.
    雑誌名
    Bioorg Med Chem Lett
    30
    ページ
    127475
    2020
    DOI
    10.1016/j.bmcl.2020.127475.
    PMID
    32781218
    Online published
    2020 Aug 20
  • Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells
    著者
    Noguchi, Shingo., Ishikawa, Hirokazu., Wakita, Kenichi., Matsuda, Fumio., Shimizu, Hiroshi.
    雑誌名
    Scientific Reports
    10
    ページ
    13065
    2020
    DOI
    10.1038/s41598-020-70000-6
    PMID
    32747645
    Online published
    2020 Aug 03
  • Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine
    著者
    Tomono, Takumi., Yagi, Haruya., Ukawa, Masami., Ishizaki, Seiya., Miwa, Takahiro., Nonomura, Mao., Igi, Ryoji., Kumagai, Hironori., Miyata, Kohei., Tobita, Etsuo., Kobayashi, Hideo., Sakuma, Shinji.
    雑誌名
    Eur J Pharm Biopharm
    154
    ページ
    186-194
    2020
    DOI
    10.1016/j.ejpb.2020.07.003
    PMID
    32681963
    Online published
    2020 Jul 15
  • Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation
    著者
    Aki, Anri., Tanaka, Kento., Nagaoka, Nobumi., Kimura, Takako., Baba, Daichi., Onodera, Yoshikuni., Wada, Teiji., Maeda, Hiroaki., Nakanishi, Toshiyuki., Agatsuma, Toshinori., Komai, Tomoaki.
    雑誌名
    FASEB Bioadv
    2
    ページ
    478–488
    2020
    DOI
    10.1096/fba.2020-00008
    PMID
    32821879
    Online published
    2020 Jul 08
  • U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
    著者
    Papadopoulos, Kyriakos P., Borazanci, Erkut., Shaw, Alice T., Katayama, Ryohei., Shimizu, Yuki., Zhu, Viola W., Sun, Thomas Yang., Wakelee, Heather A., Madison, Russell., Schrock, Alexa B., Senaldi, Giorgio., Nakao, Naoki., Hanzawa, Hiroyuki., Tachibana, Masaya., Isoyama, Takeshi., Nakamaru, Kenji., Deng, Chenhui., Li, Meijing., Fan, Frank., Zhao, Qinying., Gao, Yanfei., Seto , Takashi., Jänne, Pasi A., Ou, Sai-Hong Ignatius.
    雑誌名
    Clin Cancer Res
    26
    ページ
    4785-4794
    2020
    DOI
    10.1158/1078-0432.CCR-20-1630
    PMID
    Online published
    2020 Jun 26
  • Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment
    著者
    Brinkwirth, Nina., Takasuna, Kiyoshi., Doi, Masafumi., Becker, Nadine., Obergrussberger, Alison., Friis, Søren., Furukawa, Hatsue., Hasegawa, Yuka., Oka, Takayuki., Ohtsuki, Atsushi., Fertig, Niels., Stoelzle-Feix, Sonja.
    雑誌名
    J Pharmacol Toxicol Methods
    105
    ページ
    106884
    2020
    DOI
    10.1016/j.vascn.2020.106884
    PMID
    32565325
    Online published
    2020 Jun 18
  • The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina
    著者
    Sayama, Ayako., Okado, Keiko., Yamaguchi, Mayu., Samata, Naozumi., Imaoka, Masako., Kai, Kiyonori., Mori, Kazuhiko.
    雑誌名
    Toxicol Pathol
    48
    ページ
    669-676
    2020
    DOI
    10.1177/0192623320931415
    PMID
    32538308
    Online published
    2020 Jun 15
  • A Metabolic Pathway for Bile Acid Dehydroxylation by the Gut Microbiome
    著者
    Funabashi, Masanori., Grove, Tyler L., Wang, Min., Varma, Yug., McFadden, Molly E., Brown, Laura C., Guo, Chunjun., Higginbottom, Steven., Almo, Steven C., Fischbach, Michael A.
    雑誌名
    Nature
    582
    ページ
    566-570
    2020
    DOI
    10.1038/s41586-020-2396-4
    PMID
    32555455
    Online published
    2020 Jun 17
  • Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor
    著者
    Shinozuka, Tsuyoshi., Kobayashi, Hiroyuki., Suzuki, Sayaka., Tanaka, Kyosuke., Karanjule, Narayan., Hayashi, Noriyuki., Tsuda, Toshifumi., Tokumaru, Eri., Inoue, Masahiro., Ueda, Kiyono., Kimoto, Hiroko., Domon, Yuki., Takahashi, Sakiko., Kubota, Kazufumi., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Sakakura, Tomoko., Takasuna, Kiyoshi., Abe, Yasuyuki., Watanabe, Toshiyuki., Kitano, Yutaka.
    雑誌名
    J Med Chem
    63
    ページ
    10204-10220
    2020
    DOI
    10.1021/acs.jmedchem.0c00259
    PMID
    32392056
    Online published
    2020 May 26
  • Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin With a Potential Implication of ECG Abnormalities of DMD Patients
    著者
    Rani, Abdul Qawee Mahyoob., Yamamoto, Tetsushi., Kawaguchi, Tatsuya., Maeta, Kazuhiro., Awano, Hiroyuki., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Int J Mol Sci
    21
    ページ
    3555
    2020
    DOI
    10.3390/ijms21103555
    PMID
    32443516
    Online published
    2020 May 18
  • Revisiting Biomolecular NMR Spectroscopy for Promoting Small-Molecule Drug Discovery
    著者
    Hanzawa, Hiroyuki., Shimada, Takashi., Takahashi, Mizuki., Takahashi, Hideo.
    雑誌名
    J Biomol NMR
    74
    ページ
    501-508
    2020
    DOI
    10.1007/s10858-020-00314-0
    PMID
    32306215
    Online published
    2020 Apr 18
  • Meta-analyses on Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Triple-Negative Breast Cancer
    著者
    Hirai, Takehiro., Nemoto, Asuka., Ito, Yoshinor., Matsuura, Masaaki.
    雑誌名
    Breast Cancer Res Treat
    181
    ページ
    189-198
    2020
    DOI
    10.1007/s10549-020-05615-4
    PMID
    32246379
    Online published
    2020 Apr 03
  • Discovery of Novel Pyrrole Derivatives as Potent Agonists for the Niacin Receptor GPR109A
    著者
    Miyazawa, Yuriko., Yamaguchi, Takahiro., Yamaguchi, Mitsuhiro., Tago, Keiko., Tamura, Akihiro., Sugiyama, Daisuke., Aburatani, Takahide., Nishizawa, Tomohiro., Kurikawa, Nobuya., Kono, Keita.
    雑誌名
    Bioorg Med Chem Lett
    30
    ページ
    127105
    2020
    DOI
    10.1016/j.bmcl.2020.127105
    PMID
    32199732
    Online published
    2020 Mar 10
  • Crystal Structure of the Mineralocorticoid Receptor Ligand-Binding Domain in Complex With a Potent and Selective Nonsteroidal Blocker, Esaxerenone (CS-3150)
    著者
    Takahashi, Mizuki., Ubukata, Osamu., Homma, Tsuyoshi., Asoh, Yusuke., Honzumi Masatoshi., Hayashi, Noriyuki., Saito, Keiji., Tsuruoka, Hiroyuki., Aoki, Kazumasa., Hanzawa, Hiroyuki.
    雑誌名
    FEBS Lett
    594
    ページ
    1615-1623
    2020
    DOI
    10.1002/1873-3468.13746
    PMID
    31991486
    Online published
    2020 Feb 19
  • The Urotensin II Receptor Antagonist DS37001789 Ameliorates Mortality in Pressure-Overload Mice With Heart Failure
    著者
    Nishi, Mina., Tagawa, Hideki., Ueno, Masumi., Marumoto, Shinji., Nagayama, Takahiro.
    雑誌名
    Heliyon
    6
    ページ
    e03352
    2020
    DOI
    10.1016/j.heliyon.2020.e03352
    PMID
    32055741
    Online published
    2020 Feb 03
  • Discovery of a Novel Class of State-Dependent Na V 1.7 Inhibitors for the Treatment of Neuropathic Pain
    著者
    Tanaka, Kyosuke., Kobayashi, Hiroyuki., Suzuki, Sayaka., Shibuya, Satoshi., Kimoto, Hiroko., Domon, Yuki., Kubota, Kazufumi., Kitano, Yutaka., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Shinozuka Tsuyoshi.
    雑誌名
    Chem Pharm Bull (Tokyo)
    68
    ページ
    653-663
    2020
    DOI
    10.1248/cpb.c20-00126
    PMID
    32612000
    Online published
  • An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics
    著者
    Hansmann, Simone., Miyaji, Yoshihiro., Dressman, Jennifer.
    雑誌名
    Eur J Pharm Biopharm
    122
    ページ
    186-196
    2018
    DOI
    10.1016/j.ejpb.2017.10.019
    PMID
    29111469
    Online published
    2017 Oct 27
  • Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions
    著者
    Kawakami, Kohsaku., Suzuki, Kyosuke., Fukiage, Masafumi., Matsuda, Maki., Nishida, Yohei., Oikawa, Michinori., Fujita, Takuya.
    雑誌名
    Journal of Drug Delivery Science and Technology
    56
    ページ
    101172
    2020
    DOI
    10.1016/j.jddst.2019.101172
    PMID
    Online published
    2019 Jul 22
  • Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
    著者
    Ohura, Kayoko., Igawa, Yoshiyuki., Tanaka, Maori., Matsumoto, Kana., Kasahara, Akiko., Wada, Naoya., Kubota, Kazuishi., Uno, Yasuhiro., Imai, Teruko.
    雑誌名
    Drug metabolism and disposition: the biological fate of chemicals
    48
    ページ
    146-152
    2020
    DOI
    10.1124/dmd.119.089011
    PMID
    31836607
    Online published
    2020 Jan 30
  • Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
    著者
    Kaji, Tomohiro., Koga, Hiroshi., Kuroha, Mutsumi., Akimoto, Toshihiko., Hayata, Kenji.
    雑誌名
    Scientific Reports
    10
    ページ
    3088
    2020
    DOI
    10.1038/s41598-020-59966-5
    PMID
    32080280
    Online published
    2020 Feb 20
  • A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model
    著者
    Machida, Yukino., Nakagawa, Makoto., Matsunaga, Hironori., Yamaguchi, Masayuki., Ogawara, Yoko., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Hattori, Ayuna., Itoh, Masao., Seki, Takahiko., Nishiya, Yumi., Nakamura, Koichi., Suzuki, Kanae., Imaoka, Tomoki., Baba, Daichi., Suzuki, Makoto., Sampetrean, Oltea., Saya, Hideyuki., Ichimura, Koichi., Kitabayashi, Issay.
    雑誌名
    Molecular cancer therapeutics
    19
    ページ
    375-383
    2020
    DOI
    10.1158/1535-7163.MCT-18-1349
    PMID
    31727689
    Online published
    2019 Nov 14
  • Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers
    著者
    Duisters, Kevin., Ogino, Shinji., Andou, Tomohiro., Ito, Kazumi., Akabane, Takafumi., Harms, Amy., Moerland, Matthijs., Hashimoto, Yuka., Ando, Ayumi., Ohtsu, Yoshiaki., Wada, Naoya., Yukinaga, Hideo., Meulman, Jacqueline., Kobayashi, Hiroyuki., Kobayashi, Nobuhiro., Suzumura, Kenichi., Hankemeier, Thomas.
    雑誌名
    Clinical pharmacology and therapeutics
    107
    ページ
    397-405
    2020
    DOI
    10.1002/cpt.1606
    PMID
    31400148
    Online published
    2019 Aug 10
  • Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition
    著者
    Nishiya, Yumi., Suzuki, Eiko., Ishizuka, Tomoko., Kazui, Miho., Sakurai, Hidetaka., Nakai, Daisuke.
    雑誌名
    Drug metabolism and pharmacokinetics
    35
    ページ
    45-55
    2020
    DOI
    10.1016/j.dmpk.2019.11.001
    PMID
    31926835
    Online published
    2019 Dec 24
  • Preclinical Development of U3-1784, a Novel FGFR4 Antibody against Cancer, and Avoidance of Its On-target Toxicity
    著者
    Bartz, Rene., Fukuchi, Keisuke., Ohtsuka, Toshiaki., Lange, Tanja., Gruner, Katrin., Watanabe, Ichiro., Hayashi, Shinko., Oda, Yoko., Kawaida, Reimi., Komori, Hironobu., Kashimoto, Yoshinori., Wirtz, Peter., Mayer, Jan Peter A.., Redondo-Muller, Mauricio., Saito, Shuntaro., Takahashi, Mizuki., Hanzawa, Hiroyuki., Imai, Emi., Martinez, Alberto., Hanai, Masaharu., Haussinger, Dieter., Chapman, Roger W.., Agatsuma, Toshinori., Bange, Johannes., Abraham, Reimar.
    雑誌名
    Molecular Cancer Therapeutics
    18
    ページ
    1832-1843
    2019
    DOI
    10.1158/1535-7163.MCT-18-0048
    PMID
    Online published
    2019 Jul 26
  • Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
    著者
    Kawai, Junya., Toki, Tadashi., Ota, Masahiro., Inoue, Hidekazu., Takata, Yoshimi., Asahi, Takashi., Suzuki, Makoto., Shimada, Takashi., Ono, Kaori., Suzuki, Kanae., Takaishi, Sachiko., Ohki, Hitoshi., Matsui, Satoshi., Tsutsumi, Shinji., Hirota, Yasuhide., Nakayama, Kiyoshi.
    雑誌名
    Journal of medicinal chemistry
    62
    ページ
    10204-10220
    2019
    DOI
    10.1021/acs.jmedchem.9b01113
    PMID
    31638799
    Online published
    2019 Oct 22
  • Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold
    著者
    Kawai, Junya., Ota, Masahiro., Ohki, Hitoshi., Toki, Tadashi., Suzuki, Makoto., Shimada, Takashi., Matsui, Satoshi., Inoue, Hidekazu., Sugihara, Chika., Matsuhashi, Norikazu., Matsui, Yumi., Takaishi, Sachiko., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    893-898
    2019
    DOI
    10.1021/acsmedchemlett.9b00069
    PMID
    Online published
    2019 May 24
  • Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity
    著者
    Taniguchi, Toru., Inagaki, Hiroaki., Baba, Daichi., Yasumatsu, Isao., Toyota, Akiko., Kaneta, Yasuyuki., Kiga, Masaki., Iimura, Shin., Odagiri, Takashi., Shibata, Yoshihiro., Ueda, Kiyono., Seo, Maki., Shimizu, Hiroki., Imaoka, Tomoki., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    737-742
    2019
    DOI
    10.1177/0192623318809062
    PMID
    Online published
    2019 Mar 15
  • Functional and Morphological Characteristics of Pancreatic Islet Lesions Induced by Quinolone Antimicrobial Agent Gatifloxacin in Rats
    著者
    Yabe, Koichi., Yamamoto, Yuka., Suzuki, Takami., Takada, Sanae., Mori, Kazuhiko.
    雑誌名
    Toxicologic pathology
    47
    ページ
    35-43
    2019
    DOI
    10.1177/0192623318809062
    PMID
    30407147
    Online published
    2018 Nov 08
  • Practical one-step glucuronidation via biotransformation
    著者
    Ohnuki, Takashi., Ejiri, Masahiko., Kizuka, Masaaki., Fujiwara, Mie., Nishi, Takahide.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    29
    ページ
    199-203
    2019
    DOI
    2019
    PMID
    Online published
    2018 Nov 28
  • Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones
    著者
    Komoriya, Satoshi., Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Miyauchi, Rie., Yoshida, Ken-Ichi., Kitamura, Takahiro., Takahashi, Hisashi.
    雑誌名
    Chemical & pharmaceutical bulletin
    67
    ページ
    47-58
    2019
    DOI
    10.1248/cpb.c18-00671
    PMID
    30606950
    Online published
    2019 Jan 01
  • Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma
    著者
    Nakagawa, Makoto., Fujita, Shuhei., Katsumoto, Takuo., Yamagata, Kazutsune., Ogawara, Yoko., Hattori, Ayuna., Kagiyama, Yuki., Honma, Daisuke., Araki, Kazushi., Inoue, Tatsuya., Kato, Ayako., Inaki, Koichiro., Wada, Chisa., Ono, Yoshimasa., Yamamoto, Masahide., Miura, Osamu., Nakashima, Yasuharu., Kitabayashi, Issay.
    雑誌名
    Cancer Science
    110
    ページ
    194-208
    2019
    DOI
    10.1111/cas.13840
    PMID
    30343511
    Online published
    2018 Nov 16
  • Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches
    著者
    Kubota, Kazuishi., Funabashi, Masanori., Ogura, Yuji.
    雑誌名
    Biochimica et Biophysica Acta - Proteins and Proteomics
    1867
    ページ
    22-27
    2019
    DOI
    10.1016/j.bbapap.2018.08.002
    PMID
    30392561
    Online published