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  • Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
    著者
    Mizukoshi, Yumiko., Takeuchi, Koh., Tokunaga, Yuji., Matsuo, Hitomi., Imai, Misaki., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki., Shimada, Ichio.
    雑誌名
    Sci. Adv.
    6
    ページ
    eabd0480
    2020
    DOI
    10.1126/sciadv.abd0480
    PMID
    32998885
    Online published
    2020 Sep 30
  • Plasma Lipid Profiling of Three Types of Drug-Induced Liver Injury in Japanese Patients: A Preliminary Study
    著者
    Saito, Kosuke ., Kagawa, Tatehiro., Tsuji, Keiji., Kumagai, Yuji., Sato, Ken., Sakisaka, Shotaro., Sakamoto, Naoya., Aiso, Mitsuhiko., Hirose, Shunji., Mori, Nami., Tanaka, Rieko., Uraoka, Toshio., Takata, Kazuhide., Ogawa, Koji., Mori, Kazuhiko., Sato, Motonobu., Nishiya, Takayoshi., Takamatsu, Kazuhiko., Arakawa, Noriaki., Izumi, Takashi., Ohno, Yasuo., Saito, Yoshiro., Takikawa, Hajime.
    雑誌名
    Metabolites
    10
    ページ
    E355
    2020
    DOI
    10.3390/metabo10090355
    PMID
    32878279
    Online published
    2020 Aug 31
  • Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines
    著者
    Katayama, Katsushi., Ishii, Ken., Tsuda, Eisuke., Yotsumoto, Keiichi., Hiramoto, Kumiko., Suzuki, Makoto., Yasumatsu, Isao., Igarashi, Wataru., Torihata, Munefumi., Ishiyama, Takashi., Katagiri, Takahiro.
    雑誌名
    Bioorg Med Chem Lett
    30
    ページ
    127475
    2020
    DOI
    10.1016/j.bmcl.2020.127475.
    PMID
    32781218
    Online published
    2020 Aug 20
  • Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells
    著者
    Noguchi, Shingo., Ishikawa, Hirokazu., Wakita, Kenichi., Matsuda, Fumio., Shimizu, Hiroshi.
    雑誌名
    Scientific Reports
    10
    ページ
    13065
    2020
    DOI
    10.1038/s41598-020-70000-6
    PMID
    32747645
    Online published
    2020 Aug 03
  • Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine
    著者
    Tomono, Takumi., Yagi, Haruya., Ukawa, Masami., Ishizaki, Seiya., Miwa, Takahiro., Nonomura, Mao., Igi, Ryoji., Kumagai, Hironori., Miyata, Kohei., Tobita, Etsuo., Kobayashi, Hideo., Sakuma, Shinji.
    雑誌名
    Eur J Pharm Biopharm
    154
    ページ
    186-194
    2020
    DOI
    10.1016/j.ejpb.2020.07.003
    PMID
    32681963
    Online published
    2020 Jul 15
  • Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation
    著者
    Aki, Anri., Tanaka, Kento., Nagaoka, Nobumi., Kimura, Takako., Baba, Daichi., Onodera, Yoshikuni., Wada, Teiji., Maeda, Hiroaki., Nakanishi, Toshiyuki., Agatsuma, Toshinori., Komai, Tomoaki.
    雑誌名
    FASEB Bioadv
    2
    ページ
    478–488
    2020
    DOI
    10.1096/fba.2020-00008
    PMID
    32821879
    Online published
    2020 Jul 08
  • U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
    著者
    Papadopoulos, Kyriakos P., Borazanci, Erkut., Shaw, Alice T., Katayama, Ryohei., Shimizu, Yuki., Zhu, Viola W., Sun, Thomas Yang., Wakelee, Heather A., Madison, Russell., Schrock, Alexa B., Senaldi, Giorgio., Nakao, Naoki., Hanzawa, Hiroyuki., Tachibana, Masaya., Isoyama, Takeshi., Nakamaru, Kenji., Deng, Chenhui., Li, Meijing., Fan, Frank., Zhao, Qinying., Gao, Yanfei., Seto , Takashi., Jänne, Pasi A., Ou, Sai-Hong Ignatius.
    雑誌名
    Clin Cancer Res
    Online ahead of print
    ページ
    2020
    DOI
    10.1158/1078-0432.CCR-20-1630
    PMID
    Online published
    2020 Aug 05
  • Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment
    著者
    Brinkwirth, Nina., Takasuna, Kiyoshi., Doi, Masafumi., Becker, Nadine., Obergrussberger, Alison., Friis, Søren., Furukawa, Hatsue., Hasegawa, Yuka., Oka, Takayuki., Ohtsuki, Atsushi., Fertig, Niels., Stoelzle-Feix, Sonja.
    雑誌名
    J Pharmacol Toxicol Methods
    Online ahead of print
    ページ
    2020
    DOI
    10.1016/j.vascn.2020.106884
    PMID
    32565325
    Online published
    2020 Jun 18
  • The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina
    著者
    Sayama, Ayako., Okado, Keiko., Yamaguchi, Mayu., Samata, Naozumi., Imaoka, Masako., Kai, Kiyonori., Mori, Kazuhiko.
    雑誌名
    Toxicol Pathol
    48
    ページ
    669-676
    2020
    DOI
    10.1177/0192623320931415
    PMID
    32538308
    Online published
    2020 Jun 15
  • A Metabolic Pathway for Bile Acid Dehydroxylation by the Gut Microbiome
    著者
    Funabashi, Masanori., Grove, Tyler L., Wang, Min., Varma, Yug., McFadden, Molly E., Brown, Laura C., Guo, Chunjun., Higginbottom, Steven., Almo, Steven C., Fischbach, Michael A.
    雑誌名
    Nature
    582
    ページ
    566-570
    2020
    DOI
    10.1038/s41586-020-2396-4
    PMID
    32555455
    Online published
    2020 Jun 17
  • Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor
    著者
    Shinozuka, Tsuyoshi., Kobayashi, Hiroyuki., Suzuki, Sayaka., Tanaka, Kyosuke., Karanjule, Narayan., Hayashi, Noriyuki., Tsuda, Toshifumi., Tokumaru, Eri., Inoue, Masahiro., Ueda, Kiyono., Kimoto, Hiroko., Domon, Yuki., Takahashi, Sakiko., Kubota, Kazufumi., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Sakakura, Tomoko., Takasuna, Kiyoshi., Abe, Yasuyuki., Watanabe, Toshiyuki., Kitano, Yutaka.
    雑誌名
    J Med Chem
    Online ahead of print
    ページ
    2020
    DOI
    10.1021/acs.jmedchem.0c00259
    PMID
    32392056
    Online published
    2020 May 26
  • Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin With a Potential Implication of ECG Abnormalities of DMD Patients
    著者
    Rani, Abdul Qawee Mahyoob., Yamamoto, Tetsushi., Kawaguchi, Tatsuya., Maeta, Kazuhiro., Awano, Hiroyuki., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Int J Mol Sci
    21
    ページ
    3555
    2020
    DOI
    10.3390/ijms21103555
    PMID
    32443516
    Online published
    2020 May 18
  • Revisiting Biomolecular NMR Spectroscopy for Promoting Small-Molecule Drug Discovery
    著者
    Hanzawa, Hiroyuki., Shimada, Takashi., Takahashi, Mizuki., Takahashi, Hideo.
    雑誌名
    J Biomol NMR
    Online ahead of print
    ページ
    2020
    DOI
    10.1007/s10858-020-00314-0
    PMID
    32306215
    Online published
    2020 Apr 18
  • Meta-analyses on Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Triple-Negative Breast Cancer
    著者
    Hirai, Takehiro., Nemoto, Asuka., Ito, Yoshinor., Matsuura, Masaaki.
    雑誌名
    Breast Cancer Res Treat
    181
    ページ
    189-198
    2020
    DOI
    10.1007/s10549-020-05615-4
    PMID
    32246379
    Online published
    2020 Apr 03
  • Discovery of Novel Pyrrole Derivatives as Potent Agonists for the Niacin Receptor GPR109A
    著者
    Miyazawa, Yuriko., Yamaguchi, Takahiro., Yamaguchi, Mitsuhiro., Tago, Keiko., Tamura, Akihiro., Sugiyama, Daisuke., Aburatani, Takahide., Nishizawa, Tomohiro., Kurikawa, Nobuya., Kono, Keita.
    雑誌名
    Bioorg Med Chem Lett
    30
    ページ
    127105
    2020
    DOI
    10.1016/j.bmcl.2020.127105
    PMID
    32199732
    Online published
    2020 Mar 10
  • Crystal Structure of the Mineralocorticoid Receptor Ligand-Binding Domain in Complex With a Potent and Selective Nonsteroidal Blocker, Esaxerenone (CS-3150)
    著者
    Takahashi, Mizuki., Ubukata, Osamu., Homma, Tsuyoshi., Asoh, Yusuke., Honzumi Masatoshi., Hayashi, Noriyuki., Saito, Keiji., Tsuruoka, Hiroyuki., Aoki, Kazumasa., Hanzawa, Hiroyuki.
    雑誌名
    FEBS Lett
    594
    ページ
    1615-1623
    2020
    DOI
    10.1002/1873-3468.13746
    PMID
    31991486
    Online published
    2020 Feb 19
  • The Urotensin II Receptor Antagonist DS37001789 Ameliorates Mortality in Pressure-Overload Mice With Heart Failure
    著者
    Nishi, Mina., Tagawa, Hideki., Ueno, Masumi., Marumoto, Shinji., Nagayama, Takahiro.
    雑誌名
    Heliyon
    6
    ページ
    e03352
    2020
    DOI
    10.1016/j.heliyon.2020.e03352
    PMID
    32055741
    Online published
    2020 Feb 03
  • Discovery of a Novel Class of State-Dependent Na V 1.7 Inhibitors for the Treatment of Neuropathic Pain
    著者
    Tanaka, Kyosuke., Kobayashi, Hiroyuki., Suzuki, Sayaka., Shibuya, Satoshi., Kimoto, Hiroko., Domon, Yuki., Kubota, Kazufumi., Kitano, Yutaka., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Shinozuka Tsuyoshi.
    雑誌名
    Chem Pharm Bull (Tokyo)
    68
    ページ
    653-663
    2020
    DOI
    10.1248/cpb.c20-00126
    PMID
    32612000
    Online published
  • An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics
    著者
    Hansmann, Simone., Miyaji, Yoshihiro., Dressman, Jennifer.
    雑誌名
    Eur J Pharm Biopharm
    122
    ページ
    186-196
    2018
    DOI
    10.1016/j.ejpb.2017.10.019
    PMID
    29111469
    Online published
    2017 Oct 27
  • Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions
    著者
    Kawakami, Kohsaku., Suzuki, Kyosuke., Fukiage, Masafumi., Matsuda, Maki., Nishida, Yohei., Oikawa, Michinori., Fujita, Takuya.
    雑誌名
    Journal of Drug Delivery Science and Technology
    56
    ページ
    101172
    2020
    DOI
    10.1016/j.jddst.2019.101172
    PMID
    Online published
    2019 Jul 22
  • Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
    著者
    Ohura, Kayoko., Igawa, Yoshiyuki., Tanaka, Maori., Matsumoto, Kana., Kasahara, Akiko., Wada, Naoya., Kubota, Kazuishi., Uno, Yasuhiro., Imai, Teruko.
    雑誌名
    Drug metabolism and disposition: the biological fate of chemicals
    48
    ページ
    146-152
    2020
    DOI
    10.1124/dmd.119.089011
    PMID
    31836607
    Online published
    2020 Jan 30
  • Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
    著者
    Kaji, Tomohiro., Koga, Hiroshi., Kuroha, Mutsumi., Akimoto, Toshihiko., Hayata, Kenji.
    雑誌名
    Scientific Reports
    10
    ページ
    3088
    2020
    DOI
    10.1038/s41598-020-59966-5
    PMID
    32080280
    Online published
    2020 Feb 20
  • A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model
    著者
    Machida, Yukino., Nakagawa, Makoto., Matsunaga, Hironori., Yamaguchi, Masayuki., Ogawara, Yoko., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Hattori, Ayuna., Itoh, Masao., Seki, Takahiko., Nishiya, Yumi., Nakamura, Koichi., Suzuki, Kanae., Imaoka, Tomoki., Baba, Daichi., Suzuki, Makoto., Sampetrean, Oltea., Saya, Hideyuki., Ichimura, Koichi., Kitabayashi, Issay.
    雑誌名
    Molecular cancer therapeutics
    19
    ページ
    375-383
    2020
    DOI
    10.1158/1535-7163.MCT-18-1349
    PMID
    31727689
    Online published
    2019 Nov 14
  • Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers
    著者
    Duisters, Kevin., Ogino, Shinji., Andou, Tomohiro., Ito, Kazumi., Akabane, Takafumi., Harms, Amy., Moerland, Matthijs., Hashimoto, Yuka., Ando, Ayumi., Ohtsu, Yoshiaki., Wada, Naoya., Yukinaga, Hideo., Meulman, Jacqueline., Kobayashi, Hiroyuki., Kobayashi, Nobuhiro., Suzumura, Kenichi., Hankemeier, Thomas.
    雑誌名
    Clinical pharmacology and therapeutics
    107
    ページ
    397-405
    2020
    DOI
    10.1002/cpt.1606
    PMID
    31400148
    Online published
    2019 Aug 10
  • Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition
    著者
    Nishiya, Yumi., Suzuki, Eiko., Ishizuka, Tomoko., Kazui, Miho., Sakurai, Hidetaka., Nakai, Daisuke.
    雑誌名
    Drug metabolism and pharmacokinetics
    35
    ページ
    45-55
    2020
    DOI
    10.1016/j.dmpk.2019.11.001
    PMID
    31926835
    Online published
    2019 Dec 24
  • Preclinical Development of U3-1784, a Novel FGFR4 Antibody against Cancer, and Avoidance of Its On-target Toxicity
    著者
    Bartz, Rene., Fukuchi, Keisuke., Ohtsuka, Toshiaki., Lange, Tanja., Gruner, Katrin., Watanabe, Ichiro., Hayashi, Shinko., Oda, Yoko., Kawaida, Reimi., Komori, Hironobu., Kashimoto, Yoshinori., Wirtz, Peter., Mayer, Jan Peter A.., Redondo-Muller, Mauricio., Saito, Shuntaro., Takahashi, Mizuki., Hanzawa, Hiroyuki., Imai, Emi., Martinez, Alberto., Hanai, Masaharu., Haussinger, Dieter., Chapman, Roger W.., Agatsuma, Toshinori., Bange, Johannes., Abraham, Reimar.
    雑誌名
    Molecular Cancer Therapeutics
    18
    ページ
    1832-1843
    2019
    DOI
    10.1158/1535-7163.MCT-18-0048
    PMID
    Online published
    2019 Jul 26
  • Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
    著者
    Kawai, Junya., Toki, Tadashi., Ota, Masahiro., Inoue, Hidekazu., Takata, Yoshimi., Asahi, Takashi., Suzuki, Makoto., Shimada, Takashi., Ono, Kaori., Suzuki, Kanae., Takaishi, Sachiko., Ohki, Hitoshi., Matsui, Satoshi., Tsutsumi, Shinji., Hirota, Yasuhide., Nakayama, Kiyoshi.
    雑誌名
    Journal of medicinal chemistry
    62
    ページ
    10204-10220
    2019
    DOI
    10.1021/acs.jmedchem.9b01113
    PMID
    31638799
    Online published
    2019 Oct 22
  • Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold
    著者
    Kawai, Junya., Ota, Masahiro., Ohki, Hitoshi., Toki, Tadashi., Suzuki, Makoto., Shimada, Takashi., Matsui, Satoshi., Inoue, Hidekazu., Sugihara, Chika., Matsuhashi, Norikazu., Matsui, Yumi., Takaishi, Sachiko., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    893-898
    2019
    DOI
    10.1021/acsmedchemlett.9b00069
    PMID
    Online published
    2019 May 24
  • Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity
    著者
    Taniguchi, Toru., Inagaki, Hiroaki., Baba, Daichi., Yasumatsu, Isao., Toyota, Akiko., Kaneta, Yasuyuki., Kiga, Masaki., Iimura, Shin., Odagiri, Takashi., Shibata, Yoshihiro., Ueda, Kiyono., Seo, Maki., Shimizu, Hiroki., Imaoka, Tomoki., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    737-742
    2019
    DOI
    10.1177/0192623318809062
    PMID
    Online published
    2019 Mar 15
  • Functional and Morphological Characteristics of Pancreatic Islet Lesions Induced by Quinolone Antimicrobial Agent Gatifloxacin in Rats
    著者
    Yabe, Koichi., Yamamoto, Yuka., Suzuki, Takami., Takada, Sanae., Mori, Kazuhiko.
    雑誌名
    Toxicologic pathology
    47
    ページ
    35-43
    2019
    DOI
    10.1177/0192623318809062
    PMID
    30407147
    Online published
    2018 Nov 08
  • Practical one-step glucuronidation via biotransformation
    著者
    Ohnuki, Takashi., Ejiri, Masahiko., Kizuka, Masaaki., Fujiwara, Mie., Nishi, Takahide.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    29
    ページ
    199-203
    2019
    DOI
    2019
    PMID
    Online published
    2018 Nov 28
  • Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones
    著者
    Komoriya, Satoshi., Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Miyauchi, Rie., Yoshida, Ken-Ichi., Kitamura, Takahiro., Takahashi, Hisashi.
    雑誌名
    Chemical & pharmaceutical bulletin
    67
    ページ
    47-58
    2019
    DOI
    10.1248/cpb.c18-00671
    PMID
    30606950
    Online published
    2019 Jan 01
  • Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma
    著者
    Nakagawa, Makoto., Fujita, Shuhei., Katsumoto, Takuo., Yamagata, Kazutsune., Ogawara, Yoko., Hattori, Ayuna., Kagiyama, Yuki., Honma, Daisuke., Araki, Kazushi., Inoue, Tatsuya., Kato, Ayako., Inaki, Koichiro., Wada, Chisa., Ono, Yoshimasa., Yamamoto, Masahide., Miura, Osamu., Nakashima, Yasuharu., Kitabayashi, Issay.
    雑誌名
    Cancer Science
    110
    ページ
    194-208
    2019
    DOI
    10.1111/cas.13840
    PMID
    30343511
    Online published
    2018 Nov 16
  • Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches
    著者
    Kubota, Kazuishi., Funabashi, Masanori., Ogura, Yuji.
    雑誌名
    Biochimica et Biophysica Acta - Proteins and Proteomics
    1867
    ページ
    22-27
    2019
    DOI
    10.1016/j.bbapap.2018.08.002
    PMID
    30392561
    Online published
  • Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology
    著者
    Ohki, Yu., Sakurai, Hidetaka., Hoshino, Madoka., Terashima, Hideki., Shimizu, Hiroki., Ishikawa, Tomio., Ogiyama, Tomoko., Muramatsu, Yasunori., Nakanishi, Toshiyuki., Miyazaki, Shojiro., Tsuruoka, Hiroyuki., Kobayashi, Hideki., Kubota, Kazuishi.
    雑誌名
    Cell chemical biology
    26
    ページ
    137-143.e8
    2019
    DOI
    10.1016/j.chembiol.2018.10.012
    PMID
    30449674
    Online published
    2018 Nov 15
  • Identification of the shortest splice variant of Dp71, together with five known variants, in glioblastoma cells
    著者
    Rani, Abdul Qawee Mahyoob., Farea, Manal., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Biochemical and Biophysical Research Communications
    508
    ページ
    640-645
    2019
    DOI
    10.1016/j.bbrc.2018.11.168
    PMID
    Online published
    2018 Dec 05
  • Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
    著者
    Terashima, Hideki., Aonuma, Misato., Tsuchida, Hiroshi., Sugimoto, Kotaro., Yokoyama, Mika., Kato, Mikio.
    雑誌名
    Pulmonary Pharmacology & Therapeutics
    54
    ページ
    31-38
    2019
    DOI
    10.1016/j.pupt.2018.11.005
    PMID
    30448291
    Online published
    2018 Nov 15
  • Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Matsui, Yumi., Wakimoto, Satoko., Ogata, Tsuneaki., Araki, Kazushi., Sawamura, Ryoko., Watanabe, Nobuaki., Mori, Makoto., Tanaka, Jun.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    358-362
    2019
    DOI
    10.1021/acsmedchemlett.8b00645
    PMID
    Online published
    2019 Feb 26
  • Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation
    著者
    Kishino, Yuki., Hasegawa, Tomoko., Kato, Ayako., Nishiya, Yumi., Rozhnal, Veronika., Watanabe, Kyoko., Takasaki, Wataru., Yamoto, Takashi., Mori, Kazuhiko.
    雑誌名
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis
    838
    ページ
    37-45
    2019
    DOI
    10.1016/j.mrgentox.2018.11.016
    PMID
    Online published
    2018 Dec 05
  • Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization
    著者
    Fujita, Yoko., Kagoshima, Yoshiko., Masuda, Takeshi., Kizuka, Masaaki., Ogawa, Yasumasa., Endo, Shuichi., Nishigoori, Hideaki., Saito, Kazuko., Takasugi, Kunio., Miura, Masami., Murakami, Ryo., Muramatsu, Yasunori., Tokumitsu, Akane., Koga, Tetsufumi., Iizuka, Mayumi., Aoyagi, Azusa., Suzuki, Toshihiro., Suzuki, Takashi., Suzuki, Yasuhiro., Ishida, Osamu., Nakahira, Toru., Miyakoshi, Shunichi., Konosu, Toshiyuki., Takatsu, Toshio.
    雑誌名
    The Journal of antibiotics
    72
    ページ
    943-955
    2019
    DOI
    10.1038/s41429-019-0215-7
    PMID
    31413314
    Online published
    2019 Aug 14
  • Schwann cell-specific Dp116 is expressed in glioblastoma cells, revealing two novel DMD gene splicing patterns
    著者
    Mahyoob Rani, Abdul Qawee., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Biochemistry and biophysics reports
    20
    ページ
    100703
    2019
    DOI
    10.1016/j.bbrep.2019.100703
    PMID
    31737793
    Online published
    2019 Nov 10
  • Muraminomicins, novel ester derivatives: in vitro and in vivo antistaphylococcal activity
    著者
    Kagoshima, Yoshiko., Tokumitsu, Akane., Masuda, Takeshi., Namba, Eiko., Inoue, Harumi., Sugihara, Chika., Yokoyama, Mizuka., Yamamoto, Yuko., Suzuki, Keiko., Iida, Kouki., Tamura, Akihiro., Fujita, Yoko., Takatsu, Toshio., Konosu, Toshiyuki., Koga, Tetsufumi.
    雑誌名
    The Journal of antibiotics
    72
    ページ
    956-969
    2019
    DOI
    10.1038/s41429-019-0235-3
    PMID
    31558775
    Online published
    2019 Sep 27
  • Harmonizing solubility measurement to lower inter-laboratory variance – progress of consortium of biopharmaceutical tools (CoBiTo) in Japan
    著者
    Ono, Asami., Matsumura, Naoya., Kimoto, Takahiro., Akiyama, Yoshiyuki., Funaki, Satoko., Tamura, Naomi., Hayashi, Shun., Kojima, Yukiko., Fushimi, Masahiro., Sudaki, Hiroshi., Aihara, Risa., Haruna, Yuka., Jiko, Maiko., Iwasaki, Masaru., Fujita, Takuya., Sugano, Kiyohiko.
    雑誌名
    ADMET & DMPK
    7
    ページ
    183-195
    2019
    DOI
    10.5599/admet.704
    PMID
    Online published
    2019 Aug 05
  • The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
    著者
    Katayama, Ryohei., Gong, Bo., Togashi, Noriko., Miyamoto, Masaya., Kiga, Masaki., Iwasaki, Shiho., Kamai, Yasuki., Tominaga, Yuichi., Takeda, Yasuyuki., Kagoshima, Yoshiko., Shimizu, Yuki., Seto, Yosuke., Oh-hara, Tomoko., Koike, Sumie., Nakao, Naoki., Hanzawa, Hiroyuki., Watanabe, Kengo., Yoda, Satoshi., Yanagitani, Noriko., Hata, Aaron N.., Shaw, Alice T.., Nishio, Makoto., Fujita, Naoya., Isoyama, Takeshi.
    雑誌名
    Nature Communications
    10
    ページ
    3604
    2019
    DOI
    10.1038/s41467-019-11496-z
    PMID
    Online published
    2019 Aug 09
  • DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model
    著者
    Jimbo, Takeshi., Hatanaka, Mana., Komatsu, Takahiro., Taira, Tomoe., Kumazawa, Kentaro., Maeda, Naoyuki., Suzuki, Takashi., Ota, Masahiro., Haginoya, Noriyasu., Isoyama, Takeshi., Fujiwara, Kosaku.
    雑誌名
    Oncotarget
    10
    ページ
    5152-5167
    2019
    DOI
    10.18632/oncotarget.27114
    PMID
    31497246
    Online published
    2019 Aug 27
  • Memantine ameliorates learning and memory disturbance and the behavioral and psychological symptoms of dementia in thiamine-deficient mice
    著者
    Makino, Mitsuhiro., Takahashi-Ito, Kaori., Murasawa, Hiroyasu., Pawlak, Akiko., Kashimoto, Yoshinori., Kitano, Yutaka.
    雑誌名
    Pharmacology Biochemistry and Behavior
    183
    ページ
    6-13
    2019
    DOI
    10.1016/j.pbb.2019.05.008
    PMID
    Online published
    2019 Jun 05
  • In Vitro Assessment of Supersaturation/Precipitation and Biological Membrane Permeation of Poorly Water-Soluble Drugs: A Case Study With Albendazole and Ketoconazole
    著者
    Kataoka, Makoto., Takeyama, Shoko., Minami, Keiko., Higashino, Haruki., Kakimi, Kohichi., Fujii, Yoshimine., Takahashi, Masayuki., Yamashita, Shinji.
    雑誌名
    Journal of Pharmaceutical Sciences
    108
    ページ
    2580-2587
    2019
    DOI
    10.1016/j.xphs.2019.03.007
    PMID
    Online published
    2019 Mar 15
  • Target identification of hepcidin production inhibitors by a combination of chemical proteomics and radioactive compound binding assay
    著者
    Sasaki, Masato., Ueda, Kenjiro., Fukuda, Takeshi., Tanaka, Naoki., Shimizu, Hiroki., Kubota, Kazuishi.
    雑誌名
    Biochemical and Biophysical Research Communications
    503
    ページ
    2878-2884
    2018
    DOI
    10.1016/j.bbrc.2018.08.061
    PMID
    Online published
    2018 Aug 21
  • Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Shimada, Kousei., Onishi, Yoshiyuki., Matsui, Yumi., Wakimoto, Satoko., Kuroha, Masanori., Ogata, Tsuneaki., Araki, Kazushi., Ohsumi, Jun., Sawamura, Ryoko., Watanabe, Nobuaki., Yamamoto, Hideki., Fujimoto, Kazunori., Tani, Yoshiro., Mori, Makoto., Tanaka, Jun.
    雑誌名
    Bioorganic and Medicinal Chemistry
    26
    ページ
    5099-5117
    2018
    DOI
    10.1016/j.bmc.2018.09.005
    PMID
    30220602
    Online published
    2018 Sep 08
  • Plasma citrulline is a sensitive safety biomarker for small intestinal injury in rats
    著者
    Saitoh, Wataru., Takada, Sanae., Hirao, Jun., Shirai, Makoto., Iguchi, Takuma., Tsuji, Makoto., Nishiya, Takayoshi., Mori, Kazuhiko.
    雑誌名
    Toxicology Letters
    295
    ページ
    416-423
    2018
    DOI
    10.1016/j.toxlet.2018.07.009
    PMID
    Online published