主な投稿論文

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Achievements主な投稿論文

  • Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
    著者
    Sawamura, Ryoko., Sakurai, Hidetaka., Wada, Naoya., Nishiya, Yumi., Honda, Tomoyo., Kazui, Miho., Kurihara, Atsushi., Shinagawa, Akira., Izumi, Takashi.
    雑誌名
    Biopharmaceutics and Drug Disposition
    36
    ページ
    352-363
    2015
    DOI
    10.1002/bdd.1945
    PMID
    Online published
    2015 Apr 21
  • Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558
    著者
    Takano, Rieko., Yoshida, Masao., Inoue, Masahiro., Honda, Takeshi., Nakashima, Ryutaro., Matsumoto, Koji., Yano, Tatsuya., Ogata, Tsuneaki., Watanabe, Nobuaki., Hirouchi, Masakazu., Kimura, Takako., Toda, Narihiro.
    雑誌名
    Bioorganic and Medicinal Chemistry
    23
    ページ
    5546-5565
    2015
    DOI
    10.1016/j.bmc.2015.07.028
    PMID
    Online published
    2015 Jul 23
  • Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists
    著者
    Matsui, Yumi., Yamaguchi, Takahiro., Yamazaki, Takanori., Yoshida, Masayuki., Arai, Masami., Terasaka, Naoki., Honzumi, Shoko., Wakabayashi, Kenji., Hayashi, Shinko., Nakai, Daisuke., Hanzawa, Hiroyuki., Tamaki, Kazuhiko.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    25
    ページ
    3914-3920
    2015
    DOI
    10.1016/j.bmcl.2015.07.047
    PMID
    Online published
    2015 Jul 23
  • The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE
    著者
    Cai, Wenlong., Goswami, Anwesha., Yang, Zhaoyong., Liu, Xiaodong., Green, Keith D., Barnard-Britson, Sandra., Baba, Satoshi., Funabashi, Masanori., Nonaka, Koichi., Sunkara, Manjula., Morris, Andrew J., Spork, Anatol P., Ducho, Christian., Garneau-Tsodikova, Sylvie., Thorson, Jon S., Van Lanen, Steven G.
    雑誌名
    The Journal of biological chemistry
    290
    ページ
    13710-24
    2015
    DOI
    10.1074/jbc.M115.646414
    PMID
    25855790
    Online published
    2015 Apr 08
  • Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917
    著者
    Kubota, Kazuishi., Inaba, Shin ichi., Nakano, Rika., Watanabe, Mihoko., Sakurai, Hidetaka., Fukushima, Yumiko., Ichikawa, Kimihisa., Takahashi, Tohru., Izumi, Takashi., Shinagawa, Akira.
    雑誌名
    Pharmacology Research and Perspectives
    3
    ページ
    e00138 19pages
    2015
    DOI
    10.1002/prp2.138
    PMID
    Online published
    2015 May 04
  • Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys
    著者
    Iwasaki, Masaru., Koyanagi, Satoru., Suzuki, Norio., Katamune, Chiharu., Matsunaga, Naoya., Watanabe, Nobuaki., Takahashi, Masayuki., Izumi, Takashi., Ohdo, Shigehiro.
    雑誌名
    Molecular pharmacology
    88
    ページ
    29-37
    2015
    DOI
    10.1124/mol.114.096735
    PMID
    25901027
    Online published
    2015 May 18
  • Discovery of DS-1558: A potent and orally bioavailable GPR40 agonist
    著者
    Takano, Rieko., Yoshida, Masao., Inoue, Masahiro., Honda, Takeshi., Nakashima, Ryutaro., Matsumoto, Koji., Yano, Tatsuya., Ogata, Tsuneaki., Watanabe, Nobuaki., Hirouchi, Masakazu., Yoneyama, Tomoko., Ito, Shuichiro., Toda, Narihiro.
    雑誌名
    ACS Medicinal Chemistry Letters
    6
    ページ
    266-270
    2015
    DOI
    10.1021/ml500391n
    PMID
    2015
    Online published
    2015 Mar 12
  • Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach
    著者
    Matsufuji, Tetsuyoshi., Shimada, Kousei., Kobayashi, Shozo., Ichikawa, Masanori., Kawamura, Asuka., Fujimoto, Teppei., Arita, Tsuyoshi., Hara, Takashi., Konishi, Masahiro., Abe-Ohya, Rie., Izumi, Masanori., Sogawa, Yoshitaka., Nagai, Yoko., Yoshida, Kazuhiro., Abe, Yasuyuki., Kimura, Takako., Takahashi, Hisashi.
    雑誌名
    Bioorganic & medicinal chemistry
    23
    ページ
    89-104
    2015
    DOI
    10.1016/j.bmc.2014.11.018
    PMID
    25497965
    Online published
    2014 Nov 21
  • Biosynthesis of nectrisine in Thelonectria discophora SANK 18292
    著者
    Miyauchi, Ryuki., Takatsu, Toshio., Suzuki, Tetsuya., Ono, Yasunori., Shiba, Yoichiro.
    雑誌名
    Phytochemistry
    116
    ページ
    87-93
    2015
    DOI
    10.1016/j.phytochem.2015.03.011
    PMID
    25865736
    Online published
    2015 Apr 09
  • Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist
    著者
    Arai, Kiyoshi., Homma, Tsuyoshi., Morikawa, Yuka., Ubukata, Naoko., Tsuruoka, Hiyoyuki., Aoki, Kazumasa., Ishikawa, Hirokazu., Mizuno, Makoto., Sada, Toshio.
    雑誌名
    European journal of pharmacology
    761
    ページ
    226-34
    2015
    DOI
    10.1016/j.ejphar.2015.06.015
    PMID
    26073023
    Online published
    2015 Jun 11
  • Clinical safety, tolerability, pharmacokinetics and pharmacodynamics of the novel factor xa inhibitor DY-807f in healthy volunteers
    著者
    Ogata, Koichiro., Shimizu, Takako., Masumoto, Hiroshi., Oguma, Toshihiro., Sugiyama, Nobutoshi., Kunitada, Satoshi.
    雑誌名
    Thrombosis Research
    135
    ページ
    594-601
    2015
    DOI
    10.1016/j.thromres.2014.12.028
    PMID
    Online published
    2015 Jan 04
  • Pharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys
    著者
    Inaba, Shin Ichi., Ikeda, Tomoko., Goto, Maki., Tanaka, Hisako., Takahashi, Makoto., Iwabuchi, Haruo., Izumi, Takashi.
    雑誌名
    Xenobiotica
    45
    ページ
    1063-1080
    2015
    DOI
    10.3109/00498254.2015.1039097
    PMID
    Online published
    2015 Jun 18
  • Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists
    著者
    Abe-Ohya, Rie., Ishikawa, Tomio., Shiozawa, Hideyuki., Suda, Koji., Nara, Futoshi.
    雑誌名
    Journal of Receptors and Signal Transduction
    35
    ページ
    485-492
    2015
    DOI
    10.3109/10799893.2015.1015736
    PMID
    Online published
    2015 Jun 08
  • SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors
    著者
    Malik, Shivani., Villanova, Lidia., Tanaka, Shinji., Aonuma, Misato., Roy, Nilotpal., Berber, Elisabeth., Pollack, Jonathan R., Michishita-Kioi, Eriko., Chua, Katrin F.
    雑誌名
    Scientific reports
    5
    ページ
    9841
    2015
    DOI
    10.1038/srep09841
    PMID
    25923013
    Online published
    2015 Apr 29
  • Structure of N-myristoyltransferase from Aspergillus fumigatus
    著者
    Shimada, Takashi., Suzuki, Makoto., Katakura, Shinichi.
    雑誌名
    Acta Crystallographica Section D: Biological Crystallography
    71
    ページ
    754-761
    2015
    DOI
    10.1107/S1399004715000401
    PMID
    Online published
    2015 Mar 26
  • Suppression of Problematic Compound Oligomerization by Cosolubilization of Nondetergent Sulfobetaines
    著者
    Mizukoshi, Yumiko., Takeuchi, Koh., Arutaki, Misa., Takizawa, Takeshi., Hanzawa, Hiroyuki., Takahashi, Hideo., Shimada, Ichio.
    雑誌名
    ChemMedChem
    10
    ページ
    736-741
    2015
    DOI
    10.1002/cmdc.201500057
    PMID
    25760302
    Online published
    2015 Mar 11