主な投稿論文

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  • CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
    著者
    Asano, Daigo., Hamaue, Syoya., Zahir, Hamim., Shiozawa, Hideyuki ., Nishiya, Yumi., Kimura, Takako., Kazui, Miho., Yamamura, Naotoshi., Ikeguchi, Marie., Shibayama, Takahiro., Inoue, Shin-Ichi., Shinozuka, Tsuyoshi., Watanabe, Toshiyuki., Yahara, Chizuko., Watanabe, Nobuaki., Yoshinari, Kouichi.
    雑誌名
    Drug Metab Dispos
    50
    ページ
    235-242
    2022
    DOI
    10.1124/dmd.121.000665
    PMID
    34930785
    Online published
    2021 Dec 20
  • DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
    著者
    Yamato,Michiko., Hasegawa, Jun., Maejima, Takanori., Hattori, Chiharu., Kumagai, Kazuyoshi., Watanabe, Akiko., Nishiya, Yumi., Shibutani, Tomoko., Aida, Tetsuo., Hayakawa, Ichiro., Nakada, Takashi., Abe, Yuki., Agatsuma, Toshinori.
    雑誌名
    Mol Cancer Ther
    21
    ページ
    635-646
    2022
    DOI
    10.1158/1535-7163.MCT-21-0554
    PMID
    35149548
    Online published
    2022 Feb 11
  • A gut-derived metabolite alters brain activity and anxiety behaviour in mice
    著者
    Needham, Brittany D., Funabashi, Masanori., Adame, Mark D., Wang, Zhuo., Boktor, Joseph C., Haney, Jillian., Wu, Wei-Li., Rabut, Claire., Ladinsky, Mark S., Hwang, Son-Jong., Guo, Yumei., Zhu, Qiyun., Griffiths, Jessica A., Knight , Rob., Bjorkman, Pamela J., Shapiro, Mikhail G., Geschwind, Daniel H., Holschneider, Daniel P., Fischbach, Michael A., Mazmanian, Sarkis K.
    雑誌名
    Nature
    602
    ページ
    647-653
    2022
    DOI
    10.1038/s41586-022-04396-8
    PMID
    35165440
    Online published
    2022 Feb 14
  • HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non-Small Cell Lung Cancer
    著者
    Yonesaka, Kimio., Tanizaki, Junko., Maenishi, Osamu., Haratani, Koji., Kawakami, Hisato., Tanaka, Kaoru., Hayashi, Hidetoshi., Sakai, Kazuko., Chiba, Yasutaka., Tsuya, Asuka., Goto, Hiroki., Otsuka, Eri., Okida, Hiroaki., Kobayashi, Maki., Yoshimoto, Ryoto., Funabashi, Masanori., Hashimoto, Yuuri., Hirotani, Kenji., Kagari, Takashi., Nishio, Kazuto., Nakagawa, Kazuhiko.
    雑誌名
    Clin Cancer Res .
    28
    ページ
    390-403
    2022
    DOI
    10.1158/1078-0432.CCR-21-3359
    PMID
    34921025
    Online published
    2021 Dec 17
  • Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains
    著者
    Hamasuna, Ryoichi., Hanzawa, Hiroyuki., Moritomo, Ayako., Matsumoto, Masahiro., Aono, Hisami., Tomisaki, Ikko., Akasaka, Takaaki., Fujimoto, Naohiro., SkovJensen, Jørgen.
    雑誌名
    J Infect Chemother
    28
    ページ
    377-383
    2022
    DOI
    10.1016/j.jiac.2021.11.011
    PMID
    34836778
    Online published
    2021 Nov 24
  • Highly sensitive in vitro cytokine release assay incorporating high-density preculture
    著者
    Ito, Shiho., Miwa, Kyoko., Hattori, Chiharu., Aida, Tetsuo., Tsuchiya, Yoshimi., Mori, Kazuhiko.
    雑誌名
    J Immunotoxicol
    18
    ページ
    136-143
    2021
    DOI
    10.1080/1547691X.2021.1984617
    PMID
    34644231
    Online published
    2021 Oct 13
  • Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
    著者
    Okajima, Daisuke.,Yasuda, Satoru., Maejima, Takanori., Karibe, Tsuyoshi., Sakurai, Ken., Aida, Tetsuo., Toki, Tadashi., Yamaguchi, Junko., Kitamura, Michiko., Kamei, Reiko., Fujitani, Tomomichi., Honda, Tomoyo., Shibutani, Tomoko., Muramatsu, Sumie., Nakada, Takashi., Goto, Riki., Takahashi, Shu., Yamaguchi, Miki., Hamada, Hirofumi., Noguchi, Yutaka., Murakami, Masato., Abe, Yuki., Agatsuma, Toshinori.
    雑誌名
    Mol Cancer Ther
    20
    ページ
    2329-2340
    2021
    DOI
    10.1158/1535-7163.MCT-21-0206
    PMID
    34413126
    Online published
    2021 Aug 19