-
HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non-Small Cell Lung Cancer
- 著者
- Yonesaka, Kimio., Tanizaki, Junko., Maenishi, Osamu., Haratani, Koji., Kawakami, Hisato., Tanaka, Kaoru., Hayashi, Hidetoshi., Sakai, Kazuko., Chiba, Yasutaka., Tsuya, Asuka., Goto, Hiroki., Otsuka, Eri., Okida, Hiroaki., Kobayashi, Maki., Yoshimoto, Ryoto., Funabashi, Masanori., Hashimoto, Yuuri., Hirotani, Kenji., Kagari, Takashi., Nishio, Kazuto., Nakagawa, Kazuhiko.
- 雑誌名
- Clin Cancer Res .
- 巻
- Online ahead of print.
- ページ
- Online ahead of print.
- 年
- 2021
- DOI
- 10.1158/1078-0432.CCR-21-3359
- PMID
- 34921025
- Online published
- 2021 Dec 17
-
Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains
- 著者
- Hamasuna, Ryoichi., Hanzawa, Hiroyuki., Moritomo, Ayako., Matsumoto, Masahiro., Aono, Hisami., Tomisaki, Ikko., Akasaka, Takaaki., Fujimoto, Naohiro., SkovJensen, Jørgen.
- 雑誌名
- J Infect Chemother
- 巻
- Online ahead of print.(S1341-321X(21)00322-6)
- ページ
- Online ahead of print.
- 年
- 2021
- DOI
- 10.1016/j.jiac.2021.11.011
- PMID
- 34836778
- Online published
- 2021 Nov 24
-
Highly sensitive in vitro cytokine release assay incorporating high-density preculture
- 著者
- Ito, Shiho., Miwa, Kyoko., Hattori, Chiharu., Aida, Tetsuo., Tsuchiya, Yoshimi., Mori, Kazuhiko.
- 雑誌名
- J Immunotoxicol
- DOI
- 10.1080/1547691X.2021.1984617
- PMID
- 34644231
- Online published
- 2021 Oct 13
-
Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
- 著者
- Okajima, Daisuke.,Yasuda, Satoru., Maejima, Takanori., Karibe, Tsuyoshi., Sakurai, Ken., Aida, Tetsuo., Toki, Tadashi., Yamaguchi, Junko., Kitamura, Michiko., Kamei, Reiko., Fujitani, Tomomichi., Honda, Tomoyo., Shibutani, Tomoko., Muramatsu, Sumie., Nakada, Takashi., Goto, Riki., Takahashi, Shu., Yamaguchi, Miki., Hamada, Hirofumi., Noguchi, Yutaka., Murakami, Masato., Abe, Yuki., Agatsuma, Toshinori.
- 雑誌名
- Mol Cancer Ther
- 巻
- 20
- ページ
- 2329-2340
- 年
- 2021
- DOI
- 10.1158/1535-7163.MCT-21-0206
- PMID
- 34413126
- Online published
- 2021 Aug 19
-
Expanded precision medicine capabilities for strengthening oncology drug development at Daiichi Sankyo
- 著者
- Murakami, Masato., Tokui, Taro., Nakamaru, Kenji., Cogswell, John., Ford, Shirin Khambata., Gallant, Gilles.
- 雑誌名
- Journal of Precision Medicine
- DOI
- https://www.thejournalofprecisionmedicine.com/wp-content/uploads/expanded-precision.pdf
- PMID
- Online published
-
4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors
- 著者
- Kanada, Ryutaro., Suzuki, Takashi., Murata, Takeshi., Miyazaki, Masaki., Shimada, Takashi., Kuroha, Mutsumi., Minami, Megumi., Higuchi, Saito., Tominaga, Yuichi., Naito, Hiroyuki.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2021.128358
- PMID
- 34534674
- Online published
- 2021 Sep 14
-
New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)
- 著者
- Masada,Takato., Takagi, Toshihide., Minami, Keiko., Kataoka, Makoto., Takeyama, Shoko., Fujii, Yoshimine., Takahashi, Masayuki., Yamashita, Shinji.
- 雑誌名
- Journal of Drug Delivery Science and Technology
- DOI
- 10.1016/j.jddst.2021.102747
- PMID
- Online published
- 2021 Jul 24
-
Reforms of regulatory pathways for approval of new antineoplastic drugs in Japan from 2004 to 2019 and accompanying changes in pivotal clinical trial designs
- 著者
- Hirai, Takehiro., Suzuki, Asuka., Yamori, Takao., Matsuura, Masaaki.
- 雑誌名
- Invest New Drugs
- 巻
- Online ahead of print
- ページ
- Online ahead of print
- 年
- 2021
- DOI
- 10.1007/s10637-021-01165-8
- PMID
- 34417913
- Online published
- 2021 Aug 21
-
A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
- 著者
- Furuzono, Shinji., Kubota,Tetsuya., Taura, Junki., Konishi, Masahiro.,
Naito, Asuka., Tsutsui, Masato., Karasawa, Hiroshi., Kubota, Naoto., Kadowaki, Takashi.
- 雑誌名
- Commun Biol
- DOI
- 10.1038/s42003-021-02491-6
- PMID
- 34417555
- Online published
- 2021 Aug 20
-
Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells
- 著者
- Satoh, Kazuki., Kobayashi, Yoichi., Fujimaki, Kaori., Hayashi, Shinko., Ishida, Saori., Sugiyama, Daisuke., Sato, Takahiko., Lim, Kyungtaek., Miyamoto, Megumi., Kozuma, Shiho., Kadokura, Michinori., Wakita, Kenichi., Hata, Masato., Hirahara, Kazuki., Amano, Masato., Watanabe, Ichiro., Okamoto, Atsushi., Tuettenberg, Andrea., Jonuleit, Helmut., Tanemura, Atsushi., Maruyama, Shoichi., Agatsuma, Toshinori., Wada, Teiji., Nishikawa, Hiroyoshi.
- 雑誌名
- Int Immunol
- DOI
- 10.1093/intimm/dxab027
- PMID
- 34235533
- Online published
- 2021 Jun 03
-
Corrigendum to “Syntheses and antimicrobial activities of ogipeptin derivatives” [Bioorg. Med. Chem. Lett. 42 (2021) 128093]
- 著者
- Takiguchi, Shingo., Homma, Hidehito., Fujisawa, Tetsunori., Hirota-Takahata, Yuki., Ono, Yasunori., Kizuka, Masaaki., Ishii, Yuki., Yoshimura, Satomichi., Nishi, Takahide.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2021.128228
- PMID
- 34192636
- Online published
- 2021 Jun 27
-
Edoxaban, a direct oral factor Xa inhibitor, ameliorates coagulation, microvascular thrombus formation, and acute liver injury in a lipopolysaccharide-induced coagulopathy model in rats
- 著者
- Morishima, Yoshiyuki., Shibutani, Tomoko., Noguchi, Kengo., Ito, Yusuke., Honda, Yuko.
- 雑誌名
- J Thromb Thrombolysis
- DOI
- 10.1007/s11239-021-02381-y
- PMID
- 33534029
- Online published
- 2021 Feb 03
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Discovery of a Novel Class of ERRα Agonists
- 著者
- Shinozuka, Tsuyoshi., Ito, Shuichiro., Kimura, Takako., Izumi, Masanori., Wakabayashi, Kenji.
- 雑誌名
- ACS Med Chem Lett
- DOI
- 10.1021/acsmedchemlett.1c00100
- PMID
- 34055231
- Online published
- 2021 Apr 21
-
Syntheses and antimicrobial activities of ogipeptin derivatives
- 著者
- Takiguchi, Shingo., Homma, Hidehito., Fujisawa, Tetsunori., Hirota-Takahata, Yuki., Ono, Yasunori., Kizuka, Masaaki., Ishii, Yuki., Yoshimura, Satomichi., Nishi, Takahide.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2021.128093
- PMID
- 33964447
- Online published
- 2021 May 06
-
CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib
- 著者
- Kagiyama, Yuki., Fujita, Shuhei., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Nakagawa, Makoto., Honma, Daisuke., Adachi, Nobuaki., Araki, Kazushi., Kato, Ayako., Inaki, Koichiro., Ono, Yoshimasa., Fukuhara, Suguru., Kobayashi, Yukio., Tobinai, Kensei., Kitabayashi, Issay.
- 雑誌名
- Cancer Sci
- 巻
- 112
- ページ
- 2314-2324
- 年
- 2021
- DOI
- 10.1111/cas.14905
- PMID
- 33792119
- Online published
- 2021 May 01
-
Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate
- 著者
- Iida, Kenji., Ahmed, Amr H Abdelhamid., Nagatsuma, Akiko Kawano., Shibutani, Tomoko., Yasuda, Satoru.,
Kitamura, Michiko., Hattori, Chiharu., Abe, Manabu., Hasegawa, Jun.,
Iguchi, Takuma., Karibe, Tsuyoshi., Nakada, Takashi., Inaki, Koichiro., Kamei, Reiko., Abe, Yuki., Nomura, Taisei., Andersen, Jessica L., Santagata, Sandro., Hemming, Matthew L., George, Suzanne., Doi, Toshihiko., Ochiai, Atsushi., Demetri, George D., Agatsuma, Toshinori.
- 雑誌名
- Cancer Discov
- 巻
- 11
- ページ
- 1508-1523
- 年
- 2021
- DOI
- 10.1158/2159-8290.CD-20-1434
- PMID
- 33579785
- Online published
- 2021 Feb 12
-
Cryo-EM Structure of K +-Bound hERG Channel Complexed with the Blocker Astemizole
- 著者
- Asai, Tatsuki., Adachi, Naruhiko., Moriya, Toshio., Oki, Hideyuki., Maru, Takamitsu., Kawasaki, Masato., Suzuki, Kano., Chen, Sisi., Ishii, Ryohei., Yonemori, Kazuko., Igaki, Shigeru., Yasuda, Satoshi., Ogasawara Satoshi., Senda. Toshiya., Murata, Takeshi.
- 雑誌名
- Structure
- DOI
- 10.1016/j.str.2020.12.007
- PMID
- 33450182
- Online published
- 2021 Jan 14
-
Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions
- 著者
- Suzuki, Kyosuke., Kawakami, Kohsaku., Fukiage, Masafumi., Oikawa, Michinori., Nishida, Yohei., Matsuda, Maki., Fujita, Takuya.
- 雑誌名
- Pharmaceutics
- DOI
- 10.3390/pharmaceutics13020220
- PMID
- 33562770
- Online published
- 2021 Feb 05
-
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
- 著者
- Karlsson, Håkan K. R., Kasahara, Akiko., Ikeda, Mika., Chibalin, Alexander V., Harada, Jun., Rydén, Mikael., Krook, Anna., Kato, Mitsunori., Kubota, Kazuishi., Zierath, Juleen R.
- 雑誌名
- Metabolism
- DOI
- 10.1016/j.metabol.2021.154726
- PMID
- 33581131
- Online published
- 2021 Feb 11
-
Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease
- 著者
- Katayama, Katsushi., Ishii, Ken., Terashima, Hideki., Tsuda, Eisuke., Suzuki, Makoto., Yotsumoto, Keiichi., Hiramoto, Kumiko., Yasumatsu, Isao., Torihata, Munefumi., Ishiyama, Takashi., Muto, Tsuyoshi., Katagiri, Takahiro.
- 雑誌名
- ACS Med Chem Lett
- DOI
- 10.1021/acsmedchemlett.0c00572
- PMID
- Online published
- 2020 Dec 28
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Conformational plasticity of cyclic Ras-inhibitor peptides defines cell permeabilization activity
- 著者
- Takeuchi, Koh., Misaki, Imai., Tokunaga, Yuji., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki ., Shimada, Ichio.
- 雑誌名
- Angew Chem Int Ed Engl
- 巻
- 60
- ページ
- 6567-6572
- 年
- 2021
- DOI
- 10.1002/anie.202016647
- PMID
- 33427372
- Online published
- 2021 Jan 11
-
Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation
- 著者
- Nishimura, Masanori., Yamashita, Atsushi., Matsuura, Yunosuke., Okutsu, Junichi., Fukahori, Aiko., Hirata, Tsuyoshi., Nishizawa, Tomohiro., Ishii, Hirohito., Maekawa, Kazunari., Nakamura, Eriko., Kitamura, Kazuo., Nakamura, Kunihide., Asada, Yujiro.
- 雑誌名
- J Atheroscler Thromb
- 巻
- 28
- ページ
- 1214-1240
- 年
- 2021
- DOI
- 10.5551/jat.58248
- PMID
- 33298635
- Online published
- 2020 Dec 10
-
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
- 著者
- Guo, Chun-Jun., Chang, Fang-Yuan., Wyche, Thomas P., Backus, Keriann M., Acker, Timothy M., Funabashi, Masanori., Taketani, Mao., Donia, Mohamed S., Nayfach, Stephen., Pollard, Katherine S., Craik, Charles S., Cravatt, Benjamin F., Clardy, Jon., Voigt, Christopher A., Fischbach, Michael A.
- 雑誌名
- Cell
- DOI
- 10.1016/j.cell.2016.12.021
- PMID
- 28111075
- Online published
- 2017 Jan 19
-
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
- 著者
- Nemet, Ina., Saha, Prasenjit Prasad., Gupta, Nilaksh., Zhu, Weifei., Romano, Kymberleigh A., Skye, Sarah M., Cajka, Tomas., Mohan, Maradumane L., Li, Lin., Wu, Yuping., Funabashi, Masanori., Ramer-Tait, Amanda E., Prasad, Sathyamangla Venkata Naga., Fiehn, Oliver., Rey, Federico E., Tang, W H Wilson., Fischbach, Michael A., DiDonato, Joseph A., Hazen, Stanley L.
- 雑誌名
- Cell
- DOI
- 10.1016/j.cell.2020.02.016
- PMID
- 32142679
- Online published
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A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines
- 著者
- Ogura, Yuji., Parsons, William H., Kamat, Siddhesh S., Cravatt, Benjamin F.
- 雑誌名
- Nat Chem Biol
- DOI
- 10.1038/nchembio.2127
- PMID
- 27399000
- Online published
- 2016 Jul 11
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Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV
- 著者
- Reppas, Christos., Vrettos, Napoleon-Nikolaos., Dressman, Jennifer., Andreas, Cord J., Miyaji, Yoshihiro., Brown, Jonathan., Etherson, Kelly., Hanley, Sarah., Karkossa, Frank., Karlsson, Eva., Klein, Sandra., Maier, Gerd-Michael., McAllister, Mark., Mistry, Nena., Rosenblatt, Karin., Schäfer, Kerstin Julia., Smith, Kieran Lewis., Tomaszewska, Irena., Williams, James., Winge, Fredrik., Vertzoni Maria.
- 雑誌名
- Eur J Pharm Biopharm "
- DOI
- 10.1016/j.ejpb.2020.08.025
- PMID
- 32882421
- Online published
- 2020 Aug 31
-
Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models
- 著者
- Sasaki, Masato., Delawary, Mina., Sakurai, Hidetaka., Kobayashi, Hideki., Nakao, Naoki., Tsuru, Hiromi., Fukushima, Yumiko., Honzumi, Shoko., Moriyama, Sachiko., Wada, Naoya., Kaneko, Toshio., Yamada, Keisuke., Terasaka, Naoki., Kubota, Kazuishi.
- 雑誌名
- Arteriosclerosis, Thrombosis, and Vascular Biology
- DOI
- 10.1161/ATVBAHA.120.314516
- PMID
- 33086872
- Online published
- 2020 Oct 22
-
Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
- 著者
- Mizukoshi, Yumiko., Takeuchi, Koh., Tokunaga, Yuji., Matsuo, Hitomi., Imai, Misaki., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki., Shimada, Ichio.
- 雑誌名
- Sci. Adv.
- DOI
- 10.1126/sciadv.abd0480
- PMID
- 32998885
- Online published
- 2020 Sep 30
-
Plasma Lipid Profiling of Three Types of Drug-Induced Liver Injury in Japanese Patients: A Preliminary Study
- 著者
- Saito, Kosuke ., Kagawa, Tatehiro., Tsuji, Keiji., Kumagai, Yuji., Sato, Ken., Sakisaka, Shotaro., Sakamoto, Naoya., Aiso, Mitsuhiko., Hirose, Shunji., Mori, Nami., Tanaka, Rieko., Uraoka, Toshio., Takata, Kazuhide., Ogawa, Koji., Mori, Kazuhiko., Sato, Motonobu., Nishiya, Takayoshi., Takamatsu, Kazuhiko., Arakawa, Noriaki., Izumi, Takashi., Ohno, Yasuo., Saito, Yoshiro., Takikawa, Hajime.
- 雑誌名
- Metabolites
- DOI
- 10.3390/metabo10090355
- PMID
- 32878279
- Online published
- 2020 Aug 31
-
Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines
- 著者
- Katayama, Katsushi., Ishii, Ken., Tsuda, Eisuke., Yotsumoto, Keiichi., Hiramoto, Kumiko., Suzuki, Makoto., Yasumatsu, Isao., Igarashi, Wataru., Torihata, Munefumi., Ishiyama, Takashi., Katagiri, Takahiro.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2020.127475.
- PMID
- 32781218
- Online published
- 2020 Aug 20
-
Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells
- 著者
- Noguchi, Shingo., Ishikawa, Hirokazu., Wakita, Kenichi., Matsuda, Fumio., Shimizu, Hiroshi.
- 雑誌名
- Scientific Reports
- DOI
- 10.1038/s41598-020-70000-6
- PMID
- 32747645
- Online published
- 2020 Aug 03
-
Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine
- 著者
- Tomono, Takumi., Yagi, Haruya., Ukawa, Masami., Ishizaki, Seiya., Miwa, Takahiro., Nonomura, Mao., Igi, Ryoji., Kumagai, Hironori., Miyata, Kohei., Tobita, Etsuo., Kobayashi, Hideo., Sakuma, Shinji.
- 雑誌名
- Eur J Pharm Biopharm
- DOI
- 10.1016/j.ejpb.2020.07.003
- PMID
- 32681963
- Online published
- 2020 Jul 15
-
Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation
- 著者
- Aki, Anri., Tanaka, Kento., Nagaoka, Nobumi., Kimura, Takako., Baba, Daichi., Onodera, Yoshikuni., Wada, Teiji., Maeda, Hiroaki., Nakanishi, Toshiyuki., Agatsuma, Toshinori., Komai, Tomoaki.
- 雑誌名
- FASEB Bioadv
- DOI
- 10.1096/fba.2020-00008
- PMID
- 32821879
- Online published
- 2020 Jul 08
-
U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
- 著者
- Papadopoulos, Kyriakos P., Borazanci, Erkut., Shaw, Alice T., Katayama, Ryohei., Shimizu, Yuki., Zhu, Viola W., Sun, Thomas Yang., Wakelee, Heather A., Madison, Russell., Schrock, Alexa B., Senaldi, Giorgio., Nakao, Naoki., Hanzawa, Hiroyuki., Tachibana, Masaya., Isoyama, Takeshi., Nakamaru, Kenji., Deng, Chenhui., Li, Meijing., Fan, Frank., Zhao, Qinying., Gao, Yanfei., Seto , Takashi., Jänne, Pasi A., Ou, Sai-Hong Ignatius.
- 雑誌名
- Clin Cancer Res
- 巻
- 26
- ページ
- 4785-4794
- 年
- 2020
- DOI
- 10.1158/1078-0432.CCR-20-1630
- PMID
- Online published
- 2020 Jun 26
-
Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment
- 著者
- Brinkwirth, Nina., Takasuna, Kiyoshi., Doi, Masafumi., Becker, Nadine., Obergrussberger, Alison., Friis, Søren., Furukawa, Hatsue., Hasegawa, Yuka., Oka, Takayuki., Ohtsuki, Atsushi., Fertig, Niels., Stoelzle-Feix, Sonja.
- 雑誌名
- J Pharmacol Toxicol Methods
- DOI
- 10.1016/j.vascn.2020.106884
- PMID
- 32565325
- Online published
- 2020 Jun 18
-
The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina
- 著者
- Sayama, Ayako., Okado, Keiko., Yamaguchi, Mayu., Samata, Naozumi., Imaoka, Masako., Kai, Kiyonori., Mori, Kazuhiko.
- 雑誌名
- Toxicol Pathol
- DOI
- 10.1177/0192623320931415
- PMID
- 32538308
- Online published
- 2020 Jun 15
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A Metabolic Pathway for Bile Acid Dehydroxylation by the Gut Microbiome
- 著者
- Funabashi, Masanori., Grove, Tyler L., Wang, Min., Varma, Yug., McFadden, Molly E., Brown, Laura C., Guo, Chunjun., Higginbottom, Steven., Almo, Steven C., Fischbach, Michael A.
- 雑誌名
- Nature
- DOI
- 10.1038/s41586-020-2396-4
- PMID
- 32555455
- Online published
- 2020 Jun 17
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Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor
- 著者
- Shinozuka, Tsuyoshi., Kobayashi, Hiroyuki., Suzuki, Sayaka., Tanaka, Kyosuke., Karanjule, Narayan., Hayashi, Noriyuki., Tsuda, Toshifumi., Tokumaru, Eri., Inoue, Masahiro., Ueda, Kiyono., Kimoto, Hiroko., Domon, Yuki., Takahashi, Sakiko., Kubota, Kazufumi., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Sakakura, Tomoko., Takasuna, Kiyoshi., Abe, Yasuyuki., Watanabe, Toshiyuki., Kitano, Yutaka.
- 雑誌名
- J Med Chem
- 巻
- 63
- ページ
- 10204-10220
- 年
- 2020
- DOI
- 10.1021/acs.jmedchem.0c00259
- PMID
- 32392056
- Online published
- 2020 May 26
-
Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin With a Potential Implication of ECG Abnormalities of DMD Patients
- 著者
- Rani, Abdul Qawee Mahyoob., Yamamoto, Tetsushi., Kawaguchi, Tatsuya., Maeta, Kazuhiro., Awano, Hiroyuki., Nishio, Hisahide., Matsuo, Masafumi.
- 雑誌名
- Int J Mol Sci
- DOI
- 10.3390/ijms21103555
- PMID
- 32443516
- Online published
- 2020 May 18
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Revisiting Biomolecular NMR Spectroscopy for Promoting Small-Molecule Drug Discovery
- 著者
- Hanzawa, Hiroyuki., Shimada, Takashi., Takahashi, Mizuki., Takahashi, Hideo.
- 雑誌名
- J Biomol NMR
- DOI
- 10.1007/s10858-020-00314-0
- PMID
- 32306215
- Online published
- 2020 Apr 18
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Meta-analyses on Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Triple-Negative Breast Cancer
- 著者
- Hirai, Takehiro., Nemoto, Asuka., Ito, Yoshinor., Matsuura, Masaaki.
- 雑誌名
- Breast Cancer Res Treat
- DOI
- 10.1007/s10549-020-05615-4
- PMID
- 32246379
- Online published
- 2020 Apr 03
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Discovery of Novel Pyrrole Derivatives as Potent Agonists for the Niacin Receptor GPR109A
- 著者
- Miyazawa, Yuriko., Yamaguchi, Takahiro., Yamaguchi, Mitsuhiro., Tago, Keiko., Tamura, Akihiro., Sugiyama, Daisuke., Aburatani, Takahide., Nishizawa, Tomohiro., Kurikawa, Nobuya., Kono, Keita.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2020.127105
- PMID
- 32199732
- Online published
- 2020 Mar 10
-
Crystal Structure of the Mineralocorticoid Receptor Ligand-Binding Domain in Complex With a Potent and Selective Nonsteroidal Blocker, Esaxerenone (CS-3150)
- 著者
- Takahashi, Mizuki., Ubukata, Osamu., Homma, Tsuyoshi., Asoh, Yusuke., Honzumi Masatoshi., Hayashi, Noriyuki., Saito, Keiji., Tsuruoka, Hiroyuki., Aoki, Kazumasa., Hanzawa, Hiroyuki.
- 雑誌名
- FEBS Lett
- 巻
- 594
- ページ
- 1615-1623
- 年
- 2020
- DOI
- 10.1002/1873-3468.13746
- PMID
- 31991486
- Online published
- 2020 Feb 19
-
The Urotensin II Receptor Antagonist DS37001789 Ameliorates Mortality in Pressure-Overload Mice With Heart Failure
- 著者
- Nishi, Mina., Tagawa, Hideki., Ueno, Masumi., Marumoto, Shinji., Nagayama, Takahiro.
- 雑誌名
- Heliyon
- DOI
- 10.1016/j.heliyon.2020.e03352
- PMID
- 32055741
- Online published
- 2020 Feb 03
-
Discovery of a Novel Class of State-Dependent Na V 1.7 Inhibitors for the Treatment of Neuropathic Pain
- 著者
- Tanaka, Kyosuke., Kobayashi, Hiroyuki., Suzuki, Sayaka., Shibuya, Satoshi., Kimoto, Hiroko., Domon, Yuki., Kubota, Kazufumi., Kitano, Yutaka., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Shinozuka Tsuyoshi.
- 雑誌名
- Chem Pharm Bull (Tokyo)
- DOI
- 10.1248/cpb.c20-00126
- PMID
- 32612000
- Online published
-
An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics
- 著者
- Hansmann, Simone., Miyaji, Yoshihiro., Dressman, Jennifer.
- 雑誌名
- Eur J Pharm Biopharm
- DOI
- 10.1016/j.ejpb.2017.10.019
- PMID
- 29111469
- Online published
- 2017 Oct 27
-
Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions
- 著者
- Kawakami, Kohsaku., Suzuki, Kyosuke., Fukiage, Masafumi., Matsuda, Maki., Nishida, Yohei., Oikawa,
Michinori., Fujita, Takuya.
- 雑誌名
- Journal of Drug Delivery Science and Technology
- DOI
- 10.1016/j.jddst.2019.101172
- PMID
- Online published
- 2019 Jul 22
-
Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
- 著者
- Ohura, Kayoko., Igawa, Yoshiyuki., Tanaka, Maori., Matsumoto, Kana., Kasahara, Akiko., Wada, Naoya., Kubota, Kazuishi., Uno, Yasuhiro., Imai, Teruko.
- 雑誌名
- Drug metabolism and disposition: the biological fate of chemicals
- DOI
- 10.1124/dmd.119.089011
- PMID
- 31836607
- Online published
- 2020 Jan 30
-
Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
- 著者
- Kaji, Tomohiro., Koga, Hiroshi., Kuroha, Mutsumi., Akimoto, Toshihiko., Hayata, Kenji.
- 雑誌名
- Scientific Reports
- DOI
- 10.1038/s41598-020-59966-5
- PMID
- 32080280
- Online published
- 2020 Feb 20
-
A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model
- 著者
- Machida, Yukino., Nakagawa, Makoto., Matsunaga, Hironori., Yamaguchi, Masayuki., Ogawara, Yoko., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Hattori, Ayuna., Itoh, Masao., Seki, Takahiko., Nishiya, Yumi., Nakamura, Koichi., Suzuki, Kanae., Imaoka, Tomoki., Baba, Daichi., Suzuki, Makoto., Sampetrean, Oltea., Saya, Hideyuki., Ichimura, Koichi., Kitabayashi, Issay.
- 雑誌名
- Molecular cancer therapeutics
- DOI
- 10.1158/1535-7163.MCT-18-1349
- PMID
- 31727689
- Online published
- 2019 Nov 14
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