-
Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
- 著者
- Sawamura, Ryoko., Sakurai, Hidetaka., Wada, Naoya., Nishiya, Yumi., Honda, Tomoyo., Kazui, Miho., Kurihara, Atsushi., Shinagawa, Akira., Izumi, Takashi.
- 雑誌名
- Biopharmaceutics and Drug Disposition
- DOI
- 10.1002/bdd.1945
- PMID
- Online published
- 2015 Apr 21
-
Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558
- 著者
- Takano, Rieko., Yoshida, Masao., Inoue, Masahiro., Honda, Takeshi., Nakashima, Ryutaro., Matsumoto, Koji., Yano, Tatsuya., Ogata, Tsuneaki., Watanabe, Nobuaki., Hirouchi, Masakazu., Kimura, Takako., Toda, Narihiro.
- 雑誌名
- Bioorganic and Medicinal Chemistry
- 巻
- 23
- ページ
- 5546-5565
- 年
- 2015
- DOI
- 10.1016/j.bmc.2015.07.028
- PMID
- Online published
- 2015 Jul 23
-
Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists
- 著者
- Matsui, Yumi., Yamaguchi, Takahiro., Yamazaki, Takanori., Yoshida, Masayuki., Arai, Masami., Terasaka, Naoki., Honzumi, Shoko., Wakabayashi, Kenji., Hayashi, Shinko., Nakai, Daisuke., Hanzawa, Hiroyuki., Tamaki, Kazuhiko.
- 雑誌名
- Bioorganic and Medicinal Chemistry Letters
- 巻
- 25
- ページ
- 3914-3920
- 年
- 2015
- DOI
- 10.1016/j.bmcl.2015.07.047
- PMID
- Online published
- 2015 Jul 23
-
The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE
- 著者
- Cai, Wenlong., Goswami, Anwesha., Yang, Zhaoyong., Liu, Xiaodong., Green, Keith D., Barnard-Britson, Sandra., Baba, Satoshi., Funabashi, Masanori., Nonaka, Koichi., Sunkara, Manjula., Morris, Andrew J., Spork, Anatol P., Ducho, Christian., Garneau-Tsodikova, Sylvie., Thorson, Jon S., Van Lanen, Steven G.
- 雑誌名
- The Journal of biological chemistry
- 巻
- 290
- ページ
- 13710-24
- 年
- 2015
- DOI
- 10.1074/jbc.M115.646414
- PMID
- 25855790
- Online published
- 2015 Apr 08
-
Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917
- 著者
- Kubota, Kazuishi., Inaba, Shin ichi., Nakano, Rika., Watanabe, Mihoko., Sakurai, Hidetaka., Fukushima, Yumiko., Ichikawa, Kimihisa., Takahashi, Tohru., Izumi, Takashi., Shinagawa, Akira.
- 雑誌名
- Pharmacology Research and Perspectives
- 巻
- 3
- ページ
- e00138 19pages
- 年
- 2015
- DOI
- 10.1002/prp2.138
- PMID
- Online published
- 2015 May 04
-
Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys
- 著者
- Iwasaki, Masaru., Koyanagi, Satoru., Suzuki, Norio., Katamune, Chiharu., Matsunaga, Naoya., Watanabe, Nobuaki., Takahashi, Masayuki., Izumi, Takashi., Ohdo, Shigehiro.
- 雑誌名
- Molecular pharmacology
- DOI
- 10.1124/mol.114.096735
- PMID
- 25901027
- Online published
- 2015 May 18
-
Discovery of DS-1558: A potent and orally bioavailable GPR40 agonist
- 著者
- Takano, Rieko., Yoshida, Masao., Inoue, Masahiro., Honda, Takeshi., Nakashima, Ryutaro., Matsumoto, Koji., Yano, Tatsuya., Ogata, Tsuneaki., Watanabe, Nobuaki., Hirouchi, Masakazu., Yoneyama, Tomoko., Ito, Shuichiro., Toda, Narihiro.
- 雑誌名
- ACS Medicinal Chemistry Letters
- DOI
- 10.1021/ml500391n
- PMID
- 2015
- Online published
- 2015 Mar 12
-
Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach
- 著者
- Matsufuji, Tetsuyoshi., Shimada, Kousei., Kobayashi, Shozo., Ichikawa, Masanori., Kawamura, Asuka., Fujimoto, Teppei., Arita, Tsuyoshi., Hara, Takashi., Konishi, Masahiro., Abe-Ohya, Rie., Izumi, Masanori., Sogawa, Yoshitaka., Nagai, Yoko., Yoshida, Kazuhiro., Abe, Yasuyuki., Kimura, Takako., Takahashi, Hisashi.
- 雑誌名
- Bioorganic & medicinal chemistry
- DOI
- 10.1016/j.bmc.2014.11.018
- PMID
- 25497965
- Online published
- 2014 Nov 21
-
Biosynthesis of nectrisine in Thelonectria discophora SANK 18292
- 著者
- Miyauchi, Ryuki., Takatsu, Toshio., Suzuki, Tetsuya., Ono, Yasunori., Shiba, Yoichiro.
- 雑誌名
- Phytochemistry
- DOI
- 10.1016/j.phytochem.2015.03.011
- PMID
- 25865736
- Online published
- 2015 Apr 09
-
Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist
- 著者
- Arai, Kiyoshi., Homma, Tsuyoshi., Morikawa, Yuka., Ubukata, Naoko., Tsuruoka, Hiyoyuki., Aoki, Kazumasa., Ishikawa, Hirokazu., Mizuno, Makoto., Sada, Toshio.
- 雑誌名
- European journal of pharmacology
- DOI
- 10.1016/j.ejphar.2015.06.015
- PMID
- 26073023
- Online published
- 2015 Jun 11
-
Clinical safety, tolerability, pharmacokinetics and pharmacodynamics of the novel factor xa inhibitor DY-807f in healthy volunteers
- 著者
- Ogata, Koichiro., Shimizu, Takako., Masumoto, Hiroshi., Oguma, Toshihiro., Sugiyama, Nobutoshi., Kunitada, Satoshi.
- 雑誌名
- Thrombosis Research
- DOI
- 10.1016/j.thromres.2014.12.028
- PMID
- Online published
- 2015 Jan 04
-
Pharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys
- 著者
- Inaba, Shin Ichi., Ikeda, Tomoko., Goto, Maki., Tanaka, Hisako., Takahashi, Makoto., Iwabuchi, Haruo., Izumi, Takashi.
- 雑誌名
- Xenobiotica
- 巻
- 45
- ページ
- 1063-1080
- 年
- 2015
- DOI
- 10.3109/00498254.2015.1039097
- PMID
- Online published
- 2015 Jun 18
-
Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists
- 著者
- Abe-Ohya, Rie., Ishikawa, Tomio., Shiozawa, Hideyuki., Suda, Koji., Nara, Futoshi.
- 雑誌名
- Journal of Receptors and Signal Transduction
- DOI
- 10.3109/10799893.2015.1015736
- PMID
- Online published
- 2015 Jun 08
-
SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors
- 著者
- Malik, Shivani., Villanova, Lidia., Tanaka, Shinji., Aonuma, Misato., Roy, Nilotpal., Berber, Elisabeth., Pollack, Jonathan R., Michishita-Kioi, Eriko., Chua, Katrin F.
- 雑誌名
- Scientific reports
- DOI
- 10.1038/srep09841
- PMID
- 25923013
- Online published
- 2015 Apr 29
-
Structure of N-myristoyltransferase from Aspergillus fumigatus
- 著者
- Shimada, Takashi., Suzuki, Makoto., Katakura, Shinichi.
- 雑誌名
- Acta Crystallographica Section D: Biological Crystallography
- DOI
- 10.1107/S1399004715000401
- PMID
- Online published
- 2015 Mar 26
-
Suppression of Problematic Compound Oligomerization by Cosolubilization of Nondetergent Sulfobetaines
- 著者
- Mizukoshi, Yumiko., Takeuchi, Koh., Arutaki, Misa., Takizawa, Takeshi., Hanzawa, Hiroyuki., Takahashi, Hideo., Shimada, Ichio.
- 雑誌名
- ChemMedChem
- DOI
- 10.1002/cmdc.201500057
- PMID
- 25760302
- Online published
- 2015 Mar 11
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