-
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
- 著者
- Asano, Daigo., Hamaue, Syoya., Zahir, Hamim., Shiozawa, Hideyuki ., Nishiya, Yumi., Kimura, Takako., Kazui, Miho., Yamamura, Naotoshi., Ikeguchi, Marie., Shibayama, Takahiro., Inoue, Shin-Ichi., Shinozuka, Tsuyoshi., Watanabe, Toshiyuki., Yahara, Chizuko., Watanabe, Nobuaki., Yoshinari, Kouichi.
- 雑誌名
- Drug Metab Dispos
- DOI
- 10.1124/dmd.121.000665
- PMID
- 34930785
- Online published
- 2021 Dec 20
-
DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
- 著者
- Yamato,Michiko., Hasegawa, Jun., Maejima, Takanori., Hattori, Chiharu., Kumagai, Kazuyoshi., Watanabe, Akiko., Nishiya, Yumi., Shibutani, Tomoko., Aida, Tetsuo., Hayakawa, Ichiro., Nakada, Takashi., Abe, Yuki., Agatsuma, Toshinori.
- 雑誌名
- Mol Cancer Ther
- DOI
- 10.1158/1535-7163.MCT-21-0554
- PMID
- 35149548
- Online published
- 2022 Feb 11
-
A gut-derived metabolite alters brain activity and anxiety behaviour in mice
- 著者
- Needham, Brittany D., Funabashi, Masanori., Adame, Mark D., Wang, Zhuo., Boktor, Joseph C., Haney, Jillian., Wu, Wei-Li., Rabut, Claire., Ladinsky, Mark S., Hwang, Son-Jong., Guo, Yumei., Zhu, Qiyun., Griffiths, Jessica A., Knight , Rob., Bjorkman, Pamela J., Shapiro, Mikhail G., Geschwind, Daniel H., Holschneider, Daniel P., Fischbach, Michael A., Mazmanian, Sarkis K.
- 雑誌名
- Nature
- DOI
- 10.1038/s41586-022-04396-8
- PMID
- 35165440
- Online published
- 2022 Feb 14
-
HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non-Small Cell Lung Cancer
- 著者
- Yonesaka, Kimio., Tanizaki, Junko., Maenishi, Osamu., Haratani, Koji., Kawakami, Hisato., Tanaka, Kaoru., Hayashi, Hidetoshi., Sakai, Kazuko., Chiba, Yasutaka., Tsuya, Asuka., Goto, Hiroki., Otsuka, Eri., Okida, Hiroaki., Kobayashi, Maki., Yoshimoto, Ryoto., Funabashi, Masanori., Hashimoto, Yuuri., Hirotani, Kenji., Kagari, Takashi., Nishio, Kazuto., Nakagawa, Kazuhiko.
- 雑誌名
- Clin Cancer Res .
- DOI
- 10.1158/1078-0432.CCR-21-3359
- PMID
- 34921025
- Online published
- 2021 Dec 17
-
Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains
- 著者
- Hamasuna, Ryoichi., Hanzawa, Hiroyuki., Moritomo, Ayako., Matsumoto, Masahiro., Aono, Hisami., Tomisaki, Ikko., Akasaka, Takaaki., Fujimoto, Naohiro., SkovJensen, Jørgen.
- 雑誌名
- J Infect Chemother
- DOI
- 10.1016/j.jiac.2021.11.011
- PMID
- 34836778
- Online published
- 2021 Nov 24
-
Highly sensitive in vitro cytokine release assay incorporating high-density preculture
- 著者
- Ito, Shiho., Miwa, Kyoko., Hattori, Chiharu., Aida, Tetsuo., Tsuchiya, Yoshimi., Mori, Kazuhiko.
- 雑誌名
- J Immunotoxicol
- DOI
- 10.1080/1547691X.2021.1984617
- PMID
- 34644231
- Online published
- 2021 Oct 13
-
Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
- 著者
- Okajima, Daisuke.,Yasuda, Satoru., Maejima, Takanori., Karibe, Tsuyoshi., Sakurai, Ken., Aida, Tetsuo., Toki, Tadashi., Yamaguchi, Junko., Kitamura, Michiko., Kamei, Reiko., Fujitani, Tomomichi., Honda, Tomoyo., Shibutani, Tomoko., Muramatsu, Sumie., Nakada, Takashi., Goto, Riki., Takahashi, Shu., Yamaguchi, Miki., Hamada, Hirofumi., Noguchi, Yutaka., Murakami, Masato., Abe, Yuki., Agatsuma, Toshinori.
- 雑誌名
- Mol Cancer Ther
- 巻
- 20
- ページ
- 2329-2340
- 年
- 2021
- DOI
- 10.1158/1535-7163.MCT-21-0206
- PMID
- 34413126
- Online published
- 2021 Aug 19
詳しくみる