-
Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease
- 著者
- Katayama, Katsushi., Ishii, Ken., Terashima, Hideki., Tsuda, Eisuke., Suzuki, Makoto., Yotsumoto, Keiichi., Hiramoto, Kumiko., Yasumatsu, Isao., Torihata, Munefumi., Ishiyama, Takashi., Muto, Tsuyoshi., Katagiri, Takahiro.
- 雑誌名
- ACS Med Chem Lett
- DOI
- 10.1021/acsmedchemlett.0c00572
- PMID
- Online published
- 2020 Dec 28
-
Conformational plasticity of cyclic Ras-inhibitor peptides defines cell permeabilization activity
- 著者
- Takeuchi, Koh., Misaki, Imai., Tokunaga, Yuji., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki ., Shimada, Ichio.
- 雑誌名
- Angew Chem Int Ed Engl
- 巻
- Online ahead of print
- ページ
- Online ahead of print
- 年
- 2021
- DOI
- 10.1002/anie.202016647
- PMID
- 33427372
- Online published
- 2021 Jan 11
-
NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein
- 著者
- Yanaka, Saeko., Yamaguchi, Yoshiki., Takizawa, Takeshi., Miyanoiri, Yohei., Yogo, Rina., Shimada, Ichio., Kato, Koichi.
- 雑誌名
- Biomol NMR Assign
- 巻
- Online ahead of print
- ページ
- Online ahead of print
- 年
- 2021
- DOI
- 10.1007/s12104-020-10004-5
- PMID
- 33423189
- Online published
- 2021 Jan 10
-
Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation
- 著者
- Nishimura, Masanori., Yamashita, Atsushi., Matsuura, Yunosuke., Okutsu, Junichi., Fukahori, Aiko., Hirata, Tsuyoshi., Nishizawa, Tomohiro., Ishii, Hirohito., Maekawa, Kazunari., Nakamura, Eriko., Kitamura, Kazuo., Nakamura, Kunihide., Asada, Yujiro.
- 雑誌名
- J Atheroscler Thromb"
- 巻
- Online ahead of print
- ページ
- Online ahead of print
- 年
- 2020
- DOI
- 10.5551/jat.58248
- PMID
- 33298635
- Online published
- 2020 Dec 10
-
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
- 著者
- Guo, Chun-Jun., Chang, Fang-Yuan., Wyche, Thomas P., Backus, Keriann M., Acker, Timothy M., Funabashi, Masanori., Taketani, Mao., Donia, Mohamed S., Nayfach, Stephen., Pollard, Katherine S., Craik, Charles S., Cravatt, Benjamin F., Clardy, Jon., Voigt, Christopher A., Fischbach, Michael A.
- 雑誌名
- Cell
- DOI
- 10.1016/j.cell.2016.12.021
- PMID
- 28111075
- Online published
- 2017 Jan 19
-
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
- 著者
- Nemet, Ina., Saha, Prasenjit Prasad., Gupta, Nilaksh., Zhu, Weifei., Romano, Kymberleigh A., Skye, Sarah M., Cajka, Tomas., Mohan, Maradumane L., Li, Lin., Wu, Yuping., Funabashi, Masanori., Ramer-Tait, Amanda E., Prasad, Sathyamangla Venkata Naga., Fiehn, Oliver., Rey, Federico E., Tang, W H Wilson., Fischbach, Michael A., DiDonato, Joseph A., Hazen, Stanley L.
- 雑誌名
- Cell
- DOI
- 10.1016/j.cell.2020.02.016
- PMID
- 32142679
- Online published
-
A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines
- 著者
- Ogura, Yuji., Parsons, William H., Kamat, Siddhesh S., Cravatt, Benjamin F.
- 雑誌名
- Nat Chem Biol
- DOI
- 10.1038/nchembio.2127
- PMID
- 27399000
- Online published
- 2016 Jul 11
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Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV
- 著者
- Reppas, Christos., Vrettos, Napoleon-Nikolaos., Dressman, Jennifer., Andreas, Cord J., Miyaji, Yoshihiro., Brown, Jonathan., Etherson, Kelly., Hanley, Sarah., Karkossa, Frank., Karlsson, Eva., Klein, Sandra., Maier, Gerd-Michael., McAllister, Mark., Mistry, Nena., Rosenblatt, Karin., Schäfer, Kerstin Julia., Smith, Kieran Lewis., Tomaszewska, Irena., Williams, James., Winge, Fredrik., Vertzoni Maria.
- 雑誌名
- Eur J Pharm Biopharm "
- DOI
- 10.1016/j.ejpb.2020.08.025
- PMID
- 32882421
- Online published
- 2020 Aug 31
-
Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models
- 著者
- Sasaki, Masato., Delawary, Mina., Sakurai, Hidetaka., Kobayashi, Hideki., Nakao, Naoki., Tsuru, Hiromi., Fukushima, Yumiko., Honzumi, Shoko., Moriyama, Sachiko., Wada, Naoya., Kaneko, Toshio., Yamada, Keisuke., Terasaka, Naoki., Kubota, Kazuishi.
- 雑誌名
- Arteriosclerosis, Thrombosis, and Vascular Biology
- DOI
- 10.1161/ATVBAHA.120.314516
- PMID
- 33086872
- Online published
- 2020 Oct 22
-
Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
- 著者
- Mizukoshi, Yumiko., Takeuchi, Koh., Tokunaga, Yuji., Matsuo, Hitomi., Imai, Misaki., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki., Shimada, Ichio.
- 雑誌名
- Sci. Adv.
- DOI
- 10.1126/sciadv.abd0480
- PMID
- 32998885
- Online published
- 2020 Sep 30
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Plasma Lipid Profiling of Three Types of Drug-Induced Liver Injury in Japanese Patients: A Preliminary Study
- 著者
- Saito, Kosuke ., Kagawa, Tatehiro., Tsuji, Keiji., Kumagai, Yuji., Sato, Ken., Sakisaka, Shotaro., Sakamoto, Naoya., Aiso, Mitsuhiko., Hirose, Shunji., Mori, Nami., Tanaka, Rieko., Uraoka, Toshio., Takata, Kazuhide., Ogawa, Koji., Mori, Kazuhiko., Sato, Motonobu., Nishiya, Takayoshi., Takamatsu, Kazuhiko., Arakawa, Noriaki., Izumi, Takashi., Ohno, Yasuo., Saito, Yoshiro., Takikawa, Hajime.
- 雑誌名
- Metabolites
- DOI
- 10.3390/metabo10090355
- PMID
- 32878279
- Online published
- 2020 Aug 31
-
Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines
- 著者
- Katayama, Katsushi., Ishii, Ken., Tsuda, Eisuke., Yotsumoto, Keiichi., Hiramoto, Kumiko., Suzuki, Makoto., Yasumatsu, Isao., Igarashi, Wataru., Torihata, Munefumi., Ishiyama, Takashi., Katagiri, Takahiro.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2020.127475.
- PMID
- 32781218
- Online published
- 2020 Aug 20
-
Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells
- 著者
- Noguchi, Shingo., Ishikawa, Hirokazu., Wakita, Kenichi., Matsuda, Fumio., Shimizu, Hiroshi.
- 雑誌名
- Scientific Reports
- DOI
- 10.1038/s41598-020-70000-6
- PMID
- 32747645
- Online published
- 2020 Aug 03
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Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine
- 著者
- Tomono, Takumi., Yagi, Haruya., Ukawa, Masami., Ishizaki, Seiya., Miwa, Takahiro., Nonomura, Mao., Igi, Ryoji., Kumagai, Hironori., Miyata, Kohei., Tobita, Etsuo., Kobayashi, Hideo., Sakuma, Shinji.
- 雑誌名
- Eur J Pharm Biopharm
- DOI
- 10.1016/j.ejpb.2020.07.003
- PMID
- 32681963
- Online published
- 2020 Jul 15
-
Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation
- 著者
- Aki, Anri., Tanaka, Kento., Nagaoka, Nobumi., Kimura, Takako., Baba, Daichi., Onodera, Yoshikuni., Wada, Teiji., Maeda, Hiroaki., Nakanishi, Toshiyuki., Agatsuma, Toshinori., Komai, Tomoaki.
- 雑誌名
- FASEB Bioadv
- DOI
- 10.1096/fba.2020-00008
- PMID
- 32821879
- Online published
- 2020 Jul 08
-
U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
- 著者
- Papadopoulos, Kyriakos P., Borazanci, Erkut., Shaw, Alice T., Katayama, Ryohei., Shimizu, Yuki., Zhu, Viola W., Sun, Thomas Yang., Wakelee, Heather A., Madison, Russell., Schrock, Alexa B., Senaldi, Giorgio., Nakao, Naoki., Hanzawa, Hiroyuki., Tachibana, Masaya., Isoyama, Takeshi., Nakamaru, Kenji., Deng, Chenhui., Li, Meijing., Fan, Frank., Zhao, Qinying., Gao, Yanfei., Seto , Takashi., Jänne, Pasi A., Ou, Sai-Hong Ignatius.
- 雑誌名
- Clin Cancer Res
- 巻
- 26
- ページ
- 4785-4794
- 年
- 2020
- DOI
- 10.1158/1078-0432.CCR-20-1630
- PMID
- Online published
- 2020 Jun 26
-
Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment
- 著者
- Brinkwirth, Nina., Takasuna, Kiyoshi., Doi, Masafumi., Becker, Nadine., Obergrussberger, Alison., Friis, Søren., Furukawa, Hatsue., Hasegawa, Yuka., Oka, Takayuki., Ohtsuki, Atsushi., Fertig, Niels., Stoelzle-Feix, Sonja.
- 雑誌名
- J Pharmacol Toxicol Methods
- DOI
- 10.1016/j.vascn.2020.106884
- PMID
- 32565325
- Online published
- 2020 Jun 18
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The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina
- 著者
- Sayama, Ayako., Okado, Keiko., Yamaguchi, Mayu., Samata, Naozumi., Imaoka, Masako., Kai, Kiyonori., Mori, Kazuhiko.
- 雑誌名
- Toxicol Pathol
- DOI
- 10.1177/0192623320931415
- PMID
- 32538308
- Online published
- 2020 Jun 15
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A Metabolic Pathway for Bile Acid Dehydroxylation by the Gut Microbiome
- 著者
- Funabashi, Masanori., Grove, Tyler L., Wang, Min., Varma, Yug., McFadden, Molly E., Brown, Laura C., Guo, Chunjun., Higginbottom, Steven., Almo, Steven C., Fischbach, Michael A.
- 雑誌名
- Nature
- DOI
- 10.1038/s41586-020-2396-4
- PMID
- 32555455
- Online published
- 2020 Jun 17
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Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor
- 著者
- Shinozuka, Tsuyoshi., Kobayashi, Hiroyuki., Suzuki, Sayaka., Tanaka, Kyosuke., Karanjule, Narayan., Hayashi, Noriyuki., Tsuda, Toshifumi., Tokumaru, Eri., Inoue, Masahiro., Ueda, Kiyono., Kimoto, Hiroko., Domon, Yuki., Takahashi, Sakiko., Kubota, Kazufumi., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Sakakura, Tomoko., Takasuna, Kiyoshi., Abe, Yasuyuki., Watanabe, Toshiyuki., Kitano, Yutaka.
- 雑誌名
- J Med Chem
- 巻
- 63
- ページ
- 10204-10220
- 年
- 2020
- DOI
- 10.1021/acs.jmedchem.0c00259
- PMID
- 32392056
- Online published
- 2020 May 26
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Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin With a Potential Implication of ECG Abnormalities of DMD Patients
- 著者
- Rani, Abdul Qawee Mahyoob., Yamamoto, Tetsushi., Kawaguchi, Tatsuya., Maeta, Kazuhiro., Awano, Hiroyuki., Nishio, Hisahide., Matsuo, Masafumi.
- 雑誌名
- Int J Mol Sci
- DOI
- 10.3390/ijms21103555
- PMID
- 32443516
- Online published
- 2020 May 18
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Revisiting Biomolecular NMR Spectroscopy for Promoting Small-Molecule Drug Discovery
- 著者
- Hanzawa, Hiroyuki., Shimada, Takashi., Takahashi, Mizuki., Takahashi, Hideo.
- 雑誌名
- J Biomol NMR
- DOI
- 10.1007/s10858-020-00314-0
- PMID
- 32306215
- Online published
- 2020 Apr 18
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Meta-analyses on Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Triple-Negative Breast Cancer
- 著者
- Hirai, Takehiro., Nemoto, Asuka., Ito, Yoshinor., Matsuura, Masaaki.
- 雑誌名
- Breast Cancer Res Treat
- DOI
- 10.1007/s10549-020-05615-4
- PMID
- 32246379
- Online published
- 2020 Apr 03
-
Discovery of Novel Pyrrole Derivatives as Potent Agonists for the Niacin Receptor GPR109A
- 著者
- Miyazawa, Yuriko., Yamaguchi, Takahiro., Yamaguchi, Mitsuhiro., Tago, Keiko., Tamura, Akihiro., Sugiyama, Daisuke., Aburatani, Takahide., Nishizawa, Tomohiro., Kurikawa, Nobuya., Kono, Keita.
- 雑誌名
- Bioorg Med Chem Lett
- DOI
- 10.1016/j.bmcl.2020.127105
- PMID
- 32199732
- Online published
- 2020 Mar 10
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Crystal Structure of the Mineralocorticoid Receptor Ligand-Binding Domain in Complex With a Potent and Selective Nonsteroidal Blocker, Esaxerenone (CS-3150)
- 著者
- Takahashi, Mizuki., Ubukata, Osamu., Homma, Tsuyoshi., Asoh, Yusuke., Honzumi Masatoshi., Hayashi, Noriyuki., Saito, Keiji., Tsuruoka, Hiroyuki., Aoki, Kazumasa., Hanzawa, Hiroyuki.
- 雑誌名
- FEBS Lett
- 巻
- 594
- ページ
- 1615-1623
- 年
- 2020
- DOI
- 10.1002/1873-3468.13746
- PMID
- 31991486
- Online published
- 2020 Feb 19
-
The Urotensin II Receptor Antagonist DS37001789 Ameliorates Mortality in Pressure-Overload Mice With Heart Failure
- 著者
- Nishi, Mina., Tagawa, Hideki., Ueno, Masumi., Marumoto, Shinji., Nagayama, Takahiro.
- 雑誌名
- Heliyon
- DOI
- 10.1016/j.heliyon.2020.e03352
- PMID
- 32055741
- Online published
- 2020 Feb 03
-
Discovery of a Novel Class of State-Dependent Na V 1.7 Inhibitors for the Treatment of Neuropathic Pain
- 著者
- Tanaka, Kyosuke., Kobayashi, Hiroyuki., Suzuki, Sayaka., Shibuya, Satoshi., Kimoto, Hiroko., Domon, Yuki., Kubota, Kazufumi., Kitano, Yutaka., Yokoyama, Tomihisa., Shimizugawa, Akiko., Koishi, Ryuta., Fujiwara, Chie., Asano, Daigo., Shinozuka Tsuyoshi.
- 雑誌名
- Chem Pharm Bull (Tokyo)
- DOI
- 10.1248/cpb.c20-00126
- PMID
- 32612000
- Online published
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An in silico approach to determine challenges in the bioavailability of ciprofloxacin, a poorly soluble weak base with borderline solubility and permeability characteristics
- 著者
- Hansmann, Simone., Miyaji, Yoshihiro., Dressman, Jennifer.
- 雑誌名
- Eur J Pharm Biopharm
- DOI
- 10.1016/j.ejpb.2017.10.019
- PMID
- 29111469
- Online published
- 2017 Oct 27
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Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions
- 著者
- Kawakami, Kohsaku., Suzuki, Kyosuke., Fukiage, Masafumi., Matsuda, Maki., Nishida, Yohei., Oikawa,
Michinori., Fujita, Takuya.
- 雑誌名
- Journal of Drug Delivery Science and Technology
- DOI
- 10.1016/j.jddst.2019.101172
- PMID
- Online published
- 2019 Jul 22
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Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
- 著者
- Ohura, Kayoko., Igawa, Yoshiyuki., Tanaka, Maori., Matsumoto, Kana., Kasahara, Akiko., Wada, Naoya., Kubota, Kazuishi., Uno, Yasuhiro., Imai, Teruko.
- 雑誌名
- Drug metabolism and disposition: the biological fate of chemicals
- DOI
- 10.1124/dmd.119.089011
- PMID
- 31836607
- Online published
- 2020 Jan 30
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Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
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- Kaji, Tomohiro., Koga, Hiroshi., Kuroha, Mutsumi., Akimoto, Toshihiko., Hayata, Kenji.
- 雑誌名
- Scientific Reports
- DOI
- 10.1038/s41598-020-59966-5
- PMID
- 32080280
- Online published
- 2020 Feb 20
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A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model
- 著者
- Machida, Yukino., Nakagawa, Makoto., Matsunaga, Hironori., Yamaguchi, Masayuki., Ogawara, Yoko., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Hattori, Ayuna., Itoh, Masao., Seki, Takahiko., Nishiya, Yumi., Nakamura, Koichi., Suzuki, Kanae., Imaoka, Tomoki., Baba, Daichi., Suzuki, Makoto., Sampetrean, Oltea., Saya, Hideyuki., Ichimura, Koichi., Kitabayashi, Issay.
- 雑誌名
- Molecular cancer therapeutics
- DOI
- 10.1158/1535-7163.MCT-18-1349
- PMID
- 31727689
- Online published
- 2019 Nov 14
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Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers
- 著者
- Duisters, Kevin., Ogino, Shinji., Andou, Tomohiro., Ito, Kazumi., Akabane, Takafumi., Harms, Amy., Moerland, Matthijs., Hashimoto, Yuka., Ando, Ayumi., Ohtsu, Yoshiaki., Wada, Naoya., Yukinaga, Hideo., Meulman, Jacqueline., Kobayashi, Hiroyuki., Kobayashi, Nobuhiro., Suzumura, Kenichi., Hankemeier, Thomas.
- 雑誌名
- Clinical pharmacology and therapeutics
- DOI
- 10.1002/cpt.1606
- PMID
- 31400148
- Online published
- 2019 Aug 10
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Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition
- 著者
- Nishiya, Yumi., Suzuki, Eiko., Ishizuka, Tomoko., Kazui, Miho., Sakurai, Hidetaka., Nakai, Daisuke.
- 雑誌名
- Drug metabolism and pharmacokinetics
- DOI
- 10.1016/j.dmpk.2019.11.001
- PMID
- 31926835
- Online published
- 2019 Dec 24
-
Preclinical Development of U3-1784, a Novel FGFR4 Antibody against Cancer, and Avoidance of Its On-target Toxicity
- 著者
- Bartz, Rene., Fukuchi, Keisuke., Ohtsuka, Toshiaki., Lange, Tanja., Gruner, Katrin., Watanabe, Ichiro., Hayashi, Shinko., Oda, Yoko., Kawaida, Reimi., Komori, Hironobu., Kashimoto, Yoshinori., Wirtz, Peter., Mayer, Jan Peter A.., Redondo-Muller, Mauricio., Saito, Shuntaro., Takahashi, Mizuki., Hanzawa, Hiroyuki., Imai, Emi., Martinez, Alberto., Hanai, Masaharu., Haussinger, Dieter., Chapman, Roger W.., Agatsuma, Toshinori., Bange, Johannes., Abraham, Reimar.
- 雑誌名
- Molecular Cancer Therapeutics
- 巻
- 18
- ページ
- 1832-1843
- 年
- 2019
- DOI
- 10.1158/1535-7163.MCT-18-0048
- PMID
- Online published
- 2019 Jul 26
-
Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
- 著者
- Kawai, Junya., Toki, Tadashi., Ota, Masahiro., Inoue, Hidekazu., Takata, Yoshimi., Asahi, Takashi., Suzuki, Makoto., Shimada, Takashi., Ono, Kaori., Suzuki, Kanae., Takaishi, Sachiko., Ohki, Hitoshi., Matsui, Satoshi., Tsutsumi, Shinji., Hirota, Yasuhide., Nakayama, Kiyoshi.
- 雑誌名
- Journal of medicinal chemistry
- 巻
- 62
- ページ
- 10204-10220
- 年
- 2019
- DOI
- 10.1021/acs.jmedchem.9b01113
- PMID
- 31638799
- Online published
- 2019 Oct 22
-
Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold
- 著者
- Kawai, Junya., Ota, Masahiro., Ohki, Hitoshi., Toki, Tadashi., Suzuki, Makoto., Shimada, Takashi., Matsui, Satoshi., Inoue, Hidekazu., Sugihara, Chika., Matsuhashi, Norikazu., Matsui, Yumi., Takaishi, Sachiko., Nakayama, Kiyoshi.
- 雑誌名
- ACS Medicinal Chemistry Letters
- DOI
- 10.1021/acsmedchemlett.9b00069
- PMID
- Online published
- 2019 May 24
-
Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity
- 著者
- Taniguchi, Toru., Inagaki, Hiroaki., Baba, Daichi., Yasumatsu, Isao., Toyota, Akiko., Kaneta, Yasuyuki., Kiga, Masaki., Iimura, Shin., Odagiri, Takashi., Shibata, Yoshihiro., Ueda, Kiyono., Seo, Maki., Shimizu, Hiroki., Imaoka, Tomoki., Nakayama, Kiyoshi.
- 雑誌名
- ACS Medicinal Chemistry Letters
- DOI
- 10.1177/0192623318809062
- PMID
- Online published
- 2019 Mar 15
-
Functional and Morphological Characteristics of Pancreatic Islet Lesions Induced by Quinolone Antimicrobial Agent Gatifloxacin in Rats
- 著者
- Yabe, Koichi., Yamamoto, Yuka., Suzuki, Takami., Takada, Sanae., Mori, Kazuhiko.
- 雑誌名
- Toxicologic pathology
- DOI
- 10.1177/0192623318809062
- PMID
- 30407147
- Online published
- 2018 Nov 08
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Practical one-step glucuronidation via biotransformation
- 著者
- Ohnuki, Takashi., Ejiri, Masahiko., Kizuka, Masaaki., Fujiwara, Mie., Nishi, Takahide.
- 雑誌名
- Bioorganic and Medicinal Chemistry Letters
- DOI
- 2019
- PMID
- Online published
- 2018 Nov 28
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Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones
- 著者
- Komoriya, Satoshi., Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Miyauchi, Rie., Yoshida, Ken-Ichi., Kitamura, Takahiro., Takahashi, Hisashi.
- 雑誌名
- Chemical & pharmaceutical bulletin
- DOI
- 10.1248/cpb.c18-00671
- PMID
- 30606950
- Online published
- 2019 Jan 01
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Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma
- 著者
- Nakagawa, Makoto., Fujita, Shuhei., Katsumoto, Takuo., Yamagata, Kazutsune., Ogawara, Yoko., Hattori, Ayuna., Kagiyama, Yuki., Honma, Daisuke., Araki, Kazushi., Inoue, Tatsuya., Kato, Ayako., Inaki, Koichiro., Wada, Chisa., Ono, Yoshimasa., Yamamoto, Masahide., Miura, Osamu., Nakashima, Yasuharu., Kitabayashi, Issay.
- 雑誌名
- Cancer Science
- DOI
- 10.1111/cas.13840
- PMID
- 30343511
- Online published
- 2018 Nov 16
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Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches
- 著者
- Kubota, Kazuishi., Funabashi, Masanori., Ogura, Yuji.
- 雑誌名
- Biochimica et Biophysica Acta - Proteins and Proteomics
- DOI
- 10.1016/j.bbapap.2018.08.002
- PMID
- 30392561
- Online published
-
Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology
- 著者
- Ohki, Yu., Sakurai, Hidetaka., Hoshino, Madoka., Terashima, Hideki., Shimizu, Hiroki., Ishikawa, Tomio., Ogiyama, Tomoko., Muramatsu, Yasunori., Nakanishi, Toshiyuki., Miyazaki, Shojiro., Tsuruoka, Hiroyuki., Kobayashi, Hideki., Kubota, Kazuishi.
- 雑誌名
- Cell chemical biology
- 巻
- 26
- ページ
- 137-143.e8
- 年
- 2019
- DOI
- 10.1016/j.chembiol.2018.10.012
- PMID
- 30449674
- Online published
- 2018 Nov 15
-
Identification of the shortest splice variant of Dp71, together with five known variants, in glioblastoma cells
- 著者
- Rani, Abdul Qawee Mahyoob., Farea, Manal., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
- 雑誌名
- Biochemical and Biophysical Research Communications
- DOI
- 10.1016/j.bbrc.2018.11.168
- PMID
- Online published
- 2018 Dec 05
-
Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
- 著者
- Terashima, Hideki., Aonuma, Misato., Tsuchida, Hiroshi., Sugimoto, Kotaro., Yokoyama, Mika., Kato, Mikio.
- 雑誌名
- Pulmonary Pharmacology & Therapeutics
- DOI
- 10.1016/j.pupt.2018.11.005
- PMID
- 30448291
- Online published
- 2018 Nov 15
-
Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930
- 著者
- Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Matsui, Yumi., Wakimoto, Satoko., Ogata, Tsuneaki., Araki, Kazushi., Sawamura, Ryoko., Watanabe, Nobuaki., Mori, Makoto., Tanaka, Jun.
- 雑誌名
- ACS Medicinal Chemistry Letters
- DOI
- 10.1021/acsmedchemlett.8b00645
- PMID
- Online published
- 2019 Feb 26
-
Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation
- 著者
- Kishino, Yuki., Hasegawa, Tomoko., Kato, Ayako., Nishiya, Yumi., Rozhnal, Veronika., Watanabe, Kyoko., Takasaki, Wataru., Yamoto, Takashi., Mori, Kazuhiko.
- 雑誌名
- Mutation Research - Genetic Toxicology and Environmental Mutagenesis
- DOI
- 10.1016/j.mrgentox.2018.11.016
- PMID
- Online published
- 2018 Dec 05
-
Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization
- 著者
- Fujita, Yoko., Kagoshima, Yoshiko., Masuda, Takeshi., Kizuka, Masaaki., Ogawa, Yasumasa., Endo, Shuichi., Nishigoori, Hideaki., Saito, Kazuko., Takasugi, Kunio., Miura, Masami., Murakami, Ryo., Muramatsu, Yasunori., Tokumitsu, Akane., Koga, Tetsufumi., Iizuka, Mayumi., Aoyagi, Azusa., Suzuki, Toshihiro., Suzuki, Takashi., Suzuki, Yasuhiro., Ishida, Osamu., Nakahira, Toru., Miyakoshi, Shunichi., Konosu, Toshiyuki., Takatsu, Toshio.
- 雑誌名
- The Journal of antibiotics
- DOI
- 10.1038/s41429-019-0215-7
- PMID
- 31413314
- Online published
- 2019 Aug 14
-
Schwann cell-specific Dp116 is expressed in glioblastoma cells, revealing two novel DMD gene splicing patterns
- 著者
- Mahyoob Rani, Abdul Qawee., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
- 雑誌名
- Biochemistry and biophysics reports
- DOI
- 10.1016/j.bbrep.2019.100703
- PMID
- 31737793
- Online published
- 2019 Nov 10