主な投稿論文

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Achievements主な投稿論文

  • Expanded precision medicine capabilities for strengthening oncology drug development at Daiichi Sankyo
    著者
    Murakami, Masato., Tokui, Taro., Nakamaru, Kenji., Cogswell, John., Ford, Shirin Khambata., Gallant, Gilles.
    雑誌名
    Journal of Precision Medicine
    7
    ページ
    14-19
    2021
    DOI
    https://www.thejournalofprecisionmedicine.com/wp-content/uploads/expanded-precision.pdf
    PMID
    Online published
  • 4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors
    著者
    Kanada, Ryutaro., Suzuki, Takashi., Murata, Takeshi., Miyazaki, Masaki., Shimada, Takashi., Kuroha, Mutsumi., Minami, Megumi., Higuchi, Saito., Tominaga, Yuichi., Naito, Hiroyuki.
    雑誌名
    Bioorg Med Chem Lett
    51
    ページ
    128358
    2021
    DOI
    10.1016/j.bmcl.2021.128358
    PMID
    34534674
    Online published
    2021 Sep 14
  • New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)
    著者
    Masada,Takato., Takagi, Toshihide., Minami, Keiko., Kataoka, Makoto., Takeyama, Shoko., Fujii, Yoshimine., Takahashi, Masayuki., Yamashita, Shinji.
    雑誌名
    Journal of Drug Delivery Science and Technology
    65
    ページ
    102747
    2021
    DOI
    10.1016/j.jddst.2021.102747
    PMID
    Online published
    2021 Jul 24
  • Reforms of regulatory pathways for approval of new antineoplastic drugs in Japan from 2004 to 2019 and accompanying changes in pivotal clinical trial designs
    著者
    Hirai, Takehiro., Suzuki, Asuka., Yamori, Takao., Matsuura, Masaaki.
    雑誌名
    Invest New Drugs
    40
    ページ
    142-150
    2022
    DOI
    10.1007/s10637-021-01165-8
    PMID
    34417913
    Online published
    2021 Aug 21
  • A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
    著者
    Furuzono, Shinji., Kubota,Tetsuya., Taura, Junki., Konishi, Masahiro., Naito, Asuka., Tsutsui, Masato., Karasawa, Hiroshi., Kubota, Naoto., Kadowaki, Takashi.
    雑誌名
    Commun Biol
    4
    ページ
    994
    2021
    DOI
    10.1038/s42003-021-02491-6
    PMID
    34417555
    Online published
    2021 Aug 20
  • Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells
    著者
    Satoh, Kazuki., Kobayashi, Yoichi., Fujimaki, Kaori., Hayashi, Shinko., Ishida, Saori., Sugiyama, Daisuke., Sato, Takahiko., Lim, Kyungtaek., Miyamoto, Megumi., Kozuma, Shiho., Kadokura, Michinori., Wakita, Kenichi., Hata, Masato., Hirahara, Kazuki., Amano, Masato., Watanabe, Ichiro., Okamoto, Atsushi., Tuettenberg, Andrea., Jonuleit, Helmut., Tanemura, Atsushi., Maruyama, Shoichi., Agatsuma, Toshinori., Wada, Teiji., Nishikawa, Hiroyoshi.
    雑誌名
    Int Immunol
    33
    ページ
    435-446
    2021
    DOI
    10.1093/intimm/dxab027
    PMID
    34235533
    Online published
    2021 Jun 03
  • Corrigendum to “Syntheses and antimicrobial activities of ogipeptin derivatives” [Bioorg. Med. Chem. Lett. 42 (2021) 128093]
    著者
    Takiguchi, Shingo., Homma, Hidehito., Fujisawa, Tetsunori., Hirota-Takahata, Yuki., Ono, Yasunori., Kizuka, Masaaki., Ishii, Yuki., Yoshimura, Satomichi., Nishi, Takahide.
    雑誌名
    Bioorg Med Chem Lett
    47
    ページ
    128228
    2021
    DOI
    10.1016/j.bmcl.2021.128228
    PMID
    34192636
    Online published
    2021 Jun 27
  • Edoxaban, a direct oral factor Xa inhibitor, ameliorates coagulation, microvascular thrombus formation, and acute liver injury in a lipopolysaccharide-induced coagulopathy model in rats
    著者
    Morishima, Yoshiyuki., Shibutani, Tomoko., Noguchi, Kengo., Ito, Yusuke., Honda, Yuko.
    雑誌名
    J Thromb Thrombolysis
    52
    ページ
    9-17
    2021
    DOI
    10.1007/s11239-021-02381-y
    PMID
    33534029
    Online published
    2021 Feb 03
  • Discovery of a Novel Class of ERRα Agonists
    著者
    Shinozuka, Tsuyoshi., Ito, Shuichiro., Kimura, Takako., Izumi, Masanori., Wakabayashi, Kenji.
    雑誌名
    ACS Med Chem Lett
    12
    ページ
    817-821
    2021
    DOI
    10.1021/acsmedchemlett.1c00100
    PMID
    34055231
    Online published
    2021 Apr 21
  • Syntheses and antimicrobial activities of ogipeptin derivatives
    著者
    Takiguchi, Shingo., Homma, Hidehito., Fujisawa, Tetsunori., Hirota-Takahata, Yuki., Ono, Yasunori., Kizuka, Masaaki., Ishii, Yuki., Yoshimura, Satomichi., Nishi, Takahide.
    雑誌名
    Bioorg Med Chem Lett
    42
    ページ
    128093
    2021
    DOI
    10.1016/j.bmcl.2021.128093
    PMID
    33964447
    Online published
    2021 May 06
  • CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib
    著者
    Kagiyama, Yuki., Fujita, Shuhei., Shima, Yutaka., Yamagata, Kazutsune., Katsumoto, Takuo., Nakagawa, Makoto., Honma, Daisuke., Adachi, Nobuaki., Araki, Kazushi., Kato, Ayako., Inaki, Koichiro., Ono, Yoshimasa., Fukuhara, Suguru., Kobayashi, Yukio., Tobinai, Kensei., Kitabayashi, Issay.
    雑誌名
    Cancer Sci
    112
    ページ
    2314-2324
    2021
    DOI
    10.1111/cas.14905
    PMID
    33792119
    Online published
    2021 May 01
  • Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate
    著者
    Iida, Kenji., Ahmed, Amr H Abdelhamid., Nagatsuma, Akiko Kawano., Shibutani, Tomoko., Yasuda, Satoru., Kitamura, Michiko., Hattori, Chiharu., Abe, Manabu., Hasegawa, Jun., Iguchi, Takuma., Karibe, Tsuyoshi., Nakada, Takashi., Inaki, Koichiro., Kamei, Reiko., Abe, Yuki., Nomura, Taisei., Andersen, Jessica L., Santagata, Sandro., Hemming, Matthew L., George, Suzanne., Doi, Toshihiko., Ochiai, Atsushi., Demetri, George D., Agatsuma, Toshinori.
    雑誌名
    Cancer Discov
    11
    ページ
    1508-1523
    2021
    DOI
    10.1158/2159-8290.CD-20-1434
    PMID
    33579785
    Online published
    2021 Feb 12
  • Cryo-EM Structure of K +-Bound hERG Channel Complexed with the Blocker Astemizole
    著者
    Asai, Tatsuki., Adachi, Naruhiko., Moriya, Toshio., Oki, Hideyuki., Maru, Takamitsu., Kawasaki, Masato., Suzuki, Kano., Chen, Sisi., Ishii, Ryohei., Yonemori, Kazuko., Igaki, Shigeru., Yasuda, Satoshi., Ogasawara Satoshi., Senda. Toshiya., Murata, Takeshi.
    雑誌名
    Structure
    29
    ページ
    203-212
    2021
    DOI
    10.1016/j.str.2020.12.007
    PMID
    33450182
    Online published
    2021 Jan 14
  • Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions
    著者
    Suzuki, Kyosuke., Kawakami, Kohsaku., Fukiage, Masafumi., Oikawa, Michinori., Nishida, Yohei., Matsuda, Maki., Fujita, Takuya.
    雑誌名
    Pharmaceutics
    13
    ページ
    220
    2021
    DOI
    10.3390/pharmaceutics13020220
    PMID
    33562770
    Online published
    2021 Feb 05
  • Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
    著者
    Karlsson, Håkan K. R., Kasahara, Akiko., Ikeda, Mika., Chibalin, Alexander V., Harada, Jun., Rydén, Mikael., Krook, Anna., Kato, Mitsunori., Kubota, Kazuishi., Zierath, Juleen R.
    雑誌名
    Metabolism
    118
    ページ
    154726
    2021
    DOI
    10.1016/j.metabol.2021.154726
    PMID
    33581131
    Online published
    2021 Feb 11
  • Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease
    著者
    Katayama, Katsushi., Ishii, Ken., Terashima, Hideki., Tsuda, Eisuke., Suzuki, Makoto., Yotsumoto, Keiichi., Hiramoto, Kumiko., Yasumatsu, Isao., Torihata, Munefumi., Ishiyama, Takashi., Muto, Tsuyoshi., Katagiri, Takahiro.
    雑誌名
    ACS Med Chem Lett
    12
    ページ
    121-128
    2021
    DOI
    10.1021/acsmedchemlett.0c00572
    PMID
    Online published
    2020 Dec 28
  • Conformational plasticity of cyclic Ras-inhibitor peptides defines cell permeabilization activity
    著者
    Takeuchi, Koh., Misaki, Imai., Tokunaga, Yuji., Fujisaki, Miwa., Kamoshida, Hajime., Takizawa, Takeshi., Hanzawa, Hiroyuki ., Shimada, Ichio.
    雑誌名
    Angew Chem Int Ed Engl
    60
    ページ
    6567-6572
    2021
    DOI
    10.1002/anie.202016647
    PMID
    33427372
    Online published
    2021 Jan 11
  • Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation
    著者
    Nishimura, Masanori., Yamashita, Atsushi., Matsuura, Yunosuke., Okutsu, Junichi., Fukahori, Aiko., Hirata, Tsuyoshi., Nishizawa, Tomohiro., Ishii, Hirohito., Maekawa, Kazunari., Nakamura, Eriko., Kitamura, Kazuo., Nakamura, Kunihide., Asada, Yujiro.
    雑誌名
    J Atheroscler Thromb
    28
    ページ
    1214-1240
    2021
    DOI
    10.5551/jat.58248
    PMID
    33298635
    Online published
    2020 Dec 10
  • Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
    著者
    Guo, Chun-Jun., Chang, Fang-Yuan., Wyche, Thomas P., Backus, Keriann M., Acker, Timothy M., Funabashi, Masanori., Taketani, Mao., Donia, Mohamed S., Nayfach, Stephen., Pollard, Katherine S., Craik, Charles S., Cravatt, Benjamin F., Clardy, Jon., Voigt, Christopher A., Fischbach, Michael A.
    雑誌名
    Cell
    168
    ページ
    517-526
    2017
    DOI
    10.1016/j.cell.2016.12.021
    PMID
    28111075
    Online published
    2017 Jan 19
  • A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
    著者
    Nemet, Ina., Saha, Prasenjit Prasad., Gupta, Nilaksh., Zhu, Weifei., Romano, Kymberleigh A., Skye, Sarah M., Cajka, Tomas., Mohan, Maradumane L., Li, Lin., Wu, Yuping., Funabashi, Masanori., Ramer-Tait, Amanda E., Prasad, Sathyamangla Venkata Naga., Fiehn, Oliver., Rey, Federico E., Tang, W H Wilson., Fischbach, Michael A., DiDonato, Joseph A., Hazen, Stanley L.
    雑誌名
    Cell
    180
    ページ
    862-877
    2020
    DOI
    10.1016/j.cell.2020.02.016
    PMID
    32142679
    Online published
  • A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines
    著者
    Ogura, Yuji., Parsons, William H., Kamat, Siddhesh S., Cravatt, Benjamin F.
    雑誌名
    Nat Chem Biol
    12
    ページ
    669-671
    2016
    DOI
    10.1038/nchembio.2127
    PMID
    27399000
    Online published
    2016 Jul 11
  • Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV
    著者
    Reppas, Christos., Vrettos, Napoleon-Nikolaos., Dressman, Jennifer., Andreas, Cord J., Miyaji, Yoshihiro., Brown, Jonathan., Etherson, Kelly., Hanley, Sarah., Karkossa, Frank., Karlsson, Eva., Klein, Sandra., Maier, Gerd-Michael., McAllister, Mark., Mistry, Nena., Rosenblatt, Karin., Schäfer, Kerstin Julia., Smith, Kieran Lewis., Tomaszewska, Irena., Williams, James., Winge, Fredrik., Vertzoni Maria.
    雑誌名
    Eur J Pharm Biopharm "
    156
    ページ
    40-49
    2020
    DOI
    10.1016/j.ejpb.2020.08.025
    PMID
    32882421
    Online published
    2020 Aug 31
  • Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models
    著者
    Sasaki, Masato., Delawary, Mina., Sakurai, Hidetaka., Kobayashi, Hideki., Nakao, Naoki., Tsuru, Hiromi., Fukushima, Yumiko., Honzumi, Shoko., Moriyama, Sachiko., Wada, Naoya., Kaneko, Toshio., Yamada, Keisuke., Terasaka, Naoki., Kubota, Kazuishi.
    雑誌名
    Arteriosclerosis, Thrombosis, and Vascular Biology
    41
    ページ
    360-376
    2021
    DOI
    10.1161/ATVBAHA.120.314516
    PMID
    33086872
    Online published
    2020 Oct 22