主な外部発表・受賞歴

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  • 主な外部発表・受賞歴

Achievements主な外部発表・受賞歴

  • Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions
    著者
    Kawakami, Kohsaku., Suzuki, Kyosuke., Fukiage, Masafumi., Matsuda, Maki., Nishida, Yohei., Oikawa, Michinori., Fujita, Takuya.
    雑誌名
    Journal of Drug Delivery Science and Technology
    56
    ページ
    101172
    2020
    DOI
    10.1016/j.jddst.2019.101172
    PMID
    Online published
    2019 Jul 22
  • Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
    著者
    Ohura, Kayoko., Igawa, Yoshiyuki., Tanaka, Maori., Matsumoto, Kana., Kasahara, Akiko., Wada, Naoya., Kubota, Kazuishi., Uno, Yasuhiro., Imai, Teruko.
    雑誌名
    Drug metabolism and disposition: the biological fate of chemicals
    48
    ページ
    146-152
    2020
    DOI
    10.1124/dmd.119.089011
    PMID
    31836607
    Online published
    2020 Jan 30
  • Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
    著者
    Kaji, Tomohiro., Koga, Hiroshi., Kuroha, Mutsumi., Akimoto, Toshihiko., Hayata, Kenji.
    雑誌名
    Scientific Reports
    10
    ページ
    3088
    2020
    DOI
    10.1038/s41598-020-59966-5
    PMID
    32080280
    Online published
    2020 Feb 20
  • A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model
    著者
    Machida, Yukino., Nakagawa, Makoto., Matsunaga, Hironori., Yamaguchi, Masayuki., Ogawara, Yoko., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Hattori, Ayuna., Itoh, Masao., Seki, Takahiko., Nishiya, Yumi., Nakamura, Koichi., Suzuki, Kanae., Imaoka, Tomoki., Baba, Daichi., Suzuki, Makoto., Sampetrean, Oltea., Saya, Hideyuki., Ichimura, Koichi., Kitabayashi, Issay.
    雑誌名
    Molecular cancer therapeutics
    19
    ページ
    375-383
    2020
    DOI
    10.1158/1535-7163.MCT-18-1349
    PMID
    31727689
    Online published
    2019 Nov 14
  • Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers
    著者
    Duisters, Kevin., Ogino, Shinji., Andou, Tomohiro., Ito, Kazumi., Akabane, Takafumi., Harms, Amy., Moerland, Matthijs., Hashimoto, Yuka., Ando, Ayumi., Ohtsu, Yoshiaki., Wada, Naoya., Yukinaga, Hideo., Meulman, Jacqueline., Kobayashi, Hiroyuki., Kobayashi, Nobuhiro., Suzumura, Kenichi., Hankemeier, Thomas.
    雑誌名
    Clinical pharmacology and therapeutics
    107
    ページ
    397-405
    2020
    DOI
    10.1002/cpt.1606
    PMID
    31400148
    Online published
    2019 Aug 10
  • Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition
    著者
    Nishiya, Yumi., Suzuki, Eiko., Ishizuka, Tomoko., Kazui, Miho., Sakurai, Hidetaka., Nakai, Daisuke.
    雑誌名
    Drug metabolism and pharmacokinetics
    35
    ページ
    45-55
    2020
    DOI
    10.1016/j.dmpk.2019.11.001
    PMID
    31926835
    Online published
    2019 Dec 24
  • Preclinical Development of U3-1784, a Novel FGFR4 Antibody against Cancer, and Avoidance of Its On-target Toxicity
    著者
    Bartz, Rene., Fukuchi, Keisuke., Ohtsuka, Toshiaki., Lange, Tanja., Gruner, Katrin., Watanabe, Ichiro., Hayashi, Shinko., Oda, Yoko., Kawaida, Reimi., Komori, Hironobu., Kashimoto, Yoshinori., Wirtz, Peter., Mayer, Jan Peter A.., Redondo-Muller, Mauricio., Saito, Shuntaro., Takahashi, Mizuki., Hanzawa, Hiroyuki., Imai, Emi., Martinez, Alberto., Hanai, Masaharu., Haussinger, Dieter., Chapman, Roger W.., Agatsuma, Toshinori., Bange, Johannes., Abraham, Reimar.
    雑誌名
    Molecular Cancer Therapeutics
    18
    ページ
    1832-1843
    2019
    DOI
    10.1158/1535-7163.MCT-18-0048
    PMID
    Online published
    2019 Jul 26
  • Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
    著者
    Kawai, Junya., Toki, Tadashi., Ota, Masahiro., Inoue, Hidekazu., Takata, Yoshimi., Asahi, Takashi., Suzuki, Makoto., Shimada, Takashi., Ono, Kaori., Suzuki, Kanae., Takaishi, Sachiko., Ohki, Hitoshi., Matsui, Satoshi., Tsutsumi, Shinji., Hirota, Yasuhide., Nakayama, Kiyoshi.
    雑誌名
    Journal of medicinal chemistry
    62
    ページ
    10204-10220
    2019
    DOI
    10.1021/acs.jmedchem.9b01113
    PMID
    31638799
    Online published
    2019 Oct 22
  • Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold
    著者
    Kawai, Junya., Ota, Masahiro., Ohki, Hitoshi., Toki, Tadashi., Suzuki, Makoto., Shimada, Takashi., Matsui, Satoshi., Inoue, Hidekazu., Sugihara, Chika., Matsuhashi, Norikazu., Matsui, Yumi., Takaishi, Sachiko., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    893-898
    2019
    DOI
    10.1021/acsmedchemlett.9b00069
    PMID
    Online published
    2019 May 24
  • Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity
    著者
    Taniguchi, Toru., Inagaki, Hiroaki., Baba, Daichi., Yasumatsu, Isao., Toyota, Akiko., Kaneta, Yasuyuki., Kiga, Masaki., Iimura, Shin., Odagiri, Takashi., Shibata, Yoshihiro., Ueda, Kiyono., Seo, Maki., Shimizu, Hiroki., Imaoka, Tomoki., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    737-742
    2019
    DOI
    10.1177/0192623318809062
    PMID
    Online published
    2019 Mar 15
  • Functional and Morphological Characteristics of Pancreatic Islet Lesions Induced by Quinolone Antimicrobial Agent Gatifloxacin in Rats
    著者
    Yabe, Koichi., Yamamoto, Yuka., Suzuki, Takami., Takada, Sanae., Mori, Kazuhiko.
    雑誌名
    Toxicologic pathology
    47
    ページ
    35-43
    2019
    DOI
    10.1177/0192623318809062
    PMID
    30407147
    Online published
    2018 Nov 08
  • Practical one-step glucuronidation via biotransformation
    著者
    Ohnuki, Takashi., Ejiri, Masahiko., Kizuka, Masaaki., Fujiwara, Mie., Nishi, Takahide.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    29
    ページ
    199-203
    2019
    DOI
    2019
    PMID
    Online published
    2018 Nov 28
  • Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones
    著者
    Komoriya, Satoshi., Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Miyauchi, Rie., Yoshida, Ken-Ichi., Kitamura, Takahiro., Takahashi, Hisashi.
    雑誌名
    Chemical & pharmaceutical bulletin
    67
    ページ
    47-58
    2019
    DOI
    10.1248/cpb.c18-00671
    PMID
    30606950
    Online published
    2019 Jan 01
  • Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma
    著者
    Nakagawa, Makoto., Fujita, Shuhei., Katsumoto, Takuo., Yamagata, Kazutsune., Ogawara, Yoko., Hattori, Ayuna., Kagiyama, Yuki., Honma, Daisuke., Araki, Kazushi., Inoue, Tatsuya., Kato, Ayako., Inaki, Koichiro., Wada, Chisa., Ono, Yoshimasa., Yamamoto, Masahide., Miura, Osamu., Nakashima, Yasuharu., Kitabayashi, Issay.
    雑誌名
    Cancer Science
    110
    ページ
    194-208
    2019
    DOI
    10.1111/cas.13840
    PMID
    30343511
    Online published
    2018 Nov 16
  • Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches
    著者
    Kubota, Kazuishi., Funabashi, Masanori., Ogura, Yuji.
    雑誌名
    Biochimica et Biophysica Acta - Proteins and Proteomics
    1867
    ページ
    22-27
    2019
    DOI
    10.1016/j.bbapap.2018.08.002
    PMID
    30392561
    Online published
  • Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology
    著者
    Ohki, Yu., Sakurai, Hidetaka., Hoshino, Madoka., Terashima, Hideki., Shimizu, Hiroki., Ishikawa, Tomio., Ogiyama, Tomoko., Muramatsu, Yasunori., Nakanishi, Toshiyuki., Miyazaki, Shojiro., Tsuruoka, Hiroyuki., Kobayashi, Hideki., Kubota, Kazuishi.
    雑誌名
    Cell chemical biology
    26
    ページ
    137-143.e8
    2019
    DOI
    10.1016/j.chembiol.2018.10.012
    PMID
    30449674
    Online published
    2018 Nov 15
  • Identification of the shortest splice variant of Dp71, together with five known variants, in glioblastoma cells
    著者
    Rani, Abdul Qawee Mahyoob., Farea, Manal., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Biochemical and Biophysical Research Communications
    508
    ページ
    640-645
    2019
    DOI
    10.1016/j.bbrc.2018.11.168
    PMID
    Online published
    2018 Dec 05
  • Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
    著者
    Terashima, Hideki., Aonuma, Misato., Tsuchida, Hiroshi., Sugimoto, Kotaro., Yokoyama, Mika., Kato, Mikio.
    雑誌名
    Pulmonary Pharmacology & Therapeutics
    54
    ページ
    31-38
    2019
    DOI
    10.1016/j.pupt.2018.11.005
    PMID
    30448291
    Online published
    2018 Nov 15
  • Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Matsui, Yumi., Wakimoto, Satoko., Ogata, Tsuneaki., Araki, Kazushi., Sawamura, Ryoko., Watanabe, Nobuaki., Mori, Makoto., Tanaka, Jun.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    358-362
    2019
    DOI
    10.1021/acsmedchemlett.8b00645
    PMID
    Online published
    2019 Feb 26
  • Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation
    著者
    Kishino, Yuki., Hasegawa, Tomoko., Kato, Ayako., Nishiya, Yumi., Rozhnal, Veronika., Watanabe, Kyoko., Takasaki, Wataru., Yamoto, Takashi., Mori, Kazuhiko.
    雑誌名
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis
    838
    ページ
    37-45
    2019
    DOI
    10.1016/j.mrgentox.2018.11.016
    PMID
    Online published
    2018 Dec 05
  • Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization
    著者
    Fujita, Yoko., Kagoshima, Yoshiko., Masuda, Takeshi., Kizuka, Masaaki., Ogawa, Yasumasa., Endo, Shuichi., Nishigoori, Hideaki., Saito, Kazuko., Takasugi, Kunio., Miura, Masami., Murakami, Ryo., Muramatsu, Yasunori., Tokumitsu, Akane., Koga, Tetsufumi., Iizuka, Mayumi., Aoyagi, Azusa., Suzuki, Toshihiro., Suzuki, Takashi., Suzuki, Yasuhiro., Ishida, Osamu., Nakahira, Toru., Miyakoshi, Shunichi., Konosu, Toshiyuki., Takatsu, Toshio.
    雑誌名
    The Journal of antibiotics
    72
    ページ
    943-955
    2019
    DOI
    10.1038/s41429-019-0215-7
    PMID
    31413314
    Online published
    2019 Aug 14
  • Schwann cell-specific Dp116 is expressed in glioblastoma cells, revealing two novel DMD gene splicing patterns
    著者
    Mahyoob Rani, Abdul Qawee., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Biochemistry and biophysics reports
    20
    ページ
    100703
    2019
    DOI
    10.1016/j.bbrep.2019.100703
    PMID
    31737793
    Online published
    2019 Nov 10
  • Muraminomicins, novel ester derivatives: in vitro and in vivo antistaphylococcal activity
    著者
    Kagoshima, Yoshiko., Tokumitsu, Akane., Masuda, Takeshi., Namba, Eiko., Inoue, Harumi., Sugihara, Chika., Yokoyama, Mizuka., Yamamoto, Yuko., Suzuki, Keiko., Iida, Kouki., Tamura, Akihiro., Fujita, Yoko., Takatsu, Toshio., Konosu, Toshiyuki., Koga, Tetsufumi.
    雑誌名
    The Journal of antibiotics
    72
    ページ
    956-969
    2019
    DOI
    10.1038/s41429-019-0235-3
    PMID
    31558775
    Online published
    2019 Sep 27
  • Harmonizing solubility measurement to lower inter-laboratory variance – progress of consortium of biopharmaceutical tools (CoBiTo) in Japan
    著者
    Ono, Asami., Matsumura, Naoya., Kimoto, Takahiro., Akiyama, Yoshiyuki., Funaki, Satoko., Tamura, Naomi., Hayashi, Shun., Kojima, Yukiko., Fushimi, Masahiro., Sudaki, Hiroshi., Aihara, Risa., Haruna, Yuka., Jiko, Maiko., Iwasaki, Masaru., Fujita, Takuya., Sugano, Kiyohiko.
    雑誌名
    ADMET & DMPK
    7
    ページ
    183-195
    2019
    DOI
    10.5599/admet.704
    PMID
    Online published
    2019 Aug 05
  • The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
    著者
    Katayama, Ryohei., Gong, Bo., Togashi, Noriko., Miyamoto, Masaya., Kiga, Masaki., Iwasaki, Shiho., Kamai, Yasuki., Tominaga, Yuichi., Takeda, Yasuyuki., Kagoshima, Yoshiko., Shimizu, Yuki., Seto, Yosuke., Oh-hara, Tomoko., Koike, Sumie., Nakao, Naoki., Hanzawa, Hiroyuki., Watanabe, Kengo., Yoda, Satoshi., Yanagitani, Noriko., Hata, Aaron N.., Shaw, Alice T.., Nishio, Makoto., Fujita, Naoya., Isoyama, Takeshi.
    雑誌名
    Nature Communications
    10
    ページ
    3604
    2019
    DOI
    10.1038/s41467-019-11496-z
    PMID
    Online published
    2019 Aug 09
  • DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model
    著者
    Jimbo, Takeshi., Hatanaka, Mana., Komatsu, Takahiro., Taira, Tomoe., Kumazawa, Kentaro., Maeda, Naoyuki., Suzuki, Takashi., Ota, Masahiro., Haginoya, Noriyasu., Isoyama, Takeshi., Fujiwara, Kosaku.
    雑誌名
    Oncotarget
    10
    ページ
    5152-5167
    2019
    DOI
    10.18632/oncotarget.27114
    PMID
    31497246
    Online published
    2019 Aug 27
  • Memantine ameliorates learning and memory disturbance and the behavioral and psychological symptoms of dementia in thiamine-deficient mice
    著者
    Makino, Mitsuhiro., Takahashi-Ito, Kaori., Murasawa, Hiroyasu., Pawlak, Akiko., Kashimoto, Yoshinori., Kitano, Yutaka.
    雑誌名
    Pharmacology Biochemistry and Behavior
    183
    ページ
    6-13
    2019
    DOI
    10.1016/j.pbb.2019.05.008
    PMID
    Online published
    2019 Jun 05
  • In Vitro Assessment of Supersaturation/Precipitation and Biological Membrane Permeation of Poorly Water-Soluble Drugs: A Case Study With Albendazole and Ketoconazole
    著者
    Kataoka, Makoto., Takeyama, Shoko., Minami, Keiko., Higashino, Haruki., Kakimi, Kohichi., Fujii, Yoshimine., Takahashi, Masayuki., Yamashita, Shinji.
    雑誌名
    Journal of Pharmaceutical Sciences
    108
    ページ
    2580-2587
    2019
    DOI
    10.1016/j.xphs.2019.03.007
    PMID
    Online published
    2019 Mar 15
  • Target identification of hepcidin production inhibitors by a combination of chemical proteomics and radioactive compound binding assay
    著者
    Sasaki, Masato., Ueda, Kenjiro., Fukuda, Takeshi., Tanaka, Naoki., Shimizu, Hiroki., Kubota, Kazuishi.
    雑誌名
    Biochemical and Biophysical Research Communications
    503
    ページ
    2878-2884
    2018
    DOI
    10.1016/j.bbrc.2018.08.061
    PMID
    Online published
    2018 Aug 21
  • Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Shimada, Kousei., Onishi, Yoshiyuki., Matsui, Yumi., Wakimoto, Satoko., Kuroha, Masanori., Ogata, Tsuneaki., Araki, Kazushi., Ohsumi, Jun., Sawamura, Ryoko., Watanabe, Nobuaki., Yamamoto, Hideki., Fujimoto, Kazunori., Tani, Yoshiro., Mori, Makoto., Tanaka, Jun.
    雑誌名
    Bioorganic and Medicinal Chemistry
    26
    ページ
    5099-5117
    2018
    DOI
    10.1016/j.bmc.2018.09.005
    PMID
    30220602
    Online published
    2018 Sep 08
  • Plasma citrulline is a sensitive safety biomarker for small intestinal injury in rats
    著者
    Saitoh, Wataru., Takada, Sanae., Hirao, Jun., Shirai, Makoto., Iguchi, Takuma., Tsuji, Makoto., Nishiya, Takayoshi., Mori, Kazuhiko.
    雑誌名
    Toxicology Letters
    295
    ページ
    416-423
    2018
    DOI
    10.1016/j.toxlet.2018.07.009
    PMID
    Online published
  • Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Shimada, Kousei., Onishi, Yoshiyuki., Matsui, Yumi., Wakimoto, Satoko., Kuroha, Masanori., Ogata, Tsuneaki., Araki, Kazushi., Ohsumi, Jun., Sawamura, Ryoko., Watanabe, Nobuaki., Yamamoto, Hideki., Fujimoto, Kazunori., Tani, Yoshiro., Mori, Makoto., Tanaka, Jun.
    雑誌名
    Bioorganic and Medicinal Chemistry
    26
    ページ
    5079-5098
    2018
    DOI
    10.1016/j.bmc.2018.09.006
    PMID
    30241907
    Online published
    2018 May 23
  • Detection of dystrophin Dp71 in human skeletal muscle using an automated capillary western assay system
    著者
    Kawaguchi, Tatsuya., Niba, Emma Tabe Eko., Rani, Abdul Qawee Mahyoob., Onishi, Yoshiyuki., Koizumi, Makoto., Awano, Hiroyuki., Matsumoto, Masaaki., Nagai, Masashi., Yoshida, Shinobu., Sakakibara, Sachiko., Maeda, Naoyuki., Sato, Osamu., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    International Journal of Molecular Sciences
    19
    ページ
    1546
    2018
    DOI
    10.3390/ijms19061546
    PMID
    Online published
    2018 May 23
  • Biocompatible Polymers Modified with d -Octaarginine as an Absorption Enhancer for Nasal Peptide Delivery
    著者
    Miyata, Kohei., Ukawa, Masami., Mohri, Kohta., Fujii, Kozue., Yamada, Mako., Tanishita, Sohei., Higashitarumi, Satoshi., Ishizaki, Seiya., Kumagai, Hironori., Ochiai, Kyohei., Hiwatari, Ken Ichiro., Tsubaki, Kazufumi., Shigeno, Koichi., Tobita, Etsuo., Kobayashi, Hideo., Sakuma, Shinji.
    雑誌名
    Bioconjugate Chemistry
    29
    ページ
    1748-1755
    2018
    DOI
    10.1021/acs.bioconjchem.8b00185
    PMID
    Online published
    2018 Apr 12
  • Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans
    著者
    Inaba, Shin-Ichi., Yamaguchi-Goto, Maki., Tanaka-Takanaka, Kaoru., Yonesu, Kiyoaki., Sakurai, Hidetaka., Kubota, Kazuishi., Izumi, Takashi.
    雑誌名
    Xenobiotica; the fate of foreign compounds in biological systems
    48
    ページ
    258-268
    2018
    DOI
    10.1080/00498254.2017.1306150
    PMID
    28287856
    Online published
    2017 Apr 03
  • A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1
    著者
    Matsui, Yumi., Yasumatsu, Isao., Yoshida, Ken Ichi., Iimura, Shin., Ikeno, Yutaka., Nawano, Takako., Fukano, Hajime., Ubukata, Osamu., Hanzawa, Hiroyuki., Tanzawa, Fumie., Isoyama, Takeshi.
    雑誌名
    Acta Crystallographica Section F: Structural Biology Communications
    74
    ページ
    156-160
    2018
    DOI
    10.1107/S2053230X18002108
    PMID
    Online published
    2018 Feb 26
  • Alkylsulfanyl analogs as potent α 2 δ ligands
    著者
    Shimada, Kousei., Ohata, Yasuo., Kobayashi, Jun., Onishi, Yoshiyuki., Kawamura, Asuka., Domon, Yuki., Arakawa, Naohisa., Inoue, Tatsuya., Kitano, Yutaka., Matsuda, Fumihiko., Abe, Yuki., Deguchi, Tsuneo.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    28
    ページ
    2000-2002
    2018
    DOI
    10.1016/j.bmcl.2018.05.006
    PMID
    Online published
    2018 May 04
  • UNC569-induced Morphological Changes in Pigment Epithelia and Photoreceptor Cells in the Retina through MerTK Inhibition in Mice
    著者
    Sayama, Ayako., Okado, Keiko., Nakamura, Koichi., Kawaguchi, Tatsuya., Iguchi, Takuma., Makino, Toshihiko., Yabe, Koichi., Kai, Kiyonori., Mori, Kazuhiko.
    雑誌名
    Toxicologic Pathology
    46
    ページ
    193-201
    2018
    DOI
    10.1177/0192623317749469
    PMID
    Online published
    2019 Jan 08
  • Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens
    著者
    Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Kitamura, Takahiro., Komoriya, Satoshi., Takahashi, Hisashi.
    雑誌名
    Journal of Medicinal Chemistry
    61
    ページ
    7234-7244
    2018
    DOI
    10.1021/acs.jmedchem.8b00644
    PMID
    Online published
    2018 Jul 31
  • Phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral doses of ds-2969b, a novel gyrb inhibitor, in healthy subjects
    著者
    Vandell, Alexander G.., Inoue, Satoshi., Dennie, Justin., Nagasawa, Yasuo., Gajee, Roohi., Pav, Joe., Zhang, George., Zamora, Cynthia., Masuda, Nobuhisa., Senaldi, Giorgio.
    雑誌名
    Antimicrobial Agents and Chemotherapy
    62
    ページ
    -
    2018
    DOI
    10.1128/AAC.02537-17
    PMID
    Online published
    2018 Apr 26
  • Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor
    著者
    Ogiyama, Tomoko., Yamaguchi, Mitsuhiro., Kurikawa, Nobuya., Honzumi, Shoko., Terayama, Koji., Nagaoka, Nobumi., Yamamoto, Yuka., Kimura, Takako., Sugiyama, Daisuke., Inoue, Shin-Ichi.
    雑誌名
    Bioorganic & medicinal chemistry
    25
    ページ
    4817-4828
    2017
    DOI
    10.1016/j.bmc.2017.07.028
    PMID
    28756012
    Online published
    2017 Jul 17
  • Pathological and gene expression analysis of a polygenic diabetes model, NONcNZO10/LtJ mice
    著者
    Hirata, Tsuyoshi., Yoshitomi, Tomomi., Inoue, Minoru., Iigo, Yutaka., Matsumoto, Koji., Kubota, Kazuishi., Shinagawa, Akira.
    雑誌名
    Gene
    629
    ページ
    52-58
    2017
    DOI
    10.1016/j.gene.2017.07.075
    PMID
    28760554
    Online published
    2017 Jul 29
  • Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor
    著者
    Honma, Daisuke., Kanno, Osamu., Watanabe, Jun., Kinoshita, Junzo., Hirasawa, Makoto., Nosaka, Emi., Shiroishi, Machiko., Takizawa, Takeshi., Yasumatsu, Isao., Horiuchi, Takao., Nakao, Akira., Suzuki, Keisuke., Yamasaki, Tomonori., Nakajima, Katsuyoshi., Hayakawa, Miho., Yamazaki, Takanori., Yadav, Ajay Singh., Adachi, Nobuaki.
    雑誌名
    Cancer science
    108
    ページ
    2069-2078
    2017
    DOI
    10.1111/cas.13326
    PMID
    28741798
    Online published
    2017 Aug 08
  • Dystrophin Dp116: A yet to Be Investigated Product of the Duchenne Muscular Dystrophy Gene
    著者
    Matsuo, Masafumi., Awano, Hiroyuki., Matsumoto, Masaaki., Nagai, Masashi., Kawaguchi, Tatsuya., Zhang, Zhujun., Nishio, Hisahide.
    雑誌名
    Genes
    8
    ページ
    251
    2017
    DOI
    10.3390/genes8100251
    PMID
    Online published
    2017 Oct 02
  • F-36316 A and B, novel vasoactive compounds, isolated from Incrucipulum sp. SANK 10414
    著者
    Hirota-Takahata, Yuki., Ishimoto, Yoko., Kurosawa, Emi., Iwadate, Yuko., Onozawa, Yoshiko., Tanaka, Isshin., Tanaka, Masahiro., Kobayashi, Hideki.
    雑誌名
    The Journal of antibiotics
    70
    ページ
    981-986
    2017
    DOI
    10.1038/ja.2017.84
    PMID
    28792011
    Online published
    2017 Aug 09
  • TLR7 mediated viral recognition results in focal type i interferon secretion by dendritic cells
    著者
    Saitoh, Shin Ichiroh., Abe, Fumiko., Kanno, Atsuo., Tanimura, Natsuko., Mori Saitoh, Yoshiko., Fukui, Ryutaro., Shibata, Takuma., Sato, Katsuaki., Ichinohe, Takeshi., Hayashi, Mayumi., Kubota, Kazuishi., Kozuka-Hata, Hiroko., Oyama, Masaaki., Kikko, Yorifumi., Katada, Toshiaki., Kontani, Kenji., Miyake, Kensuke.
    雑誌名
    Nature Communications
    8
    ページ
    1592
    2017
    DOI
    10.1038/s41467-017-01687-x
    PMID
    Online published
    2017 Nov 17
  • Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates
    著者
    Takahashi-Ito, Kaori., Makino, Mitsuhiro., Okado, Keiko., Tomita, Taisuke.
    雑誌名
    Biochemical and Biophysical Research Communications
    493
    ページ
    158-163
    2017
    DOI
    10.1016/j.bbrc.2017.09.058
    PMID
    Online published
    2017 Sep 14
  • Difference in mechanism-based inhibition of cytochrome P450 3A4 and 3A5 by a series of fluoroquinolone antibacterial agents
    著者
    Watanabe, Akiko., Takakusa, Hideo., Kimura, Takako., Inoue, Shin Ichi., Kusuhara, Hiroyuki., Ando, Osamu.
    雑誌名
    Drug Metabolism and Disposition
    45
    ページ
    336-341
    2017
    DOI
    10.1124/dmd.116.073783
    PMID
    Online published
    2016 Dec 14
  • Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking
    著者
    Ito, Kaori., Tatebe, Takuya., Suzuki, Kunimichi., Hirayama, Takashi., Hayakawa, Maki., Kubo, Hideo., Tomita, Taisuke., Makino, Mitsuhiro.
    雑誌名
    European Journal of Pharmacology
    798
    ページ
    16-25
    2017
    DOI
    10.1016/j.ejphar.2017.02.001
    PMID
    Online published
    2017 Feb 04
  • Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
    著者
    Tachida, Yuki., Izumi, Nanae., Sakurai, Toyo., Kobayashi, Hideki.
    雑誌名
    Biology open
    6
    ページ
    370-380
    2017
    DOI
    10.1242/bio.020503
    PMID
    28298363
    Online published
    2017 Mar 15