主な投稿論文

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Achievements主な投稿論文

  • Preclinical Development of U3-1784, a Novel FGFR4 Antibody against Cancer, and Avoidance of Its On-target Toxicity
    著者
    Bartz, Rene., Fukuchi, Keisuke., Ohtsuka, Toshiaki., Lange, Tanja., Gruner, Katrin., Watanabe, Ichiro., Hayashi, Shinko., Oda, Yoko., Kawaida, Reimi., Komori, Hironobu., Kashimoto, Yoshinori., Wirtz, Peter., Mayer, Jan Peter A.., Redondo-Muller, Mauricio., Saito, Shuntaro., Takahashi, Mizuki., Hanzawa, Hiroyuki., Imai, Emi., Martinez, Alberto., Hanai, Masaharu., Haussinger, Dieter., Chapman, Roger W.., Agatsuma, Toshinori., Bange, Johannes., Abraham, Reimar.
    雑誌名
    Molecular Cancer Therapeutics
    18
    ページ
    1832-1843
    2019
    DOI
    10.1158/1535-7163.MCT-18-0048
    PMID
    Online published
    2019 Jul 26
  • Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
    著者
    Kawai, Junya., Toki, Tadashi., Ota, Masahiro., Inoue, Hidekazu., Takata, Yoshimi., Asahi, Takashi., Suzuki, Makoto., Shimada, Takashi., Ono, Kaori., Suzuki, Kanae., Takaishi, Sachiko., Ohki, Hitoshi., Matsui, Satoshi., Tsutsumi, Shinji., Hirota, Yasuhide., Nakayama, Kiyoshi.
    雑誌名
    Journal of medicinal chemistry
    62
    ページ
    10204-10220
    2019
    DOI
    10.1021/acs.jmedchem.9b01113
    PMID
    31638799
    Online published
    2019 Oct 22
  • Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold
    著者
    Kawai, Junya., Ota, Masahiro., Ohki, Hitoshi., Toki, Tadashi., Suzuki, Makoto., Shimada, Takashi., Matsui, Satoshi., Inoue, Hidekazu., Sugihara, Chika., Matsuhashi, Norikazu., Matsui, Yumi., Takaishi, Sachiko., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    893-898
    2019
    DOI
    10.1021/acsmedchemlett.9b00069
    PMID
    Online published
    2019 May 24
  • Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity
    著者
    Taniguchi, Toru., Inagaki, Hiroaki., Baba, Daichi., Yasumatsu, Isao., Toyota, Akiko., Kaneta, Yasuyuki., Kiga, Masaki., Iimura, Shin., Odagiri, Takashi., Shibata, Yoshihiro., Ueda, Kiyono., Seo, Maki., Shimizu, Hiroki., Imaoka, Tomoki., Nakayama, Kiyoshi.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    737-742
    2019
    DOI
    10.1177/0192623318809062
    PMID
    Online published
    2019 Mar 15
  • Functional and Morphological Characteristics of Pancreatic Islet Lesions Induced by Quinolone Antimicrobial Agent Gatifloxacin in Rats
    著者
    Yabe, Koichi., Yamamoto, Yuka., Suzuki, Takami., Takada, Sanae., Mori, Kazuhiko.
    雑誌名
    Toxicologic pathology
    47
    ページ
    35-43
    2019
    DOI
    10.1177/0192623318809062
    PMID
    30407147
    Online published
    2018 Nov 08
  • Practical one-step glucuronidation via biotransformation
    著者
    Ohnuki, Takashi., Ejiri, Masahiko., Kizuka, Masaaki., Fujiwara, Mie., Nishi, Takahide.
    雑誌名
    Bioorganic and Medicinal Chemistry Letters
    29
    ページ
    199-203
    2019
    DOI
    2019
    PMID
    Online published
    2018 Nov 28
  • Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones
    著者
    Komoriya, Satoshi., Odagiri, Takashi., Inagaki, Hiroaki., Nagamochi, Masatoshi., Miyauchi, Rie., Yoshida, Ken-Ichi., Kitamura, Takahiro., Takahashi, Hisashi.
    雑誌名
    Chemical & pharmaceutical bulletin
    67
    ページ
    47-58
    2019
    DOI
    10.1248/cpb.c18-00671
    PMID
    30606950
    Online published
    2019 Jan 01
  • Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma
    著者
    Nakagawa, Makoto., Fujita, Shuhei., Katsumoto, Takuo., Yamagata, Kazutsune., Ogawara, Yoko., Hattori, Ayuna., Kagiyama, Yuki., Honma, Daisuke., Araki, Kazushi., Inoue, Tatsuya., Kato, Ayako., Inaki, Koichiro., Wada, Chisa., Ono, Yoshimasa., Yamamoto, Masahide., Miura, Osamu., Nakashima, Yasuharu., Kitabayashi, Issay.
    雑誌名
    Cancer Science
    110
    ページ
    194-208
    2019
    DOI
    10.1111/cas.13840
    PMID
    30343511
    Online published
    2018 Nov 16
  • Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches
    著者
    Kubota, Kazuishi., Funabashi, Masanori., Ogura, Yuji.
    雑誌名
    Biochimica et Biophysica Acta - Proteins and Proteomics
    1867
    ページ
    22-27
    2019
    DOI
    10.1016/j.bbapap.2018.08.002
    PMID
    30392561
    Online published
  • Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology
    著者
    Ohki, Yu., Sakurai, Hidetaka., Hoshino, Madoka., Terashima, Hideki., Shimizu, Hiroki., Ishikawa, Tomio., Ogiyama, Tomoko., Muramatsu, Yasunori., Nakanishi, Toshiyuki., Miyazaki, Shojiro., Tsuruoka, Hiroyuki., Kobayashi, Hideki., Kubota, Kazuishi.
    雑誌名
    Cell chemical biology
    26
    ページ
    137-143.e8
    2019
    DOI
    10.1016/j.chembiol.2018.10.012
    PMID
    30449674
    Online published
    2018 Nov 15
  • Identification of the shortest splice variant of Dp71, together with five known variants, in glioblastoma cells
    著者
    Rani, Abdul Qawee Mahyoob., Farea, Manal., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Biochemical and Biophysical Research Communications
    508
    ページ
    640-645
    2019
    DOI
    10.1016/j.bbrc.2018.11.168
    PMID
    Online published
    2018 Dec 05
  • Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
    著者
    Terashima, Hideki., Aonuma, Misato., Tsuchida, Hiroshi., Sugimoto, Kotaro., Yokoyama, Mika., Kato, Mikio.
    雑誌名
    Pulmonary Pharmacology & Therapeutics
    54
    ページ
    31-38
    2019
    DOI
    10.1016/j.pupt.2018.11.005
    PMID
    30448291
    Online published
    2018 Nov 15
  • Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930
    著者
    Shinozuka, Tsuyoshi., Tsukada, Tomoharu., Fujii, Kunihiko., Tokumaru, Eri., Matsui, Yumi., Wakimoto, Satoko., Ogata, Tsuneaki., Araki, Kazushi., Sawamura, Ryoko., Watanabe, Nobuaki., Mori, Makoto., Tanaka, Jun.
    雑誌名
    ACS Medicinal Chemistry Letters
    10
    ページ
    358-362
    2019
    DOI
    10.1021/acsmedchemlett.8b00645
    PMID
    Online published
    2019 Feb 26
  • Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation
    著者
    Kishino, Yuki., Hasegawa, Tomoko., Kato, Ayako., Nishiya, Yumi., Rozhnal, Veronika., Watanabe, Kyoko., Takasaki, Wataru., Yamoto, Takashi., Mori, Kazuhiko.
    雑誌名
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis
    838
    ページ
    37-45
    2019
    DOI
    10.1016/j.mrgentox.2018.11.016
    PMID
    Online published
    2018 Dec 05
  • Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization
    著者
    Fujita, Yoko., Kagoshima, Yoshiko., Masuda, Takeshi., Kizuka, Masaaki., Ogawa, Yasumasa., Endo, Shuichi., Nishigoori, Hideaki., Saito, Kazuko., Takasugi, Kunio., Miura, Masami., Murakami, Ryo., Muramatsu, Yasunori., Tokumitsu, Akane., Koga, Tetsufumi., Iizuka, Mayumi., Aoyagi, Azusa., Suzuki, Toshihiro., Suzuki, Takashi., Suzuki, Yasuhiro., Ishida, Osamu., Nakahira, Toru., Miyakoshi, Shunichi., Konosu, Toshiyuki., Takatsu, Toshio.
    雑誌名
    The Journal of antibiotics
    72
    ページ
    943-955
    2019
    DOI
    10.1038/s41429-019-0215-7
    PMID
    31413314
    Online published
    2019 Aug 14
  • Schwann cell-specific Dp116 is expressed in glioblastoma cells, revealing two novel DMD gene splicing patterns
    著者
    Mahyoob Rani, Abdul Qawee., Maeta, Kazuhiro., Kawaguchi, Tatsuya., Awano, Hiroyuki., Nagai, Masashi., Nishio, Hisahide., Matsuo, Masafumi.
    雑誌名
    Biochemistry and biophysics reports
    20
    ページ
    100703
    2019
    DOI
    10.1016/j.bbrep.2019.100703
    PMID
    31737793
    Online published
    2019 Nov 10
  • Muraminomicins, novel ester derivatives: in vitro and in vivo antistaphylococcal activity
    著者
    Kagoshima, Yoshiko., Tokumitsu, Akane., Masuda, Takeshi., Namba, Eiko., Inoue, Harumi., Sugihara, Chika., Yokoyama, Mizuka., Yamamoto, Yuko., Suzuki, Keiko., Iida, Kouki., Tamura, Akihiro., Fujita, Yoko., Takatsu, Toshio., Konosu, Toshiyuki., Koga, Tetsufumi.
    雑誌名
    The Journal of antibiotics
    72
    ページ
    956-969
    2019
    DOI
    10.1038/s41429-019-0235-3
    PMID
    31558775
    Online published
    2019 Sep 27
  • Harmonizing solubility measurement to lower inter-laboratory variance – progress of consortium of biopharmaceutical tools (CoBiTo) in Japan
    著者
    Ono, Asami., Matsumura, Naoya., Kimoto, Takahiro., Akiyama, Yoshiyuki., Funaki, Satoko., Tamura, Naomi., Hayashi, Shun., Kojima, Yukiko., Fushimi, Masahiro., Sudaki, Hiroshi., Aihara, Risa., Haruna, Yuka., Jiko, Maiko., Iwasaki, Masaru., Fujita, Takuya., Sugano, Kiyohiko.
    雑誌名
    ADMET & DMPK
    7
    ページ
    183-195
    2019
    DOI
    10.5599/admet.704
    PMID
    Online published
    2019 Aug 05
  • The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
    著者
    Katayama, Ryohei., Gong, Bo., Togashi, Noriko., Miyamoto, Masaya., Kiga, Masaki., Iwasaki, Shiho., Kamai, Yasuki., Tominaga, Yuichi., Takeda, Yasuyuki., Kagoshima, Yoshiko., Shimizu, Yuki., Seto, Yosuke., Oh-hara, Tomoko., Koike, Sumie., Nakao, Naoki., Hanzawa, Hiroyuki., Watanabe, Kengo., Yoda, Satoshi., Yanagitani, Noriko., Hata, Aaron N.., Shaw, Alice T.., Nishio, Makoto., Fujita, Naoya., Isoyama, Takeshi.
    雑誌名
    Nature Communications
    10
    ページ
    3604
    2019
    DOI
    10.1038/s41467-019-11496-z
    PMID
    Online published
    2019 Aug 09
  • DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model
    著者
    Jimbo, Takeshi., Hatanaka, Mana., Komatsu, Takahiro., Taira, Tomoe., Kumazawa, Kentaro., Maeda, Naoyuki., Suzuki, Takashi., Ota, Masahiro., Haginoya, Noriyasu., Isoyama, Takeshi., Fujiwara, Kosaku.
    雑誌名
    Oncotarget
    10
    ページ
    5152-5167
    2019
    DOI
    10.18632/oncotarget.27114
    PMID
    31497246
    Online published
    2019 Aug 27
  • Memantine ameliorates learning and memory disturbance and the behavioral and psychological symptoms of dementia in thiamine-deficient mice
    著者
    Makino, Mitsuhiro., Takahashi-Ito, Kaori., Murasawa, Hiroyasu., Pawlak, Akiko., Kashimoto, Yoshinori., Kitano, Yutaka.
    雑誌名
    Pharmacology Biochemistry and Behavior
    183
    ページ
    6-13
    2019
    DOI
    10.1016/j.pbb.2019.05.008
    PMID
    Online published
    2019 Jun 05
  • In Vitro Assessment of Supersaturation/Precipitation and Biological Membrane Permeation of Poorly Water-Soluble Drugs: A Case Study With Albendazole and Ketoconazole
    著者
    Kataoka, Makoto., Takeyama, Shoko., Minami, Keiko., Higashino, Haruki., Kakimi, Kohichi., Fujii, Yoshimine., Takahashi, Masayuki., Yamashita, Shinji.
    雑誌名
    Journal of Pharmaceutical Sciences
    108
    ページ
    2580-2587
    2019
    DOI
    10.1016/j.xphs.2019.03.007
    PMID
    Online published
    2019 Mar 15