主な投稿論文

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  • DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
    著者
    Ogitani, Yusuke., Aida, Tetsuo., Hagihara, Katsunobu., Yamaguchi, Junko., Ishii, Chiaki., Harada, Naoya., Soma, Masako., Okamoto, Hiromi., Oitate, Masataka., Arakawa, Shingo., Hirai, Takehiro., Atsumi, Ryo., Nakada, Takashi, Hayakawa., Ichiro., Abe, Yuki., Agatsuma, Toshinori.
    雑誌名
    Clin Cancer Res
    巻
    22
    ページ
    5097-5108
    年
    2016
    DOI
    10.1158/1078-0432.CCR-15-2822
    PMID
    27026201
    Online published
    2016 Mar 29
  • Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents
    著者
    Watanabe, Akiko., Takakusa, Hideo., Kimura, Takako., Inoue, Shin-Ichi., Kusuhara, Hiroyuki., Ando, Osamu.
    雑誌名
    Drug metabolism and disposition: the biological fate of chemicals
    巻
    44
    ページ
    1608-16
    年
    2016
    DOI
    10.1124/dmd.116.071654
    PMID
    27469000
    Online published
    2016 Aug 29
  • Studies on novel HIF activators, A-503451s.I. Producing organism, fermentation, isolation and structural elucidation
    著者
    Hirota-Takahata, Yuki., Kobayashi, Hideki., Kizuka, Masaaki., Ohyama, Takao., Kitamura-Miyazaki, Michiko., Suzuki, Yasuhiro., Fujiwara, Mie., Nakajima, Mutsuo., Ando, Osamu.
    雑誌名
    Journal of Antibiotics
    巻
    69
    ページ
    747-753
    年
    2016
    DOI
    10.1038/ja.2016.17
    PMID
    Online published
    2016 Mar 09
  • Studies on novel HIF activators, A-503451sII: Biological activities of A-503451A
    著者
    Kobayashi, Hideki., Ohyama, Takao., Kitamura-Miyazaki, Michiko., Hirota-Takahata, Yuki., Ando, Osamu.
    雑誌名
    Journal of Antibiotics
    巻
    69
    ページ
    754-758
    年
    2016
    DOI
    10.1038/ja.2016.20
    PMID
    Online published
    2016 Mar 09
  • Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State
    著者
    Mizukoshi, Yumiko., Takeuchi, Koh., Arutaki, Misa., Tokunaga, Yuji., Takizawa, Takeshi., Hanzawa, Hiroyuki., Shimada, Ichio.
    雑誌名
    Angewandte Chemie - International Edition
    巻
    55
    ページ
    14606-14609
    年
    2016
    DOI
    10.1002/anie.201607474
    PMID
    Online published
    2016 Oct 20
  • Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib
    著者
    Nishiya, Yumi., Nakai, Daisuke., Urasaki, Yoko., Takakusa, Hideo., Ohsuki, Satoru., Iwano, Yuji., Yasukochi, Takanori., Takayama, Tomoko., Bazyo, Shohei., Oza, Chikahiro., Kurihara, Atsushi., Savage, Ronald E.., Izumi, Takashi.
    雑誌名
    Xenobiotica
    巻
    46
    ページ
    967-976
    年
    2016
    DOI
    10.3109/00498254.2016.1144896
    PMID
    Online published
    2016 Feb 22
  • Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate
    著者
    Ohtoyo, Mamoru., Machinaga, Nobuo., Inoue, Ryotaku., Hagihara, Katsunobu., Yuita, Hiroshi., Tamura, Masakazu., Hashimoto, Ryuji., Chiba, Jun., Muro, Fumihito., Watanabe, Jun., Kobayashi, Yoshimasa., Abe, Koji., Kita, Yasuo., Nagasaki, Miyuki., Shimozato, Takaichi.
    雑誌名
    Cell Chemical Biology
    巻
    23
    ページ
    555-560
    年
    2016
    DOI
    10.1016/j.chembiol.2016.04.007
    PMID
    Online published
    2016 May 19
  • Advantage of the Dissolution/Permeation System for Estimating Oral Absorption of Drug Candidates in the Drug Discovery Stage
    著者
    Miyaji, Yoshihiro., Fujii, Yoshimine., Takeyama, Shoko., Kawai, Yukinori., Kataoka, Makoto., Takahashi, Masayuki., Yamashita, Shinji.
    雑誌名
    Molecular Pharmaceutics
    巻
    13
    ページ
    1564-1574
    年
    2016
    DOI
    10.1021/acs.molpharmaceut.6b00044
    PMID
    Online published
    2016 Apr 13
  • The Role of a Nonribosomal Peptide Synthetase in l -Lysine Lactamization during Capuramycin Biosynthesis
    著者
    Liu, Xiaodong., Jin, Yuanyuan., Cui, Zheng., Nonaka, Koichi., Baba, Satoshi., Funabashi, Masanori., Yang, Zhaoyong., Van Lanen, Steven G.
    雑誌名
    ChemBioChem
    巻
    17
    ページ
    804-810
    年
    2016
    DOI
    10.1002/cbic.201500701
    PMID
    Online published
    2016 Mar 18
  • Characterization of a novel oxidase from Thelonectria discophora SANK 18292 involved in nectrisine biosynthesis
    著者
    Miyauchi, Ryuki., Sakurai, Hidetaka., Shiba, Yoichiro.
    雑誌名
    AMB Express
    巻
    6
    ページ
    6
    年
    2016
    DOI
    10.1186/s13568-016-0176-1
    PMID
    26786316
    Online published
    2016 Jan 20
  • A study of the properties of chlorine dioxide gas as a fumigant
    著者
    Shirasaki, Yasufumi., Matsuura, Ayumi., Uekusa, Masashi., Ito, Yoshihiro., Hayashi, Toshiaki.
    雑誌名
    Experimental Animals
    巻
    65
    ページ
    303-310
    年
    2016
    DOI
    10.1538/expanim.15-0092
    PMID
    Online published
    2016 Apr 04
  • Human intestinal raf kinase inhibitor protein (RKIP) catalyzes prasugrel as a bioactivation hydrolase
    著者
    Kazui, Miho., Ogura, Yuji., Hagihara, Katsunobu., Kubota, Kazuishi., Kurihara, Atsushi.
    雑誌名
    Drug Metabolism and Disposition
    巻
    44
    ページ
    115-223
    年
    2016
    DOI
    10.1124/dmd.115.066290
    PMID
    Online published
    2015 Dec 08
  • Evaluation of species difference in peripheral lymphocyte reduction effect of CS-0777, a sphingosine 1-phosphate receptor modulator, based on a pharmacokinetic/pharmacodynamic model analysis
    著者
    Inaba, Shin Ichi., Goto, Maki., Tanaka-takanaka, Kaoru., Tanaka, Hisako., Tomisato, Wataru., Yuita, Hiroshi., Doi-Komuro, Hiromi., Inoue, Ryotaku., Oshima, Keiko., Kagari, Takashi., Shimozato, Takaichi., Izumi, Takashi.
    雑誌名
    Biopharmaceutics and Drug Disposition
    巻
    37
    ページ
    561-573
    年
    2016
    DOI
    10.1002/bdd.2048
    PMID
    Online published
    2016 Nov 14
  • Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development
    著者
    Masubuchi, Noriko., Nishiya, Takayoshi., Imaoka, Masako., Mizumaki, Kiyoko., Okazaki, Osamu.
    雑誌名
    Chemico-Biological Interactions
    巻
    255
    ページ
    74-82
    年
    2016
    DOI
    10.1016/j.cbi.2015.09.012
    PMID
    Online published
    2015 Sep 11
  • Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor
    著者
    Ogiyama, Tomoko., Yamaguchi, Mitsuhiro., Kurikawa, Nobuya., Honzumi, Shoko., Yamamoto, Yuka., Sugiyama, Daisuke., Inoue, Shinichi.
    雑誌名
    Bioorganic & medicinal chemistry
    巻
    24
    ページ
    3801-7
    年
    2016
    DOI
    10.1016/j.bmc.2016.06.022
    PMID
    27338659
    Online published
    2016 Jun 11
  • SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation
    著者
    Doiguchi, Masamichi., Nakagawa, Takeya., Imamura, Yuko., Yoneda, Mitsuhiro., Higashi, Miki., Kubota, Kazuishi., Yamashita, Satoshi., Asahara, Hiroshi., Iida, Midori., Fujii, Satoshi., Ikura, Tsuyoshi., Liu, Ziying., Nandu, Tulip., Kraus, W. Lee., Ueda, Hitoshi., Ito, Takashi.
    雑誌名
    Scientific Reports
    巻
    6
    ページ
    20179
    年
    2016
    DOI
    10.1038/srep20179
    PMID
    Online published
    2016 Feb 18
  • Medication-taking behavior in hypertensive patients with a single-tablet, fixed-dose combination in Japan
    著者
    Saito, Ikuo., Kushiro, Toshio., Matsushita, Yasuyuki., Sato, Yuki., Sagawa, Kei., Tanaka, Yuko., Tanigawa, Masatoshi., Okutani, Yukihiro.
    雑誌名
    Clinical and Experimental Hypertension
    巻
    38
    ページ
    131-136
    年
    2016
    DOI
    10.3109/10641963.2015.1047949
    PMID
    Online published
    2015 Jul 24

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