主な投稿論文

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Achievements主な投稿論文

  • Target identification of hepcidin production inhibitors by a combination of chemical proteomics and radioactive compound binding assay
    著者
    Sasaki, Masato., Ueda, Kenjiro., Fukuda, Takeshi., Tanaka, Naoki., Shimizu, Hiroki., Kubota, Kazuishi.
    雑誌名
    Biochemical and Biophysical Research Communications
    503
    ページ
    2878-2884
    2018
    DOI
    10.1016/j.bbrc.2018.08.061
    PMID
    Online published
    2018 Aug 21
  • Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Shimada, Kousei., Onishi, Yoshiyuki., Matsui, Yumi., Wakimoto, Satoko., Kuroha, Masanori., Ogata, Tsuneaki., Araki, Kazushi., Ohsumi, Jun., Sawamura, Ryoko., Watanabe, Nobuaki., Yamamoto, Hideki., Fujimoto, Kazunori., Tani, Yoshiro., Mori, Makoto., Tanaka, Jun.
    雑誌名
    Bioorganic and Medicinal Chemistry
    26
    ページ
    5099-5117
    2018
    DOI
    10.1016/j.bmc.2018.09.005
    PMID
    30220602
    Online published
    2018 Sep 08
  • Plasma citrulline is a sensitive safety biomarker for small intestinal injury in rats
    著者
    Saitoh, Wataru., Takada, Sanae., Hirao, Jun., Shirai, Makoto., Iguchi, Takuma., Tsuji, Makoto., Nishiya, Takayoshi., Mori, Kazuhiko.
    雑誌名
    Toxicology Letters
    295
    ページ
    416-423
    2018
    DOI
    10.1016/j.toxlet.2018.07.009
    PMID
    Online published
  • Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Shimada, Kousei., Onishi, Yoshiyuki., Matsui, Yumi., Wakimoto, Satoko., Kuroha, Masanori., Ogata, Tsuneaki., Araki, Kazushi., Ohsumi, Jun., Sawamura, Ryoko., Watanabe, Nobuaki., Yamamoto, Hideki., Fujimoto, Kazunori., Tani, Yoshiro., Mori, Makoto., Tanaka, Jun.
    雑誌名
    Bioorganic and Medicinal Chemistry
    26
    ページ
    5079-5098
    2018
    DOI
    10.1016/j.bmc.2018.09.006
    PMID
    30241907
    Online published
    2018 May 23
  • Detection of dystrophin Dp71 in human skeletal muscle using an automated capillary western assay system
    著者
    Kawaguchi, Tatsuya., Niba, Emma Tabe Eko., Rani, Abdul Qawee Mahyoob., Onishi, Yoshiyuki., Koizumi, Makoto., Awano, Hiroyuki., Matsumoto, Masaaki., Nagai, Masashi., Yoshida, Shinobu., Sakakibara, Sachiko., Maeda, Naoyuki., Sato, Osamu., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    International Journal of Molecular Sciences
    19
    ページ
    1546
    2018
    DOI
    10.3390/ijms19061546
    PMID
    Online published
    2018 May 23
  • Biocompatible Polymers Modified with d -Octaarginine as an Absorption Enhancer for Nasal Peptide Delivery
    著者
    Miyata, Kohei., Ukawa, Masami., Mohri, Kohta., Fujii, Kozue., Yamada, Mako., Tanishita, Sohei., Higashitarumi, Satoshi., Ishizaki, Seiya., Kumagai, Hironori., Ochiai, Kyohei., Hiwatari, Ken Ichiro., Tsubaki, Kazufumi., Shigeno, Koichi., Tobita, Etsuo., Kobayashi, Hideo., Sakuma, Shinji.
    雑誌名
    Bioconjugate Chemistry
    29
    ページ
    1748-1755
    2018
    DOI
    10.1021/acs.bioconjchem.8b00185
    PMID
    Online published
    2018 Apr 12
  • Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans
    著者
    Inaba, Shin-Ichi., Yamaguchi-Goto, Maki., Tanaka-Takanaka, Kaoru., Yonesu, Kiyoaki., Sakurai, Hidetaka., Kubota, Kazuishi., Izumi, Takashi.
    雑誌名
    Xenobiotica; the fate of foreign compounds in biological systems
    48
    ページ
    258-268
    2018
    DOI
    10.1080/00498254.2017.1306150
    PMID
    28287856
    Online published
    2017 Apr 03
  • A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1
    著者
    Matsui, Yumi., Yasumatsu, Isao., Yoshida, Ken Ichi., Iimura, Shin., Ikeno, Yutaka., Nawano, Takako., Fukano, Hajime., Ubukata, Osamu., Hanzawa, Hiroyuki., Tanzawa, Fumie., Isoyama, Takeshi.
    雑誌名
    Acta Crystallographica Section F: Structural Biology Communications
    74
    ページ
    156-160
    2018
    DOI
    10.1107/S2053230X18002108
    PMID
    Online published
    2018 Feb 26
  • Alkylsulfanyl analogs as potent α 2 δ ligands
    著者
    Shimada, Kousei., Ohata, Yasuo., Kobayashi, Jun., Onishi, Yoshiyuki., Kawamura, Asuka., Domon, Yuki., Arakawa, Naohisa., Inoue, Tatsuya., Kitano, Yutaka., Matsuda, Fumihiko., Abe, Yuki., Deguchi, Tsuneo.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    28
    ページ
    2000-2002
    2018
    DOI
    10.1016/j.bmcl.2018.05.006
    PMID
    Online published
    2018 May 04
  • UNC569-induced Morphological Changes in Pigment Epithelia and Photoreceptor Cells in the Retina through MerTK Inhibition in Mice
    著者
    Sayama, Ayako., Okado, Keiko., Nakamura, Koichi., Kawaguchi, Tatsuya., Iguchi, Takuma., Makino, Toshihiko., Yabe, Koichi., Kai, Kiyonori., Mori, Kazuhiko.
    雑誌名
    Toxicologic Pathology
    46
    ページ
    193-201
    2018
    DOI
    10.1177/0192623317749469
    PMID
    Online published
    2019 Jan 08
  • Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens
    著者
    Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Kitamura, Takahiro., Komoriya, Satoshi., Takahashi, Hisashi.
    雑誌名
    Journal of Medicinal Chemistry
    61
    ページ
    7234-7244
    2018
    DOI
    10.1021/acs.jmedchem.8b00644
    PMID
    Online published
    2018 Jul 31
  • Phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral doses of ds-2969b, a novel gyrb inhibitor, in healthy subjects
    著者
    Vandell, Alexander G.., Inoue, Satoshi., Dennie, Justin., Nagasawa, Yasuo., Gajee, Roohi., Pav, Joe., Zhang, George., Zamora, Cynthia., Masuda, Nobuhisa., Senaldi, Giorgio.
    雑誌名
    Antimicrobial Agents and Chemotherapy
    62
    ページ
    -
    2018
    DOI
    10.1128/AAC.02537-17
    PMID
    Online published
    2018 Apr 26